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Curcumin in the Management of Endometriosis

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Endometriosis in Adolescents

Abstract

Endometriosis is a chronic gynecological inflammatory disorder in which the immune system dysregulation is thought to play a role in its initiation and progression. Due to altered sex steroid receptor concentrations and other signaling defects, endometriotic tissues have an attenuated response to hormonal treatment. This hormonal resistance contributes to lesion survival, proliferation, and infertility. Current agency-approved hormonal therapies, including synthetic progestins, GnRH agonists, and danazol, are often of limited efficacy and counterproductive to fertility and cause systemic side effects due to suppression of endogenous steroid hormone levels. In this chapter, we highlighted the curcumin (diferuloylmethane, CUR), which has long been used as an anti-inflammatory folk medicine in Asian countries for this condition.

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Acknowledgments

This study was supported in part by National Institutes of Health Grants 1SC3 GM113751, U01 HD66439, 1R01HD057235, U54 CA118948, HD41749, S21MD000101, and G12-RR03034. This investigation was conducted in a facility constructed with support from Research Facilities Improvement Grant #C06 RR18386 from NIH/NCRR.

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Ohaegbulam, G., Chowdhury, I., Thompson, W.E. (2020). Curcumin in the Management of Endometriosis. In: Nezhat, C.H. (eds) Endometriosis in Adolescents. Springer, Cham. https://doi.org/10.1007/978-3-030-52984-0_40

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