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Vitamin D and Frailty

Abstract

Vitamin D is well known to have important and far-reaching effects across all aspects of physiology. It is particularly significant in the geriatric syndrome of frailty, as it has notable impacts on a number of systems that are critical to its development. This is also noteworthy when applied to the patient with kidney disease, as ongoing renal dysfunction reduces active vitamin D levels. Vitamin D deficiency has a range of clinical manifestations, including bone fragility, decreased muscle performance, and cognitive impairment. There is some preliminary evidence to suggest that daily supplementation of up to 1000 IU of vitamin D has beneficial outcomes as an adjunctive treatment for frailty.

Keywords

  • Vitamin D
  • Frailty
  • Muscle
  • Bone
  • Osteoporosis
  • Sarcopenia
  • Osteosarcopenia
  • Falls
  • Fracture
  • Kidney disease

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Feehan, J., Phu, S., Duque, G. (2021). Vitamin D and Frailty. In: Musso, C.G., Jauregui, J.R., Macías-Núñez, J.F., Covic, A. (eds) Frailty and Kidney Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-53529-2_8

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  • DOI: https://doi.org/10.1007/978-3-030-53529-2_8

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