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Development of Biodegradable Polymeric Nanoparticles for Systemic Delivery

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Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 13))

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Abstract

In the previous chapter, the possible use of prodrug design in the enhancement of systemic delivery has been discussed. As the technique applicable to one drug may not be generalized to another drug, such an approach is comparatively labor intensive, and requires the structure of the agent designed to be manipulated case by case. As an alternative to, or as a complementary strategy for prodrug design, extensive efforts have been devoted to the development of diverse types of carriers over the last several decades. These carriers on one hand enable the delivery of multiple chemical entities and on the other hand allow for functionalization to enhance versatility and working performance. Due to their high structural flexibility, polymers have emerged as one of the most extensively studied materials for fabrication of such carriers. In this chapter, we will discuss different approaches to prepare polymeric particulates and will highlight the parameters to be characterized for optimal delivery performance in systemic delivery.

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  1. Department of Pharmaceutical Sciences, Butler University, Indianapolis, USA

    Nandita G. Das & Sudip K. Das

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  1. Nandita G. Das
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  1. School of Life and Health Sciences, The Chinese University of Hong Kong (Shenzhen), Shenzhen, China

    Wing-Fu Lai

Glossary

Atomization

A process of breaking bulk liquids into small droplets.

Biodegradable polymers

Polymers that degrade in the human and animal body and their degradation products are non-toxic.

Coacervation technique

A technique that involves the separation of a liquid phase of coating material from a polymeric solution and precipitation with the suspended core particles.

Dielectric constant

A measure of a substance’s ability to insulate charges from each other. Taken as a measure of solvent polarity, higher ε means higher polarity, and greater ability to stabilize charges.

Diffusion coefficient

A proportionality constant between the molar flux due to molecular diffusion and the gradient in the concentration of the species.

Glass transition temperature

The temperature at which certain polymers are rubbery (flexible or soft) but not in a completely molten state.

Hydrophilic polymeric matrix

A homogeneous aqueous soluble polymeric section.

Krebs cycle

The sequence of reactions by which most living cells generate energy during the process of aerobic respiration. It takes place in the mitochondria, consuming oxygen, producing carbon dioxide and water as waste products, and converting ADP to energy-rich ATP.

Supercritical fluid

A substance at a temperature and pressure above its critical point. It can behave like a gas, and dissolve materials like a liquid.

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Das, N.G., Das, S.K. (2020). Development of Biodegradable Polymeric Nanoparticles for Systemic Delivery. In: Lai, WF. (eds) Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications. Healthy Ageing and Longevity, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-030-54490-4_6

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