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Trypanocidal and Herbicidal Activities of Endophytic Fungi Associated with Medicinal Plant Lafoensia pacari Living in Neotropical Wetland Pantanal of Brazil

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Neotropical Endophytic Fungi

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Abstract

Endophytes are microorganisms that inhabit plant tissues during at least one stage of their life cycle, and they do not cause any apparent symptom of disease on their hosts. Medicinal plants represent a particularly promising target for the studies of the endophytic fungal community as a source of bioactive molecules. In the present study, we evaluate the medicinal plant Lafoensia pacari present in the Neotropical wetland of Pantanal Matogrossense, Brazil, as a reservoir of endophytic fungi capable of producing bioactive metabolites. A total of 222 fungal endophyte crude extracts were evaluated for trypanocidal activity against a tropical parasite Trypanosoma cruzi and for herbicidal activity against seeds of Lactuca sativa and Allium schoenoprasum. Four extracts of Aspergillus aculeatus, Coniothyrium sp., and Valsariaceae sp. were active against T. cruzi and presented high efficiency while maintaining low cytotoxicity against host cells. The herbicidal activity was detected in 46 extracts, and 14 of them completely inhibited the germination of Lactuca sativa (lettuce) and Allium schoenoprasum (chive) seeds. Our results show that the medicinal Neotropical plant L. pacari is a rich reservoir of endophytic fungi producing bioactive metabolites that can be used for antiparasitic and agricultural purposes.

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Authors and Affiliations

  1. Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

    Soraya Sander Amorim, Camila Rodrigues de Carvalho, Jéssica Catarine Silva de Assis & Luiz Henrique Rosa

  2. Instituto René Rachou, FIOCRUZ-MG, Belo Horizonte, Brazil

    Camila Rodrigues de Carvalho, Tânia Maria de Almeida Alves & Policarpo Ademar Sales Junior

  3. Instituto René Rachou, FIOCRUZ-MG, Belo Horizonte, Minas Gearis, Brazil

    Carlos Leomar Zani

  4. Departamento de Botânica e Ecologia, Universidade Federal do Mato Grosso, Cuiabá, Brazil

    Marcos Antônio Soares

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  1. Soraya Sander Amorim
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  2. Camila Rodrigues de Carvalho
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  1. Departamento de Microbiologia, Instituto de Ciências Biológicas,Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Luiz Henrique Rosa

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Amorim, S.S. et al. (2021). Trypanocidal and Herbicidal Activities of Endophytic Fungi Associated with Medicinal Plant Lafoensia pacari Living in Neotropical Wetland Pantanal of Brazil. In: Rosa, L.H. (eds) Neotropical Endophytic Fungi. Springer, Cham. https://doi.org/10.1007/978-3-030-53506-3_3

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