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Immunotherapeutic Approach to the Treatment and Prevention of Obesity

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Abstract

Clinical availability of anti-obesity drugs is limited, and their inadequate effectiveness and safety concerns sometimes discourage widespread use. A therapeutic vaccine has the potential to be an attractive tool for preventing and treating obesity, because of the possibility of prolonged therapeutic effect and low frequency of administration. Experimental investigations have shown that vaccines targeting endogenous molecules that promote obesity could be a viable alternative. Recent novelties in drug-delivery systems and biotechnology will support further progress in vaccine development. This chapter provides an overview of recent advances in the area.

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References

  • Ambuhl PM, Tissot AC, Fulurija A, Maurer P, Nussberger J, Sabat R et al (2007) A vaccine for hypertension based on virus-like particles: preclinical efficacy and phase I safety and immunogenicity. J Hypertens 25(1):63–72

    Article  Google Scholar 

  • Andrade S, Pinho F, Ribeiro AM, Carreira M, Casanueva FF, Roy P et al (2013) Immunization against active ghrelin using virus-like particles for obesity treatment. Curr Pharm Des 19(36):6551–6558

    Article  CAS  Google Scholar 

  • Asakawa A, Inui A, Fujimiya M, Sakamaki R, Shinfuku N, Ueta Y et al (2005) Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin. Gut 54(1):18–24

    Article  CAS  Google Scholar 

  • Atkinson RL, Dhurandhar NV, Allison DB, Bowen RL, Israel BA, Albu JB et al (2005) Human adenovirus-36 is associated with increased body weight and paradoxical reduction of serum lipids. Int J Obes 29(3):281–286

    Article  CAS  Google Scholar 

  • Azegami T, Sasamura H, Hayashi K, Itoh H (2012) Vaccination against the angiotensin type 1 receptor for the prevention of L-NAME-induced nephropathy. Hypertens Res 35(5):492–499

    Article  CAS  Google Scholar 

  • Azegami T, Yuki Y, Sawada S, Mejima M, Ishige K, Akiyoshi K et al (2017) Nanogel-based nasal ghrelin vaccine prevents obesity. Mucosal Immunol 10(5):1351–1360

    Article  CAS  Google Scholar 

  • Azegami T, Yuki Y, Nakahashi R, Itoh H, Kiyono H (2018) Nanogel-based nasal vaccines for infectious and lifestyle-related diseases. Mol Immunol 98:19–24

    Article  CAS  Google Scholar 

  • Barnett BP, Hwang Y, Taylor MS, Kirchner H, Pfluger PT, Bernard V et al (2010) Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science 330(6011):1689–1692

    Article  CAS  Google Scholar 

  • Bourinbaiar AS, Jirathitikal V (2010) Effect of oral immunization with pooled antigens derived from adipose tissue on atherosclerosis and obesity indices. Vaccine 28(15):2763–2768

    Article  CAS  Google Scholar 

  • Bray GA, Fruhbeck G, Ryan DH, Wilding JP (2016) Management of obesity. Lancet 387(10031):1947–1956

    Article  Google Scholar 

  • Date Y, Shimbara T, Koda S, Toshinai K, Ida T, Murakami N et al (2006) Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus. Cell Metab 4(4):323–331

    Article  CAS  Google Scholar 

  • Dhurandhar NV, Whigham LD, Abbott DH, Schultz-Darken NJ, Israel BA, Bradley SM et al (2002) Human adenovirus Ad-36 promotes weight gain in male rhesus and marmoset monkeys. J Nutr 132(10):3155–3160

    Article  CAS  Google Scholar 

  • Flegal KM, Kit BK, Orpana H, Graubard BI (2013) Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA 309(1):71–82

    Article  CAS  Google Scholar 

  • Fulurija A, Lutz TA, Sladko K, Osto M, Wielinga PY, Bachmann MF et al (2008) Vaccination against GIP for the treatment of obesity. PLoS One 3(9):e3163

    Article  Google Scholar 

  • Haffer KN (2012) Effects of novel vaccines on weight loss in diet-induced-obese (DIO) mice. J Anim Sci Biotechnol 3(1):21

    Article  CAS  Google Scholar 

  • Hansel TT, Kropshofer H, Singer T, Mitchell JA, George AJ (2010) The safety and side effects of monoclonal antibodies. Nat Rev Drug Discov 9(4):325–338

    Article  CAS  Google Scholar 

  • Heymsfield SB, Wadden TA (2017) Mechanisms, pathophysiology, and management of obesity. N Engl J Med 376(3):254–266

    Article  CAS  Google Scholar 

  • Kim KR, Nam SY, Song YD, Lim SK, Lee HC, Huh KB (1999) Low-dose growth hormone treatment with diet restriction accelerates body fat loss, exerts anabolic effect and improves growth hormone secretory dysfunction in obese adults. Horm Res 51(2):78–84

    CAS  PubMed  Google Scholar 

  • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402(6762):656–660

    Article  CAS  Google Scholar 

  • Koriyama H, Nakagami H, Nakagami F, Osako MK, Kyutoku M, Shimamura M et al (2015) Long-term reduction of high blood pressure by angiotensin II DNA vaccine in spontaneously hypertensive rats. Hypertension 66(1):167–174

    Article  CAS  Google Scholar 

  • Kushnir N, Streatfield SJ, Yusibov V (2012) Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development. Vaccine 31(1):58–83

    Article  CAS  Google Scholar 

  • Lai QG, Jiang BQ, Zhou XH, Xu X, Gao ZN, Yuan KF (2010) The effects and mechanism of xenogeneic adipocyte vaccine for the prevention of obesity in rats. J Int Med Res 38(5):1700–1707

    Article  CAS  Google Scholar 

  • Lamichhane A, Azegami T, Kiyono H (2014) The mucosal immune system for vaccine development. Vaccine 32(49):6711–6723

    Article  CAS  Google Scholar 

  • Maletinska L, Matyskova R, Maixnerova J, Sykora D, Pychova M, Spolcova A et al (2011) The Peptidic GHS-R antagonist [D-Lys(3)]GHRP-6 markedly improves adiposity and related metabolic abnormalities in a mouse model of postmenopausal obesity. Mol Cell Endocrinol 343(1-2):55–62

    Article  CAS  Google Scholar 

  • Maurer P, Jennings GT, Willers J, Rohner F, Lindman Y, Roubicek K et al (2005) A therapeutic vaccine for nicotine dependence: preclinical efficacy, and Phase I safety and immunogenicity. Eur J Immunol 35(7):2031–2040

    Article  CAS  Google Scholar 

  • McClean PL, Irwin N, Cassidy RS, Holst JJ, Gault VA, Flatt PR (2007) GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet. Am J Physiol Endocrinol Metab 293(6):E1746–E1755

    Article  CAS  Google Scholar 

  • Miyawaki K, Yamada Y, Ban N, Ihara Y, Tsukiyama K, Zhou H et al (2002) Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat Med 8(7):738–742

    Article  CAS  Google Scholar 

  • Na HN, Nam JH (2014) Proof-of-concept for a virus-induced obesity vaccine; vaccination against the obesity agent adenovirus 36. Int J Obes 38(11):1470–1474

    Article  CAS  Google Scholar 

  • Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K et al (2001) A role for ghrelin in the central regulation of feeding. Nature 409(6817):194–198

    Article  CAS  Google Scholar 

  • Nochi T, Yuki Y, Takahashi H, Sawada S, Mejima M, Kohda T et al (2010) Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines. Nat Mater 9(7):572–578

    Article  CAS  Google Scholar 

  • Sadry SA, Drucker DJ (2013) Emerging combinatorial hormone therapies for the treatment of obesity and T2DM. Nat Rev Endocrinol 9(7):425–433

    Article  CAS  Google Scholar 

  • Tschop M, Smiley DL, Heiman ML (2000) Ghrelin induces adiposity in rodents. Nature 407(6806):908–913

    Article  CAS  Google Scholar 

  • Vizcarra JA, Kirby JD, Kim SK, Galyean ML (2007) Active immunization against ghrelin decreases weight gain and alters plasma concentrations of growth hormone in growing pigs. Domest Anim Endocrinol 33(2):176–189

    Article  CAS  Google Scholar 

  • Wang YC, McPherson K, Marsh T, Gortmaker SL, Brown M (2011) Health and economic burden of the projected obesity trends in the USA and the UK. Lancet 378(9793):815–825

    Article  Google Scholar 

  • WHO (2020). https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.

  • Wilson PW, D’Agostino RB, Sullivan L, Parise H, Kannel WB (2002) Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med 162(16):1867–1872

    Article  Google Scholar 

  • Wortley KE, Anderson KD, Garcia K, Murray JD, Malinova L, Liu R et al (2004) Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference. Proc Natl Acad Sci U S A 101(21):8227–8232

    Article  CAS  Google Scholar 

  • Wortley KE, del Rincon JP, Murray JD, Garcia K, Iida K, Thorner MO et al (2005) Absence of ghrelin protects against early-onset obesity. J Clin Invest 115(12):3573–3578

    Article  CAS  Google Scholar 

  • Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL (2008) Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132(3):387–396

    Article  CAS  Google Scholar 

  • Zigman JM, Nakano Y, Coppari R, Balthasar N, Marcus JN, Lee CE et al (2005) Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest 115(12):3564–3572

    Article  CAS  Google Scholar 

  • Zorrilla EP, Iwasaki S, Moss JA, Chang J, Otsuji J, Inoue K et al (2006) Vaccination against weight gain. Proc Natl Acad Sci U S A 103(35):13226–13231

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Keio University Health Center, Yokohama-shi, Japan

    Tatsuhiko Azegami

  2. Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

    Tatsuhiko Azegami & Hiroshi Itoh

Authors
  1. Tatsuhiko Azegami
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  2. Hiroshi Itoh
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Correspondence to Tatsuhiko Azegami .

Editor information

Editors and Affiliations

  1. Hospital das Clinicas, Sao Paulo University Medical School, Sao Paulo, Brazil

    Joel Faintuch

  2. Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Salomão Faintuch

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Azegami, T., Itoh, H. (2020). Immunotherapeutic Approach to the Treatment and Prevention of Obesity. In: Faintuch, J., Faintuch, S. (eds) Obesity and Diabetes. Springer, Cham. https://doi.org/10.1007/978-3-030-53370-0_22

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