Abstract
Since the introduction of positron emission tomography (PET) in the mid-1970s, multiple attempts were made to build a scanner able to cover a large portion of the body, but none led to a clinical research system. However, many research centers remained interested in the idea, and with the help of simulation studies, the potential of total-body PET was shown. The building of a system was started only 2 years ago, and the first clinical studies were performed at UC Davis in 2019. The reason for the success of total-body PET is the increased angle coverage of the subject. The larger this angle, the more coincidences are potentially detected by the system. Studies showed that a gain in sensitivity up to a factor 40 can be obtained with this new scanner design. This allows a reduction in administered dose as well as acquisition time, paving the way for dynamic PET imaging and long-term follow-up of patients. Although the main application of PET is in oncology, other disciplines like neurology, pediatrics, and pharmaceutical (drug) development can take advantage of the increased sensitivity.
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Thyssen, C., Vandenberghe, S. (2021). Total-Body PET. In: Dierckx, R.A., Otte, A., de Vries, E.F., van Waarde, A., Lammertsma, A.A. (eds) PET and SPECT of Neurobiological Systems. Springer, Cham. https://doi.org/10.1007/978-3-030-53176-8_3
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