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PET Imaging of Cyclooxygenases in Neuroinflammation

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PET and SPECT of Neurobiological Systems

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Abstract

Neuroinflammation has detrimental effects on brain functions and plays critical roles in the pathogenesis and progression of several neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, and dementia. Cyclooxygenase isoenzymes COX-1 and COX-2 are responsible for the conversion of arachidonic acid to prostanoids such as prostaglandins, thromboxanes, and prostacyclins. Aberrant expression and function of COX-1 and COX-2 isoforms in the brain are linked to various inflammatory conditions leading to neural death and manifestation of neurodegenerative disorders. Consequently, COX-1 and COX-2 have emerged as important biomarkers for functional imaging of neuroinflammation and associated neurodegenerative diseases with positron-emission tomography (PET). This chapter reviews recent advances of PET imaging agents for the noninvasive visualization and characterization of COX-1 and COX-2 enzymes in neuroinflammation.

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Authors and Affiliations

  1. Cross Cancer Institute, Department of Oncology, University of Alberta, Edmonton, AB, Canada

    Atul Bhardwaj & Frank Wuest

  2. Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada

    Atul Bhardwaj & Frank Wuest

  3. Department of Chemistry, University of Alberta, Edmonton, AB, Canada

    Frank Wuest

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  1. Atul Bhardwaj
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  2. Frank Wuest
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Correspondence to Frank Wuest .

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Editors and Affiliations

  1. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Rudi A.J.O. Dierckx

  2. Faculty of Electrical Engineering, Medical Engineering and Computer Science, Offenburg University, Offenburg, Germany

    Andreas Otte

  3. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Erik F.J. de Vries

  4. Nuclear Medicine and Molecular Imaging, University Medical Center, Groningen, The Netherlands

    Aren van Waarde

  5. Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers location VUmc, Amsterdam, The Netherlands

    Adriaan A. Lammertsma

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Bhardwaj, A., Wuest, F. (2021). PET Imaging of Cyclooxygenases in Neuroinflammation. In: Dierckx, R.A., Otte, A., de Vries, E.F., van Waarde, A., Lammertsma, A.A. (eds) PET and SPECT of Neurobiological Systems. Springer, Cham. https://doi.org/10.1007/978-3-030-53176-8_10

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