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Surface Modification Strategies in Enhancing Systemic Delivery Performance

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Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 13))

Abstract

In Chap. 13, electrospinning has been introduced as a strategy to manipulate the physical properties of a therapeutics-loaded system and to enhance the versatility of drug delivery. In the remaining chapters in Section V, the use of chemical means to manipulate the surface properties of a carrier for more effective systemic drug delivery will be discussed. As a matter of fact, a therapeutic agent must stay in the body as long as it is needed to reach the intended site of action in order to elicit a therapeutic response. To extend the blood retention time of an agent, one commonly used strategy is surface modification. In this chapter, we will first discuss the principles of clearance of particulate drug delivery systems from the body by the mononuclear phagocyte system (MPS), followed by a discussion of the possible use of polymers as modifiers of the surface properties of the particulate systems for enhanced performance in systemic drug delivery. Finally, the applications of surface-modified particulates in non-MPS targeting, including cancer chemotherapy and delivery across the blood–brain barrier, will also be discussed.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Butler University, Indianapolis, IN, USA

    Sudip K. Das & Nandita G. Das

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  1. School of Life and Health Sciences, The Chinese University of Hong Kong (Shenzhen), Shenzhen, China

    Wing-Fu Lai

Glossary

Adsorption

Adhesion of molecules from a gas, liquid, or dissolved solid to a surface.

Amphiphilic polymers

Polymers possessing both hydrophilic and lipophilic properties.

Efflux pump

A proteinaceous transporter localized in the cytoplasmic membrane cells.

Graft polymer

A branched copolymer with one or more side chains of a homopolymer attached to the backbone of the main chain.

Liposomes

Spherical vesicles having at least one lipid bilayer. Liposomes can be used as a vehicle for administration of bioactive agents.

Macrophages

White blood cells that surround and kill microorganisms, remove dead cells, and stimulate the action of other immune system cells.

Major histocompatibility complex

Proteins that are essential for adaptive immunity.

Phagocytosis

The process by which a cell uses its plasma membrane to engulf a large particle, giving rise to an internal compartment called the phagosome.

Stem cell

A cell that has the ability to develop into many different cell types, from muscle cells to brain cells.

T cells

Lymphocyte immune cells that protect the body from pathogens and responsible for immunity against cancer cells.

van der Waals attractive forces

Weak non-covalent, non-ionic forces between atoms or molecules.

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Das, S.K., Das, N.G. (2020). Surface Modification Strategies in Enhancing Systemic Delivery Performance. In: Lai, WF. (eds) Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications. Healthy Ageing and Longevity, vol 13. Springer, Cham. https://doi.org/10.1007/978-3-030-54490-4_15

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