Skip to main content

Heat Waves and Rising Temperatures: Human Health Impacts and the Determinants of Vulnerability

  • Chapter
  • First Online:
Climate Change and Global Public Health

Part of the book series: Respiratory Medicine ((RM))

Abstract

Globally, heat waves account for dramatic increases in mortality and morbidity; however, there is increasing awareness that day-to-day increases in temperature contribute to a significant risk of heat-related morbidity and mortality (HRMM) that over one or more warm seasons may exceed the public health burden of heat waves. Climate change has already and will continue to increase both average ambient temperatures and the frequency and intensity of excursions above those averages (i.e., heat waves or extreme heat events) and will thereby lead directly and indirectly to amplification of the risk of HRMM. This chapter provides a brief synopsis of our current knowledge about thermoregulation, thermotolerance, and the pathophysiology of heat stroke, and the multiple determinants of health and illness that influence the risk of HRMM and that collectively define vulnerability. A particular focus is on two vulnerable populations, older adults and children. An Environmental Health Multiple-Determinants Model of Vulnerability is presented as a conceptual framework to integrate that knowledge, with the intent of providing a tool that can facilitate compilation and translation of the information to interventions and adaptation strategies relevant at the individual level and/or subpopulation and population levels and at one or more geopolitical scales in developing and/or developed nations. Three overarching strategies for HRMM risk reduction are discussed, including Extreme Heat Event and Warm Season Heat Preparedness and Response Action Plans, Promote Good Health and Access to Quality Healthcare (reduces risk and increases resiliency), and Reduce/Manage Potential Exposure(s) (individual, community) to Ambient Heat and Other Physical Environmental Stressors. A key focus of this chapter is on integration and translation of knowledge.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Sawka MN, et al. Human adaptations to heat and cold stress. In: RTO HFM symposium on “Blowing hot and cold: protecting against climatic extremes”. Dresden, Germany: RTO-MP; 2001. p. KN4-1–15.

    Google Scholar 

  2. Hanna JM, Brown DE. Human heat tolerance: an anthropological perspective. Annu Rev Anthropol. 1983;12:259–84.

    Article  Google Scholar 

  3. Bouchama A, Knochel JP. Heat stroke. N Engl J Med. 2002;346(25):1978–88.

    Article  CAS  PubMed  Google Scholar 

  4. Wenger CB. Human adaptation to hot environments. In: Pandolf KB, Burr RE, editors. Medical aspects of harsh environments. Washington, DC: Office of The Surgeon General Department of the Army, United States of America; 2002. p. 51–86.

    Google Scholar 

  5. Meehl G, Tebaldi C. More intense, more frequent, and longer lasting heat waves in the 21st century. Science. 2004;305:994–7.

    Article  CAS  PubMed  Google Scholar 

  6. IPCC. Intergovernmental panel on climate change, climate change 2007: synthesis report. Contribution of Working Group I to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change. 2007. p. 103.

    Google Scholar 

  7. Robine JM, et al. Death toll exceeded 70,000 in Europe during the summer of 2003. C R Biol. 2008;331(2):171–8.

    Article  PubMed  Google Scholar 

  8. Fouillet A, et al. Excess mortality related to the august 2003 heat wave in France. Int Arch Occup Environ Health. 2006;80(1):16–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Luber G, McGeehin M. Climate change and extreme heat events. Am J Prev Med. 2008;35(5):429–35.

    Article  PubMed  Google Scholar 

  10. Gershunov A, Cayan D, Iacobellis S. The great 2006 California heat wave: signal of an increasing trend. J Clim. 2009;22:6181–203.

    Article  Google Scholar 

  11. Kozlowski DR, Edwards LM. An analysis and summary of the July 2006 record-breaking heat wave across the state of California. NOAA Western Regional Tech Attach, No. 07-05 (Feb 27, 2007). Salt Lake City: NOAA; 2007.

    Google Scholar 

  12. Hoshiko S, et al. A simple method for estimating excess mortality due to heat waves, as applied to the 2006 California heat wave. Int J Public Health. 2010;55(2):133–7.

    Article  PubMed  Google Scholar 

  13. Ostro BD, et al. Estimating the mortality effect of the July 2006 California heat wave. Environ Res. 2009;109(5):614–9.

    Article  CAS  PubMed  Google Scholar 

  14. Knowlton K, et al. The 2006 California heat wave: impacts on hospitalizations and emergency department visits. Environ Health Perspect. 2009;117(1):61–7.

    Article  PubMed  Google Scholar 

  15. Knowlton K, et al. Six climate change-related events in the United States accounted for about $14 billion in lost lives and health costs. Health Aff (Millwood). 2011;30(11):2167–76.

    Article  Google Scholar 

  16. Hajat S, et al. Impact of high temperatures on mortality: is there an added heat wave effect? Epidemiology. 2006;17(6):632–8.

    Article  PubMed  Google Scholar 

  17. Hajat S, Kosatky T. Heat-related mortality: a review and exploration of heterogeneity. J Epidemiol Community Health. 2010;64(9):753–60.

    Article  PubMed  Google Scholar 

  18. Ye X, et al. Ambient temperature and morbidity: a review of epidemiological evidence. Environ Health Perspect. 2012;120(1):19–28.

    Article  PubMed  Google Scholar 

  19. Zanobetti A, et al. Summer temperature variability and long-term survival among elderly people with chronic disease. Proc Natl Acad Sci U S A. 2012;109(17):6608–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. McMichael AJ, et al. International study of temperature, heat and urban mortality: the ‘ISOTHURM’ project. Int J Epidemiol. 2008;37(5):1121–31.

    Article  PubMed  Google Scholar 

  21. McMichael AJ, Woodruff RE, Hales S. Climate change and human health: present and future risks. Lancet. 2006;367(9513):859–69.

    Article  PubMed  Google Scholar 

  22. Chestnut LG, et al. Analysis of differences in hot-weather-related mortality across 44 US metropolitan areas. Environ Sci Technol. 1998;1:59–70.

    Google Scholar 

  23. Haines A, et al. Climate change and human health: impacts, vulnerability and public health. Public Health. 2006;120(7):585–96.

    Article  CAS  PubMed  Google Scholar 

  24. Haines A, Patz JA. Health effects of climate change. JAMA. 2004;291(1):99–103.

    Article  CAS  PubMed  Google Scholar 

  25. Kalkstein LS, Greene JS. An evaluation of climate/mortality relationships in large U.S. cities and the possible impacts of a climate change. Environ Health Perspect. 1997;105(1):84–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Ebi KL, et al. Weather changes associated with hospitalizations for cardiovascular diseases and stroke in California, 1983–1998. Int J Biometeorol. 2004;49(1):48–58.

    Article  CAS  PubMed  Google Scholar 

  27. Anderson BG, Bell ML. Weather-related mortality: how heat, cold, and heat waves affect mortality in the United States. Epidemiology. 2009;20(2):205–13.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Roberts EM, et al. Personal communication. 2012.

    Google Scholar 

  29. Durand-Lasserve A, Clerc V. Regularization and integration of irregular settlements: lessons from experience (working paper no. 6): Urban Management and Land; 1996.

    Google Scholar 

  30. Adachi M, et al. Oxidative stress impairs the heat stress response and delays unfolded protein recovery. PLoS One. 2009;4(11):e7719.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  31. Leon LR, Helwig BG. Heat stroke: role of the systemic inflammatory response. J Appl Physiol. 2010;109(6):1980–8.

    Article  CAS  PubMed  Google Scholar 

  32. Horowitz M, Robinson SD. Heat shock proteins and the heat shock response during hyper-thermia and its modulation by altered physiological conditions. Prog Brain Res. 2007;162:433–46.

    Article  CAS  PubMed  Google Scholar 

  33. Smith T, Zaitchik B, Gohlke J. Heat waves in the United States: definitions, patterns and trends. Clim Chang. 2013;118:811–25.

    Article  Google Scholar 

  34. Basu R. High ambient temperature and mortality: a review of epidemiologic studies from 2001 to 2008. Environ Health. 2009;8:40.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Trent RB, et al. Review of July 2006 heat wave related fatalities in California. Sacramento: California Department of Public Health; 2008. http://www.cdph.ca.gov/HealthInfo/injviosaf/Documents/HeatPlanAssessment-EPIC.pdf.

  36. Bouchama A, et al. Prognostic factors in heat wave related deaths: a meta-analysis. Arch Intern Med. 2007;167(20):2170–6.

    Article  PubMed  Google Scholar 

  37. CDC. Heat-related deaths—Los Angeles County, California, 1999–2000, and United States, 1979–1998. MMWR Morb Mortal Wkly Rep. 2001;50(29):623–6.

    Google Scholar 

  38. Medina-Ramon M, et al. Extreme temperatures and mortality: assessing effect modification by personal characteristics and specific cause of death in a multi-city case-only analysis. Environ Health Perspect. 2006;114(9):1331–6. http://dx.doi.org/. https://doi.org/10.1289/ehp.9074.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Naughton GA, Carlson JS. Reducing the risk of heat-related decrements to physical activity in young people. J Sci Med Sport. 2008;11(1):58–65.

    Article  CAS  PubMed  Google Scholar 

  40. Naughton MP, et al. Heat-related mortality during a 1999 heat wave in Chicago. Am J Prev Med. 2002;22(4):221–7.

    Article  PubMed  Google Scholar 

  41. Kovats RS, Hajat S. Heat stress and public health: a critical review. Annu Rev Public Health. 2008;29:41–55.

    Article  PubMed  Google Scholar 

  42. Belmin J, et al. Level of dependency: a simple marker associated with mortality during the 2003 heat wave among French dependent elderly people living in the community or in institutions. Age Ageing. 2007;36(3):298–303.

    Article  PubMed  Google Scholar 

  43. Stollberger C, Lutz W, Finsterer J. Heat-related side-effects of neurological and non-neurological medication may increase heat wave fatalities. Eur J Neurol. 2009;16(7):879–82.

    Article  CAS  PubMed  Google Scholar 

  44. Fouillet A, et al. Has the impact of heat waves on mortality changed in France since the European heat wave of summer 2003? A study of the 2006 heat wave. Int J Epidemiol. 2008;37(2):309–17.

    Article  CAS  PubMed  Google Scholar 

  45. Gehlert S, et al. Targeting health disparities: a model linking upstream determinants to downstream interventions: knowing about the interactions of societal factors and disease can enable targeted interventions to reduce health disparities. Health Aff (Millwood). 2008;27(2):339–49.

    Article  Google Scholar 

  46. Liburd LC, Sniezek JE. Changing times: new possibilities for community health and Well-being. Prev Chronic Dis. 2007. http://www.cdc.gov/pcd/issues/2007/jul/07_0048.htm. Accessed July 2007.

  47. Blum LN, Bresolin LB, Williams MA. From the AMA Council on scientific affairs heat-related illness during extreme weather emergencies. JAMA. 1998;279(19):1514.

    Article  CAS  PubMed  Google Scholar 

  48. Allen AJ, Segal-Gidan F. Heat-related illness in the elderly. Clin Geriatr. 2007;15(7):37–45.

    Google Scholar 

  49. Kenney WL, Munce TA. Invited review: aging and human temperature regulation. J Appl Physiol. 2003;95(6):2598–603.

    Article  PubMed  Google Scholar 

  50. Worfolk JB. Heat waves: their impact on the health of elders. Geriatr Nurs. 2000;21(2):70–7.

    Article  CAS  PubMed  Google Scholar 

  51. Jardine DS. Heat illness and heat stroke. Pediatr Rev. 2007;28(7):249–58.

    Article  PubMed  Google Scholar 

  52. Falk B, Dotan R. Children’s thermoregulation during exercise in the heat: a revisit. Appl Physiol Nutr Metab. 2008;33(2):420–7.

    Article  PubMed  Google Scholar 

  53. Bytomski JR, Squire DL. Heat illness in children. Curr Sports Med Rep. 2003;2(6):320–4.

    Article  PubMed  Google Scholar 

  54. Howe AS, Boden BP. Heat-related illness in athletes. Am J Sports Med. 2007;35(8):1384–95.

    Article  PubMed  Google Scholar 

  55. Bates G, Gazey C, Cena K. Factors affecting heat illness when working in conditions of thermal stress. J Hum Ergol (Tokyo). 1996;25(1):13–20.

    CAS  Google Scholar 

  56. Jay O, Kenny GP. Heat exposure in the Canadian workplace. Am J Ind Med. 2010;53(8):842–53.

    PubMed  Google Scholar 

  57. Rodahl K. Occupational health conditions in extreme environments. Ann Occup Hyg. 2003;47(3):241–52.

    CAS  PubMed  Google Scholar 

  58. Parsons KC. International standards for the assessment of the risk of thermal strain on clothed workers in hot environments. Ann Occup Hyg. 1999;43(5):297–308.

    Article  CAS  PubMed  Google Scholar 

  59. Cusack L, de Crespigny C, Athanasos P. Heat waves and their impact on people with alcohol, drug and mental health conditions: a discussion paper on clinical practice considerations. J Adv Nurs. 2011;67(4):915–22.

    Article  PubMed  Google Scholar 

  60. Kaciuba-Uscilko H, Grucza R. Gender differences in thermoregulation. Curr Opin Clin Nutr Metab Care. 2001;4(6):533–6.

    Article  CAS  PubMed  Google Scholar 

  61. Epstein Y, Moran DS. Thermal comfort and the heat stress indices. Ind Health. 2006;44(3):388–98.

    Article  PubMed  Google Scholar 

  62. McLellan TM. The importance of aerobic fitness in determining tolerance to uncompensable heat stress. Comp Biochem Physiol A Mol Integr Physiol. 2001;128(4):691–700.

    Article  CAS  PubMed  Google Scholar 

  63. Selkirk GA, McLellan TM. Influence of aerobic fitness and body fatness on tolerance to uncompensable heat stress. J Appl Physiol. 2001;91(5):2055–63.

    Article  CAS  PubMed  Google Scholar 

  64. Gagnon D, et al. Cold-water immersion and the treatment of hyperthermia: using 38.6 degrees C as a safe rectal temperature cooling limit. J Athl Train. 2010;45(5):439–44.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Hales JRS, Hubbard RW, Gaffin SL. Limitation of heat tolerance. In: Fregly MJ, Blatteis CM, editors. Handbook of physiology, environmental physiology, Suppl 14. New York: Wiley; 1996.

    Google Scholar 

  66. Weller AS, et al. Quantification of the decay and re-induction of heat acclimation in dry-heat following 12 and 26 days without exposure to heat stress. Eur J Appl Physiol. 2007;102(1):57–66.

    Article  PubMed  Google Scholar 

  67. Moseley PL. Heat shock proteins and heat adaptation of the whole organism. J Appl Physiol. 1997;83(5):1413–7.

    Article  CAS  PubMed  Google Scholar 

  68. Kuennen M, et al. Thermotolerance and heat acclimation may share a common mechanism in humans. Am J Physiol Regul Integr Comp Physiol. 2011;301(2):R524–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Moseley P. Stress proteins and the immune response. Immunopharmacology. 2000;48(3):299–302.

    Article  CAS  PubMed  Google Scholar 

  70. Fleming PJ, et al. Thermal balance and metabolic rate during upper respiratory tract infection in infants. Arch Dis Child. 1994;70(3):187–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. Dematte JE, et al. Near-fatal heat stroke during the 1995 heat wave in Chicago. Ann Intern Med. 1998;129(3):173–81.

    Article  CAS  PubMed  Google Scholar 

  72. Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature. 2000;408(6809):239–47.

    Article  CAS  PubMed  Google Scholar 

  73. Lee IT, Yang CM. Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases. Biochem Pharmacol. 2012;84(5):581–90.

    Article  CAS  PubMed  Google Scholar 

  74. Libby P. Inflammation in atherosclerosis. Nature. 2002;420(6917):868–74.

    Article  CAS  PubMed  Google Scholar 

  75. Agarwal SK, et al. Airflow obstruction, lung function, and risk of incident heart failure: the atherosclerosis risk in communities (ARIC) study. Eur J Heart Fail. 2012;14(4):414–22.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Park HS, Kim SR, Lee YC. Impact of oxidative stress on lung diseases. Respirology. 2009;14(1):27–38.

    Article  PubMed  Google Scholar 

  77. Emanuela F, et al. Inflammation as a link between obesity and metabolic syndrome. J Nutr Metab. 2012;2012:476380.

    Article  PubMed  PubMed Central  Google Scholar 

  78. Whitham M, Febbraio MA. HSP and diabetes. In: Asea AAA, Pederson BK, editors. Heat shock proteins and whole body physiology. New York: Springer; 2010. p. 3–18.

    Chapter  Google Scholar 

  79. Plummer LE, Smiley-Jewell S, Pinkerton KE. Impact of air pollution on lung inflammation and the roll of toll-like receptors. Int J Infereron Cytokine Mediator Res. 2012;4:43–57.

    CAS  Google Scholar 

  80. Breton CV, et al. Genetic variation in the glutathione synthesis pathway, air pollution, and children’s lung function growth. Am J Respir Crit Care Med. 2011;183(2):243–8.

    Article  PubMed  Google Scholar 

  81. Islam T, et al. Glutathione-S-transferase (GST) P1, GSTM1, exercise, ozone and asthma incidence in school children. Thorax. 2009;64(3):197–202.

    Article  CAS  PubMed  Google Scholar 

  82. Gilliland FD, et al. A theoretical basis for investigating ambient air pollution and children’s respiratory health. Environ Health Perspect. 1999;107(Suppl 3):403–7.

    Article  PubMed  PubMed Central  Google Scholar 

  83. Franchini M, et al. Air pollution, vascular disease and thrombosis: linking clinical data and pathogenic mechanisms. J Thromb Haemost. 2012;10(12):2438–51.

    Article  CAS  PubMed  Google Scholar 

  84. Miller MR, Shaw CA, Langrish JP. From particles to patients: oxidative stress and the cardiovascular effects of air pollution. Futur Cardiol. 2012;8(4):577–602.

    Article  CAS  Google Scholar 

  85. Basu R, Ostro BD. A multicounty analysis identifying the populations vulnerable to mortality associated with high ambient temperature in California. Am J Epidemiol. 2008;168(6):632–7.

    Article  PubMed  Google Scholar 

  86. Coris EE, Ramirez AM, Van Durme DJ. Heat illness in athletes: the dangerous combination of heat, humidity and exercise. Sports Med. 2004;34(1):9–16.

    Article  PubMed  Google Scholar 

  87. Fleming PJ, Azaz Y, Wigfield R. Development of thermoregulation in infancy: possible implications for SIDS. J Clin Pathol. 1992;45(11 Suppl):17–9.

    CAS  PubMed  Google Scholar 

  88. Falk B. Effects of thermal stress during rest and exercise in the paediatric population. Sports Med. 1998;25(4):221–40.

    Article  CAS  PubMed  Google Scholar 

  89. Bergeron MF, Devore C, Rice SG. Policy statement—climatic heat stress and exercising children and adolescents. Pediatrics. 2011;128(3):e741–7.

    Article  PubMed  Google Scholar 

  90. Prentice AM. The emerging epidemic of obesity in developing countries. Int J Epidemiol. 2006;35(1):93–9.

    Article  PubMed  Google Scholar 

  91. McConnell R, et al. Asthma in exercising children exposed to ozone: a cohort study. Lancet. 2002;359(9304):386–91.

    Article  CAS  PubMed  Google Scholar 

  92. Delfino RJ, et al. Association of asthma symptoms with peak particulate air pollution and effect modification by anti-inflammatory medication use. Environ Health Perspect. 2002;110(10):A607–17.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  93. Moreno-Macias H, et al. Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study. Respir Res. 2013;14(1):14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  94. Romieu I, et al. Genetic polymorphism of GSTM1 and antioxidant supplementation influ-ence lung function in relation to ozone exposure in asthmatic children in Mexico City. Thorax. 2004;59(1):8–10.

    CAS  PubMed  PubMed Central  Google Scholar 

  95. Lambert MI, Mann T, Dugas JP. Ethnicity and temperature regulation. Med Sport Sci. 2008;53:104–20.

    Article  PubMed  Google Scholar 

  96. Horowitz M. Heat acclimation and cross-tolerance against novel stressors: genomic-physiological linkage. Prog Brain Res. 2007;162:373–92.

    Article  CAS  PubMed  Google Scholar 

  97. Horowitz M, Kodesh E. Molecular signals that shape the integrative responses of the heat-acclimated phenotype. Med Sci Sports Exerc. 2010;42(12):2164–72.

    Article  CAS  PubMed  Google Scholar 

  98. Lau WKM, Kim K-M. The 2010 Pakistan flood and Russian heat wave: teleconnections of hydrometeorological extremes. J Hydrometeorol. 2012;13:392–403.

    Article  Google Scholar 

  99. Cayan D, et al. Climate scenarios for California. Sacramento: California Energy Commission, California Climate Change Center; 2006. p. 52.

    Google Scholar 

  100. CDPH. Heat-related illness and mortality: information for the public health network in California. In: public health impacts of climate change in California: community vulnerability assessments and adaptation strategies. Sacramento: California Department of Public Health, Public Health Institute; 2007. http://www.ehib.org/papers/Heat_Vulnerability_2007.pdf

    Google Scholar 

  101. Stone B, Hess JJ, Frumkin H. Urban form and extreme heat events: are sprawling cities more vulnerable to climate change than compact cities? Environ Health Perspect. 2010;118(10):1425–8.

    Article  PubMed  PubMed Central  Google Scholar 

  102. Oke T. The energetic basis of the urban heat island. Q J R Meteorol Soc. 1982;108(455):1–24.

    Google Scholar 

  103. United Nations. World urbanization prospects: the 2007 revision. New York: United Nations; 2008.

    Google Scholar 

  104. UNHabitat. Cities and climate change global report on human settlements 2011. United Nations Human Settlements Programme. London, UK/Washington, DC: Earthscan Ltd/Earthscan LLC; 2011.

    Google Scholar 

  105. WHO. World health statistics, vol. 2012. Geneva: World Health Organization; 2012.

    Google Scholar 

  106. CDC. Infectious disease and dermatologic conditions in evacuees and rescue workers after hurricane Katrina—multiple states, august–September, 2005. MMWR Morb Mortal Wkly Rep. 2005;54(38):961–4.

    Google Scholar 

  107. Keatinge WR. Death in heat waves. BMJ. 2003;327(7414):512–3.

    Article  PubMed  PubMed Central  Google Scholar 

  108. Semenza JC, et al. Excess hospital admissions during the July 1995 heat wave in Chicago. Am J Prev Med. 1999;16(4):269–77.

    Article  CAS  PubMed  Google Scholar 

  109. Dannenberg AL, Frumkin H, Jackson R. Making healthy places: designing and building for health, well-being, and sustainability. Washington, DC: Island Press; 2011.

    Book  Google Scholar 

  110. WHO. Heat-health action plans: guidance. Europe. Copenhagen: World Health Organization; 2008.

    Google Scholar 

  111. Durazo EM, et al. The health status and unique health challenges of rural older adults in California. Los Angeles: University of California, Los Angeles (UCLA) Center for Health Policy Research; 2011.

    Google Scholar 

  112. CHHSA, Strategic plan for an aging California population. Getting California ready for the “baby boomers”. Sacramento: California Health and Human Services Agency, Editor; 2003. p. 258.

    Google Scholar 

  113. Bernard SM, McGeehin MA. Municipal heat wave response plans. Am J Public Health. 2004;94(9):1520–2.

    Article  PubMed  PubMed Central  Google Scholar 

  114. Diaz J, Linares C, Tobias A. A critical comment on heat wave response plans. Eur J Pub Health. 2006;16(6):600.

    Article  Google Scholar 

  115. Richard L, Kosatsky T, Renouf A. Correlates of hot day air-conditioning use among middle-aged and older adults with chronic heart and lung diseases: the role of health beliefs and cues to action. Health Educ Res. 2011;26(1):77–88.

    Article  PubMed  Google Scholar 

  116. Aitsi-Selmi A, Murray V. Protecting the health and Well-being of populations from disasters: health and health Care in the Sendai Framework for disaster risk reduction 2015–2030. Prehosp Disaster Med. 2016;31(1):74–8.

    Article  PubMed  Google Scholar 

  117. Basu R, Gavin L, Pearson D, Ebisu K, Malig B. Examining the association between apparent temperature and mental health-related emergency room visits in California. Am J Epidemiol. 2018;187(4):726–35.

    Article  PubMed  Google Scholar 

  118. Benmarhnia T, Deguen S, Kaufman JS, Smargiassi A. Review article: vulnerability to heat-related mortality: a systematic review, meta-analysis, and meta-regression analysis. Epidemiology. 2015;26(6):781–93.

    Article  PubMed  Google Scholar 

  119. Bucci M, Marques SS, Oh D, Harris NB. Toxic stress in children and adolescents. Adv Pediatr Infect Dis. 2016;63(1):403–28.

    Google Scholar 

  120. Bunker A, Wildenhain J, Vandenbergh A, Henschke N, Rocklov J, Hajat S, Sauerborn R. Effects of air temperature on climate-sensitive mortality and morbidity outcomes in the elderly; a systematic review and meta-analysis of epidemiological evidence. EBioMedicine. 2016;6:258–68.

    Article  PubMed  PubMed Central  Google Scholar 

  121. Butler-Dawson J, Krisher L, Yoder H, Dally M, Sorensen C, Johnson RJ, Asensio C, Cruz A, Johnson EC, Carlton EJ, Tenney L, Asturias EJ, Newman LS. Evaluation of heat stress and cumulative incidence of acute kidney injury in sugarcane workers in Guatemala. Int Arch Occup Environ Health. 2019;

    Google Scholar 

  122. Cherry KE, Sampson L, Nezat PF, Cacamo A, Marks LD, Galea S. Long-term psychological outcomes in older adults after disaster: relationships to religiosity and social support. Aging Ment Health. 2015;19(5):430–43.

    Article  PubMed  Google Scholar 

  123. Chung EK, Siegel BS, Garg A, Conroy K, Gross RS, Long DA, Lewis G, Osman CJ, Jo Messito M, Wade R Jr, Shonna Yin H, Cox J, Fierman AH. Screening for social determinants of health among children and families living in poverty: a guide for clinicians. Curr Probl Pediatr Adolesc Health Care. 2016;46(5):135–53.

    Article  PubMed  PubMed Central  Google Scholar 

  124. Correa-Rotter R, Garcia-Trabanino R. Mesoamerican nephropathy. Semin Nephrol. 2019;39(3):263–71.

    Article  PubMed  Google Scholar 

  125. Dai W, Wang J, Kaminga AC, Chen L, Tan H, Lai Z, Deng J, Liu A. Predictors of recovery from post-traumatic stress disorder after the dongting lake flood in China: a 13–14 year follow-up study. BMC Psychiatry. 2016;16(1):382.

    Article  PubMed  PubMed Central  Google Scholar 

  126. Dodgen D, Donato D, Kelly N, La Greca A, Morganstein J, Reser J, Ruzek J, Schweitzer S, Shimamoto MM, Thigpen Tart K, Ursano R. Ch. 8: mental health and Well-being. The impacts of climate change on human health in the United States: a scientific assessment. Washington, DC: U. S. G. C. R. Program; 2016. p. 217–46.

    Google Scholar 

  127. Ely BR, Lovering AT, Horowitz M, Minson CT. Heat acclimation and cross tolerance to hypoxia: bridging the gap between cellular and systemic responses. Temperature (Austin). 2014;1(2):107–14.

    Article  Google Scholar 

  128. Gallo-Ruiz L, Sennett CM, Sanchez-Delgado M, Garcia-Urbina A, Gamez-Altamirano T, Basra K, Laws RL, Amador JJ, Lopez-Pilarte D, Tripodis Y, Brooks DR, McClean MD, Kupferman J, Friedman D, Aragon A, Gonzalez-Quiroz M, Scammell MK. Prevalence and risk factors for CKD among brickmaking Workers in La Paz Centro, Nicaragua. Am J Kidney Dis. 2019;

    Google Scholar 

  129. Gibbs L, Waters E, Bryant RA, Pattison P, Lusher D, Harms L, Richardson J, MacDougall C, Block K, Snowdon E, Gallagher HC, Sinnott V, Ireton G, Forbes D. Beyond bushfires: community, resilience and recovery - a longitudinal mixed method study of the medium to long term impacts of bushfires on mental health and social connectedness. BMC Public Health. 2013;13:1036.

    Article  PubMed  PubMed Central  Google Scholar 

  130. Gonzalez-Quiroz M, Pearce N, Caplin B, Nitsch D. What do epidemiological studies tell us about chronic kidney disease of undetermined cause in Meso-America? A systematic review and meta-analysis. Clin Kidney J. 2018;11(4):496–506.

    Article  PubMed  Google Scholar 

  131. Gronlund CJ. Racial and socioeconomic disparities in heat-related health effects and their mechanisms: a review. Curr Epidemiol Rep. 2014;1(3):165–73.

    Article  PubMed  PubMed Central  Google Scholar 

  132. Hornor G. Resilience. J Pediatr Health Care. 2017;31(3):384–90.

    Article  PubMed  Google Scholar 

  133. Horowitz M. Epigenetics and cytoprotection with heat acclimation. J Appl Physiol (1985). 2016;120(6):702–10.

    Article  CAS  Google Scholar 

  134. Horowitz M. Heat acclimation-mediated cross-tolerance: origins in within-life epigenetics? Front Physiol. 2017;8:548.

    Article  PubMed  PubMed Central  Google Scholar 

  135. James P, Hart JE, Banay RF, Laden F. Exposure to greenness and mortality in a Nationwide prospective cohort study of women. Environ Health Perspect. 2016;124(9):1344–52.

    Article  PubMed  PubMed Central  Google Scholar 

  136. Jayasumana C. Chronic interstitial nephritis in agricultural communities (CINAC) in Sri Lanka. Semin Nephrol. 2019;39(3):278–83.

    Article  PubMed  Google Scholar 

  137. Kenny GP, Wilson TE, Flouris AD, Fujii N. Heat exhaustion. Handb Clin Neurol. 2018;157:505–29.

    Article  PubMed  Google Scholar 

  138. King MA, Leon LR, Morse DA, Clanton TL. Unique cytokine and chemokine responses to exertional heat stroke in mice. J Appl Physiol. (1985). 2017;122(2):296–306.

    Article  CAS  PubMed  Google Scholar 

  139. King MA, Leon LR, Mustico DL, Haines JM, Clanton TL. Biomarkers of multiorgan injury in a preclinical model of exertional heat stroke. J Appl Physiol. (1985). 2015;118(10):1207–20.

    Article  CAS  PubMed  Google Scholar 

  140. Kravchenko J, Abernethy AP, Fawzy M, Lyerly HK. Minimization of heatwave morbidity and mortality. Am J Prev Med. 2013;44(3):274–82.

    Article  PubMed  Google Scholar 

  141. Kupferman J, Ramirez-Rubio O, Amador JJ, Lopez-Pilarte D, Wilker EH, Laws RL, Sennett C, Robles NV, Lau JL, Salinas AJ, Kaufman JS, Weiner DE, Scammell MK, McClean MD, Brooks DR, Friedman DJ. Acute kidney injury in sugarcane workers at risk for Mesoamerican nephropathy. Am J Kidney Dis. 2018;72(4):475–82.

    Article  PubMed  Google Scholar 

  142. Lane K, Wheeler K, Charles-Guzman K, Ahmed M, Blum M, Gregory K, Graber N, Clark N, Matte T. Extreme heat awareness and protective behaviors in New York City. J Urban Health. 2014;91(3):403–14.

    Article  PubMed  Google Scholar 

  143. Lee WS, Kim WS, Lim YH, Hong YC. High temperatures and kidney disease morbidity: a systematic review and meta-analysis. J Prev Med Public Health. 2019;52(1):1–13.

    Article  CAS  PubMed  Google Scholar 

  144. Leon LR. Common mechanisms for the adaptive responses to exercise and heat stress. J Appl Physiol (1985). 2016;120(6):662–3.

    Article  CAS  Google Scholar 

  145. Leon LR, Bouchama A. Heat stroke. Compr Physiol. 2015;5(2):611–47.

    Article  PubMed  Google Scholar 

  146. Levy BS, Sidel VW, Patz JA. Climate change and collective violence. Annu Rev Public Health. 2017;38:241–57.

    Article  PubMed  PubMed Central  Google Scholar 

  147. Madero M, Garcia-Arroyo FE, Sanchez-Lozada LG. Pathophysiologic insight into MesoAmerican nephropathy. Curr Opin Nephrol Hypertens. 2017;26(4):296–302.

    Article  CAS  PubMed  Google Scholar 

  148. O'Callaghan-Gordo C, Shivashankar R, Anand S, Ghosh S, Glaser J, Gupta R, Jakobsson K, Kondal D, Krishnan A, Mohan S, Mohan V, Nitsch D, Prabhakaran AP, Tandon N, Narayan KMV, Pearce N, Caplin B, Prabhakaran D. Prevalence of and risk factors for chronic kidney disease of unknown aetiology in India: secondary data analysis of three population-based cross-sectional studies. BMJ Open. 2019;9(3):e023353.

    Article  PubMed  PubMed Central  Google Scholar 

  149. Odame EA, Li Y, Zheng S, Vaidyanathan A, Silver K. Assessing heat-related mortality risks among rural populations: a systematic review and meta-analysis of epidemiological evidence. Int J Environ Res Public Health. 2018;15(8):1597–611.

    Google Scholar 

  150. Ordunez P, Nieto FJ, Martinez R, Soliz P, Giraldo GP, Mott SA, Hoy WE. Chronic kidney disease mortality trends in selected Central America countries, 1997-2013: clues to an epidemic of chronic interstitial nephritis of agricultural communities. J Epidemiol Community Health. 2018;72(4):280–6.

    Article  PubMed  Google Scholar 

  151. Pryor JL, Johnson EC, Roberts WO, Pryor RR. Application of evidence-based recommendations for heat acclimation: individual and team sport perspectives. Temperature (Austin). 2019;6(1):37–49.

    Article  Google Scholar 

  152. Schinasi LH, Hamra GB. A time series analysis of associations between daily temperature and crime events in Philadelphia, Pennsylvania. J Urban Health. 2017;94(6):892–900.

    Article  PubMed  PubMed Central  Google Scholar 

  153. Schmeltz MT, Gamble JL. Risk characterization of hospitalizations for mental illness and/or behavioral disorders with concurrent heat-related illness. PLoS One. 2017;12(10):e0186509.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  154. Schwartz RM, Gillezeau CN, Liu B, Lieberman-Cribbin W, Taioli E. Longitudinal impact of hurricane Sandy exposure on mental health symptoms. Int J Environ Res Public Health. 2017;14(9):957–68.

    Google Scholar 

  155. Thompson R, Hornigold R, Page L, Waite T. Associations between high ambient temperatures and heat waves with mental health outcomes: a systematic review. Public Health. 2018;161:171–91.

    Article  CAS  PubMed  Google Scholar 

  156. Thordardottir EB, Valdimarsdottir UA, Hansdottir I, Hauksdottir A, Dyregrov A, Shipherd JC, Elklit A, Resnick H, Gudmundsdottir B. Sixteen-year follow-up of childhood avalanche survivors. Eur J Psychotraumatol. 2016;7:30995.

    Article  PubMed  Google Scholar 

  157. Trombley J, Chalupka S, Anderko L. Climate change and mental health. Am J Nurs. 2017;117(4):44–52.

    Article  PubMed  Google Scholar 

  158. Vins H, Bell J, Saha S, Hess JJ. The mental health outcomes of drought: a systematic review and causal process diagram. Int J Environ Res Public Health. 2015;12(10):13251–75.

    Article  PubMed  PubMed Central  Google Scholar 

  159. Westaway K, Frank O, Husband A, McClure A, Shute R, Edwards S, Curtis J, Rowett D. Medicines can affect thermoregulation and accentuate the risk of dehydration and heat-related illness during hot weather. J Clin Pharm Ther. 2015;40(4):363–7.

    Article  CAS  PubMed  Google Scholar 

  160. Xu Z, Sheffield PE, Su H, Wang X, Bi Y, Tong S. The impact of heat waves on children's health: a systematic review. Int J Biometeorol. 2014;58(2):239–47.

    Article  PubMed  Google Scholar 

  161. Zahran S, Peek L, Snodgrass JG, Weiler S, Hempel L. Economics of disaster risk, social vulnerability, and mental health resilience. Risk Anal. 2011;31(7):1107–19.

    Article  PubMed  Google Scholar 

  162. Ziegler C, Morelli V, Fawibe O. Climate change and underserved communities. Prim Care. 2017;44(1):171–84.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Helene G. Margolis .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Margolis, H.G. (2021). Heat Waves and Rising Temperatures: Human Health Impacts and the Determinants of Vulnerability. In: Pinkerton, K.E., Rom, W.N. (eds) Climate Change and Global Public Health. Respiratory Medicine. Humana, Cham. https://doi.org/10.1007/978-3-030-54746-2_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-54746-2_7

  • Published:

  • Publisher Name: Humana, Cham

  • Print ISBN: 978-3-030-54745-5

  • Online ISBN: 978-3-030-54746-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics