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Pathobiology of Precursors to Pancreatic Cancer

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Textbook of Pancreatic Cancer

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Abstract

The identification of noninvasive precursor lesions of pancreatic adenocarcinoma, in particular pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN) has led to the proposal of a multi-step progression model of pancreatic cancer. Early and late genetic alterations culminating in invasive cancer have been published. While the majority of pancreatic ductal adenocarcinoma are thought to arise from PanIN, important alternative pathways of carcinogenesis are available through IPMN. In this chapter features of pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), intraductal tubulopapillary neoplasm (ITPN), pancreatic intraductal oncocytic papillary neoplasm (IOPN) and mucinous cystic neoplasm (MCN) are discussed.

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Authors and Affiliations

  1. INNPATH, Institute of Pathology, University Clinic Innsbruck, Innsbruck, Austria

    Georg Oberhuber

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  1. Georg Oberhuber
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Correspondence to Georg Oberhuber .

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Editors and Affiliations

  1. Stavanger University Hospital, The University of Bergen, Bergen, Norway

    Kjetil Søreide

  2. Chirurgie (VTT), Innsbruck Medical University, Innsbruck, Tirol, Austria

    Stefan Stättner

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Oberhuber, G. (2021). Pathobiology of Precursors to Pancreatic Cancer. In: Søreide, K., Stättner, S. (eds) Textbook of Pancreatic Cancer. Springer, Cham. https://doi.org/10.1007/978-3-030-53786-9_15

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  • DOI: https://doi.org/10.1007/978-3-030-53786-9_15

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-53785-2

  • Online ISBN: 978-3-030-53786-9

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