In Vivo Assessment of the Efficiency of Systemic Delivery

Ameena Shirin, V. K.; Sankar, Renu; Kotta, Sabna; Pramod, Kannissery

doi:10.1007/978-3-030-54490-4_4

V. K. Ameena Shirin³,
Renu Sankar³,
Sabna Kotta⁴ &
…
Kannissery Pramod³

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 13))

437 Accesses

Abstract

While the characterization of the physicochemical properties of a nanocarrier as presented in Chap. 3 is crucial to the evaluation and subsequent optimization of the carrier performance, as the ultimate goal of the development of a carrier is to enhance the efficiency of systemic delivery in a biological body, in vivo assessment of the carrier is unavoidable. In vivo assessment gives information about the mechanism of action, pharmacokinetics, and pharmacodynamics of the agent administered. Over the years, many animal models have been used for studying the in vivo performance of a drug, which in this case is either a free drug or a drug that has been pre-loaded into a carrier. Rodents like rats, mice, guinea pigs, and rabbits are the commonly used animals. Recently, zebrafish invertebrate models have also been established and used in in vivo studies. They are now used widely as a screening model to assess the in vivo performance of many drugs. Regarding the importance of in vivo assessment in the design and use of systemic delivery technologies in anti-aging medicine, in this chapter, we will describe the various in vivo techniques for the assessment of drug delivery.

V. K. Ameena Shirin and Renu Sankar: These authors have contributed equally to this chapter.

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Authors and Affiliations

College of Pharmaceutical Sciences, Government Medical College, Kozhikode, Kerala, 673008, India
V. K. Ameena Shirin, Renu Sankar & Kannissery Pramod
Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia
Sabna Kotta

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V. K. Ameena Shirin
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Renu Sankar
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Sabna Kotta
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Kannissery Pramod
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Correspondence to Kannissery Pramod .

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School of Life and Health Sciences, The Chinese University of Hong Kong (Shenzhen), Shenzhen, China
Wing-Fu Lai

Glossary

Bioavailability: It is the rate and extent of drug absorption to the circulatory system of the body from the site of administration.
Biocompatibility: It is the ability of a material being compatible with living tissues.
Bioluminescence: It is the production and emission of light by living organisms.
First-pass metabolism: It is a process that results in the reduction of drug concentration before reaching the systemic circulation when it is administered orally.
In vitro studies: Experiments performed outside of living organisms, such as in glass apparatus.
In vivo studies: Experiments for the determination of effects of the drug or other entities in a living organism like cells, tissues, or whole organisms, especially in animals and humans.
Pharmacodynamics: It is the study of the physiological and biochemical effects of a drug in the body after its administration.
Pharmacokinetics: It is the study of the time course of absorption, distribution, metabolism, and excretion of drugs.
Solubility: It is the maximum amount of solute dissolved per unit volume of a given solvent at equilibrium.
Systemic delivery: It is the administration of drugs to the body of the patient systemically through intravenous, oral, pulmonary, subcutaneous, etc.
Therapeutic efficacy: It is the capacity of a drug or other interventions to produce a therapeutic effect in the body.

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Ameena Shirin, V.K., Sankar, R., Kotta, S., Pramod, K. (2020). In Vivo Assessment of the Efficiency of Systemic Delivery. In: Lai, WF. (eds) Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications. Healthy Ageing and Longevity, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-030-54490-4_4

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DOI: https://doi.org/10.1007/978-3-030-54490-4_4
Published: 20 October 2020
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-54489-8
Online ISBN: 978-3-030-54490-4
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