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Sepsis

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Pediatric Critical Care

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Abstract

The management of a child with septic shock relies on a comprehensive understanding of the numerous disciplines embodied in the practice of pediatric critical care medicine. The child with septic shock may have simultaneous derangements in the function of virtually every system of the body including cardiovascular, respiratory, immune, renal, coagulation, hepatic, metabolic, and neurologic. The degree to which physiologic alterations are manifest in a given patient is variable and influenced by host and nonhost factors including the developmental stage, the presence of comorbidities, pathogen-related factors, and genetic influences on both the host inflammatory response and the response to pharmacologic agents, all combining to have a profound influence on outcome. The clinician must possess a systematic and multifaceted approach to these critically ill patients. The goal of this chapter is to provide a comprehensive description of the epidemiology, biology, and pathophysiology (at both the cellular and organ level) of sepsis, as well as outline the current principles of managing septic shock at both the individual and institutional level. It will be apparent that optimal management requires a strong working knowledge of cardiovascular physiology, infectious diseases, multiple organ interactions, immunity, coagulation, pharmacology, and the molecular biology of inflammation.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, University of Michigan, C.S. Mott Children’s Hospital, Ann Arbor, MI, USA

    Erin Carlton

  2. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    Angela Lorts

  3. Department of Pediatrics, Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital, Chicago, IL, USA

    Thomas P. Shanley

  4. Department of Pediatrics, Stanford University School of Medicine, Lucile Packard Children’s Hospital Stanford, Palo Alto, CA, USA

    Timothy T. Cornell

Authors
  1. Erin Carlton
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  2. Angela Lorts
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  3. Thomas P. Shanley
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  4. Timothy T. Cornell
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Corresponding author

Correspondence to Timothy T. Cornell .

Editor information

Editors and Affiliations

  1. Penn State Hershey Children’s Hospital, Pediatric Critical Care Medicine, Hershey, PA, USA

    Steven E. Lucking

  2. Division of Pediatric Critical Care, Department of Pediatrics, Janet Weis Children’s Hospital, Geisinger Medical Center, Danville, PA, USA

    Frank A. Maffei

  3. Department of Pediatrics/Divisions of Pediatric Critical and Palliative Care Medicine, Janet Weis Children’s Hospital at Geisinger, Geisinger Commonwealth School of Medicine, Danville, PA, USA

    Robert F. Tamburro

  4. Department of Pediatrics, Eastern Virginia Medical School, Children’s Hospital of The King’s Daughters, Norfolk, VA, USA

    Arno Zaritsky

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Carlton, E., Lorts, A., Shanley, T.P., Cornell, T.T. (2021). Sepsis. In: Lucking, S.E., Maffei, F.A., Tamburro, R.F., Zaritsky, A. (eds) Pediatric Critical Care . Springer, Cham. https://doi.org/10.1007/978-3-030-53363-2_34

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  • DOI: https://doi.org/10.1007/978-3-030-53363-2_34

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-53362-5

  • Online ISBN: 978-3-030-53363-2

  • eBook Packages: MedicineMedicine (R0)

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