Abstract
Polymer nanoparticles have gained significant attention as nanoplatform for drug delivery. Water-soluble smart polymers with special characteristics can be used therapeutically as nanocarrier in which the active ingredient is entrapped, encapsulated, adsorbed, or chemically attached. For preparation of nanocomposites for chemotherapy and photodynamic therapy, the thermosensitive star-like dextran-graft-poly-N-isopropylacrylamide and pH-sensitive copolymer dextran-graft-polyacrylamide in charged (anionic) form were used as a nanocontainer. The polymers were loaded by gold nanoparticles, photosensitizer chlorine e6, doxorubicin, and cisplatin. The nanosystems were characterized by quasi-elastic light scattering, UV–Vis spectrometry, electron microscopy and tested in vitro for their anticancer activity. The understanding of the processes occurring during the formation of multicomponent nanosystem is the urgent tasks for synthesis of efficient antitumor nanocomposites. It was found that an aggregation process becomes evident for multicomponent systems. It leads to decreasing of the chemotherapy and photodynamic activity of nanocomposite and can be disadvantages for their use in antitumor therapy.
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Acknowledgements
Authors are very grateful to academician V. F. Chekhun—the Director of R. E. Kavetsky Institute for Experimental Pathology, Oncology, and Radiobiology of the National Academy of Sciences of Ukraine, for fruitful collaboration.
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Kutsevol, N., Naumenko, A. (2020). Smart Nanocarriers for Delivery of Anticancer Drugs: Recent Advances and Disadvantages. In: Fesenko, O., Yatsenko, L. (eds) Nanooptics and Photonics, Nanochemistry and Nanobiotechnology, and Their Applications . Springer Proceedings in Physics, vol 247. Springer, Cham. https://doi.org/10.1007/978-3-030-52268-1_10
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DOI: https://doi.org/10.1007/978-3-030-52268-1_10
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