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In Vivo Study of Laser Irradiation Techniques for the Treatment and Palliation of Lung Cancer Using Photodynamic Therapy

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Palliative Care for Chronic Cancer Patients in the Community

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Abstract

The increasing use of lasers in photodynamic therapy (PDT) for the treatment of cancer requires a better understanding of the effects of different laser parameters on the results of PDT. To minimize thermal damage and optimize healing benefits, we compared pulse, burst pulse, and continuous wave (CW) laser irradiation modes in PDT treatment of lung cancer in an in vivo animal model. Our results show that pulse and burst pulse modes, with high power density and short irradiation times relative to CW, improve the photodynamic reaction without thermal damage. In contrast, the CW irradiation mode induced thermal damage with the same radial profile as that of the laser beam and the temperature in the tissue.

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Acknowledgments

This research was supported by a grant from Academic Promotion Foundation of Chungnam National University of Korea (2015).

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Authors and Affiliations

  1. Department of Physics, Faculty of Arts and Science, Kocaeli University, Izmit-Kocaeli, Turkey

    Necla Kenar

  2. Department of Electric and Electronic Engineering, Faculty of Technology, Sakarya University of Applied Science, Serdivan-Sakarya, Turkey

    Hyun Soo Lim

  3. Department of Biomedical Engineering, School of Medicine, Chungnam National University, Daejeon, South Korea

    Hyun Soo Lim

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  1. Necla Kenar
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Correspondence to Hyun Soo Lim .

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  1. Middle East Cancer Consortium, Haifa, Israel

    Michael Silbermann

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Kenar, N., Lim, H.S. (2021). In Vivo Study of Laser Irradiation Techniques for the Treatment and Palliation of Lung Cancer Using Photodynamic Therapy. In: Silbermann, M. (eds) Palliative Care for Chronic Cancer Patients in the Community. Springer, Cham. https://doi.org/10.1007/978-3-030-54526-0_50

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  • DOI: https://doi.org/10.1007/978-3-030-54526-0_50

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