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Rosacea and Neurological Comorbidities

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Rosacea

Part of the book series: Updates in Clinical Dermatology ((UCD))

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Abstract

Rosacea is a chronic inflammatory skin disorder, which seems to have a neurovascular component. Flushing in rosacea has been reported to be associated with a neuropathic burning or stinging pain, and the release of a number of neuropeptides. Associated neuropeptides include vasoactive intestinal peptide, and pituitary adenylate cyclase activating peptide, which both promote neurogenic inflammation and have been related to neurological disorders, namely, migraine. An association between rosacea and several neurological conditions has been suggested, including Alzheimer’s disease, glioma, migraine, and Parkinson’s disease. This chapter critically discusses the presence of neurological comorbidities in rosacea, including possible pathophysiological mechanisms.

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Author information

Authors and Affiliations

  1. Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

    Nita Katarina Frifelt Wienholtz, Jacob Pontoppidan Thyssen & Alexander Egeberg

Authors
  1. Nita Katarina Frifelt Wienholtz
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  2. Jacob Pontoppidan Thyssen
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  3. Alexander Egeberg
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Editor information

Editors and Affiliations

  1. Louisiana State University, New Orleans, LA, USA

    John Havens Cary

  2. Dermatology Clinic, University of California San Francisco, San Francisco, CA, USA

    Howard I. Maibach

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Wienholtz, N.K.F., Thyssen, J.P., Egeberg, A. (2020). Rosacea and Neurological Comorbidities. In: Cary, J.H., Maibach, H.I. (eds) Rosacea. Updates in Clinical Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-030-52097-7_9

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  • DOI: https://doi.org/10.1007/978-3-030-52097-7_9

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-52096-0

  • Online ISBN: 978-3-030-52097-7

  • eBook Packages: MedicineMedicine (R0)

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