Abstract
As a consequence of industrialization, thousands of man-made chemicals have been developed with few undergoing rigorous safety assessment prior to commercial use. Ubiquitous exposure to these compounds, many of which act as endocrine-disrupting chemicals (EDCs), has been suggested to be one factor in the increasing incidence of numerous diseases, including endometriosis. Endometriosis, the presence of endometrial glands and stroma outside the uterus, is a common disorder of reproductive-age women. Although a number of population-based studies have suggested that exposure to environmental EDCs may affect a woman’s risk of developing this disease, results of epidemiology assessments are often equivocal. The development of endometriosis is, however, a process occurring over time; thus, a single assessment of toxicant body burden cannot definitively be linked to causation of disease. For this reason, numerous investigators have utilized a variety of rodent models to examine the impact of specific EDCs on the development of experimental endometriosis. These studies identified multiple chemicals capable of influencing physiologic processes necessary for the establishment and/or survival of ectopic tissues in rodents, suggesting that these compounds may also be of concern for women. Importantly, these models serve as useful tools to explore strategies that may prevent adverse outcomes following EDC exposure.
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References
Al Jishi T, Sergi C (2017) Current perspective of diethylstilbestrol (DES) exposure in mothers and offspring. Reprod Toxicol 71:71–77. https://doi.org/10.1016/j.reprotox.2017.04.009
Amaya SC, Savaris RF, Filipovic CJ, Wise JD, Hestermann E, Young SL et al (2014) Resveratrol and endometrium: a closer look at an active ingredient of red wine using in vivo and in vitro models. Reprod Sci 21(11):1362–1369. https://doi.org/10.1177/1933719114525271
Androutsopoulos VP, Tsatsakis AM, Spandidos DA (2009) Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention. BMC Cancer 9:187. https://doi.org/10.1186/1471-2407-9-187
Baranov V, Malysheva O, Yarmolinskaya M (2018) Pathogenomics of endometriosis development. Int J Mol Sci 19(7). https://doi.org/10.3390/ijms19071852
Barker DJ (2004) The developmental origins of adult disease. J Am Coll Nutr 23(6 Suppl):588S–595S
Birnbaum LS, Tuomisto J (2000) Non-carcinogenic effects of TCDD in animals. Food Addit Contam 17(4):275–288. https://doi.org/10.1080/026520300283351
Bock KW, Kohle C (2006) Ah receptor: dioxin-mediated toxic responses as hints to deregulated physiologic functions. Biochem Pharmacol 72(4):393–404. https://doi.org/10.1016/j.bcp.2006.01.017
Bois FY, Eskenazi B (1994) Possible risk of endometriosis for Seveso, Italy, residents: an assessment of exposure to dioxin. Environ Health Perspect 102(5):476–477. https://doi.org/10.1289/ehp.94102476
Brosens JJSM, Teklenburg G, Nautiyal J, Salter S, Lucas ES, Steel JH, Christian M, Chan YW, Boomsma CM, Moore JD, Hartshorne GM, Sucurovic S, Mulac-Jericevic B, Heijnen CJ, Quenby S, Koerkamp MJ, Holstege FC, Shmygol A, Macklon NS (2014, Feb 6) Uterine selection of human embryos at implantation. Sci Rep 4:3894
Bruner-Tran KL, Osteen KG (2010) Dioxin-like PCBs and endometriosis. Syst Biol Reprod Med 56(2):132–146. https://doi.org/10.3109/19396360903381023
Bruner-Tran KL, Osteen KG (2011) Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations. Reprod Toxicol 31(3):344–350. https://doi.org/10.1016/j.reprotox.2010.10.003
Bruner-Tran KL, Rier SE, Eisenberg E, Osteen KG (1999) The potential role of environmental toxins in the pathophysiology of endometriosis. Gynecol Obstet Investig 48(Suppl 1):45–56. https://doi.org/10.1159/000052868
Bruner-Tran KL, Eisenberg E, Yeaman GR, Anderson TA, McBean J, Osteen KG (2002) Steroid and cytokine regulation of matrix metalloproteinase expression in endometriosis and the establishment of experimental endometriosis in nude mice. J Clin Endocrinol Metab 87(10):4782–4791. https://doi.org/10.1210/jc.2002-020418
Bruner-Tran KL, Yeaman GR, Crispens MA, Igarashi TM, Osteen KG (2008) Dioxin may promote inflammation-related development of endometriosis. Fertil Steril 89(5 Suppl):1287–1298. https://doi.org/10.1016/j.fertnstert.2008.02.102
Bruner-Tran KL, Ding T, Osteen KG (2010) Dioxin and endometrial progesterone resistance. Semin Reprod Med 28(1):59–68. https://doi.org/10.1055/s-0029-1242995
Bruner-Tran KL, Osteen KG, Taylor HS, Sokalska A, Haines K, Duleba AJ (2011) Resveratrol inhibits development of experimental endometriosis in vivo and reduces endometrial stromal cell invasiveness in vitro. Biol Reprod 84(1):106–112. https://doi.org/10.1095/biolreprod.110.086744
Bruner-Tran KL, Herington JL, Duleba AJ, Taylor HS, Osteen KG (2013) Medical management of endometriosis: emerging evidence linking inflammation to disease pathophysiology. Minerva Ginecol 65(2):199–213
Bruner-Tran KL, Duleba AJ, Taylor HS, Osteen KG (2016) Developmental toxicant exposure is associated with Transgenerational Adenomyosis in a murine model. Biol Reprod 95(4):73. https://doi.org/10.1095/biolreprod.116.138370
Bruner-Tran KL, Mokshagundam S, Herington JL, Ding T, Osteen KG (2018) Rodent models of experimental endometriosis: identifying mechanisms of disease and therapeutic targets. Curr Womens Health Rev 14(2):173–188. https://doi.org/10.2174/1573404813666170921162041
Bruner-Tran KL, Mokshagundam S, Barlow A, Ding T, Osteen KG (2019) Paternal environmental toxicant exposure and risk of adverse pregnancy outcomes. Curr Obstet Gynecol Rep 8:103–113
Buck Louis GM, Peterson CM, Chen Z, Croughan M, Sundaram R, Stanford J et al (2013) Bisphenol A and phthalates and endometriosis: the endometriosis: natural history, diagnosis and outcomes study. Fertil Steril 100(1):162–169. e1-2. https://doi.org/10.1016/j.fertnstert.2013.03.026
Bulun SE, Zeitoun KM, Kilic G (2000) Expression of dioxin-related transactivating factors and target genes in human eutopic endometrial and endometriotic tissues. Am J Obstet Gynecol 182(4):767–775. https://doi.org/10.1016/s0002-9378(00)70325-5
Bulun SE, Yilmaz BD, Sison C, Miyazaki K, Bernardi L, Liu S et al (2019) Endometriosis. Endocr Rev 40(4):1048–1079. https://doi.org/10.1210/er.2018-00242
Burbach KM, Poland A, Bradfield CA (1992) Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc Natl Acad Sci U S A 89(17):8185–8189. https://doi.org/10.1073/pnas.89.17.8185
Burney RO, Giudice LC (2012) Pathogenesis and pathophysiology of endometriosis. Fertil Steril 98(3):511–519. https://doi.org/10.1016/j.fertnstert.2012.06.029
Chiappini F, Sanchez M, Miret N, Cocca C, Zotta E, Ceballos L et al (2019) Exposure to environmental concentrations of hexachlorobenzene induces alterations associated with endometriosis progression in a rat model. Food Chem Toxicol 123:151–161. https://doi.org/10.1016/j.fct.2018.10.056
Codagnone MG, Spichak S, O’Mahony SM, O’Leary OF, Clarke G, Stanton C et al (2019) Programming bugs: microbiota and the developmental origins of brain health and disease. Biol Psychiatry 85(2):150–163. https://doi.org/10.1016/j.biopsych.2018.06.014
Cummings AM, Metcalf JL, Birnbaum L (1996) Promotion of endometriosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats and mice: time-dose dependence and species comparison. Toxicol Appl Pharmacol 138(1):131–139. https://doi.org/10.1006/taap.1996.0106
Cummings AM, Hedge JM, Birnbaum LS (1999) Effect of prenatal exposure to TCDD on the promotion of endometriotic lesion growth by TCDD in adult female rats and mice. Toxicol Sci 52(1):45–49. https://doi.org/10.1093/toxsci/52.1.45
Darbre PD (2017) Endocrine disruptors and obesity. Curr Obes Rep 6(1):18–27. https://doi.org/10.1007/s13679-017-0240-4
De Coster S, van Larebeke N (2012) Endocrine-disrupting chemicals: associated disorders and mechanisms of action. J Environ Public Health 2012:713696. https://doi.org/10.1155/2012/713696
Denison MS, Faber SC (2017) And now for something completely different: diversity in ligand-dependent activation of ah receptor responses. Curr Opin Toxicol 2:124–131. https://doi.org/10.1016/j.cotox.2017.01.006
Ding T, McConaha M, Boyd KL, Osteen KG, Bruner-Tran KL (2011) Developmental dioxin exposure of either parent is associated with an increased risk of preterm birth in adult mice. Reprod Toxicol 31(3):351–358. https://doi.org/10.1016/j.reprotox.2010.11.003
Dull AM, Moga MA, Dimienescu OG, Sechel G, Burtea V, Anastasiu CV (2019) Therapeutic approaches of resveratrol on endometriosis via anti-inflammatory and anti-Angiogenic pathways. Molecules 24(4). https://doi.org/10.3390/molecules24040667
Eskenazi B, Mocarelli P, Warner M, Samuels S, Vercellini P, Olive D et al (2002) Serum dioxin concentrations and endometriosis: a cohort study in Seveso, Italy. Environ Health Perspect 110(7):629–634. https://doi.org/10.1289/ehp.02110629
FDA US. Phthalates. December 5, 2013. https://www.fda.gov/cosmetics/cosmetic-ingredients/phthalates. Accessed July 24 2019
Fujii-Kuriyama Y, Kawajiri K (2010) Molecular mechanisms of the physiological functions of the aryl hydrocarbon (dioxin) receptor, a multifunctional regulator that senses and responds to environmental stimuli. Proc Jpn Acad Ser B Phys Biol Sci 86(1):40–53. https://doi.org/10.2183/pjab.86.40
Gasiewicz TA, Henry EC, Collins LL (2008) Expression and activity of aryl hydrocarbon receptors in development and cancer. Crit Rev Eukaryot Gene Expr 18(4):279–321
Giuseppe Benagiano IB, LIppi D (2015) Endometriosis: ancient or modern disease? Indian J Med Res 141(2):236–238
Guo SW (2007) Nuclear factor-kappab (NF-kappaB): an unsuspected major culprit in the pathogenesis of endometriosis that is still at large? Gynecol Obstet Investig 63(2):71–97. https://doi.org/10.1159/000096047
Harris RM, Waring RH (2012) Diethylstilboestrol–a long-term legacy. Maturitas 72(2):108–112. https://doi.org/10.1016/j.maturitas.2012.03.002
Heilier JF, Nackers F, Verougstraete V, Tonglet R, Lison D, Donnez J (2005) Increased dioxin-like compounds in the serum of women with peritoneal endometriosis and deep endometriotic (adenomyotic) nodules. Fertil Steril 84(2):305–312. https://doi.org/10.1016/j.fertnstert.2005.04.001
Heindel JJ (2006) Role of exposure to environmental chemicals in the developmental basis of reproductive disease and dysfunction. Semin Reprod Med 24(3):168–177. https://doi.org/10.1055/s-2006-944423
Hernandez-Ochoa I, Karman BN, Flaws JA (2009) The role of the aryl hydrocarbon receptor in the female reproductive system. Biochem Pharmacol 77(4):547–559. https://doi.org/10.1016/j.bcp.2008.09.037
Hsu CN, Tain YL (2019) The good, the bad, and the ugly of pregnancy nutrients and developmental programming of adult disease. Nutrients 11(4). https://doi.org/10.3390/nu11040894
Huang Q, Chen Y, Chen Q, Zhang H, Lin Y, Zhu M et al (2017) Dioxin-like rather than non-dioxin-like PCBs promote the development of endometriosis through stimulation of endocrine-inflammation interactions. Arch Toxicol 91(4):1915–1924. https://doi.org/10.1007/s00204-016-1854-0
Humphrey-Johnson A, Abukalam R, Eltom SE (2015) Stability of the aryl hydrocarbon receptor and its regulated genes in the low activity variant of Hepa-1 cell line. Toxicol Lett 233(2):59–67. https://doi.org/10.1016/j.toxlet.2015.01.016
Igarashi TM, Bruner-Tran KL, Yeaman GR, Lessey BA, Edwards DP, Eisenberg E et al (2005) Reduced expression of progesterone receptor-B in the endometrium of women with endometriosis and in cocultures of endometrial cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fertil Steril 84(1):67–74. https://doi.org/10.1016/j.fertnstert.2005.01.113
Inadera H (2015) Neurological effects of Bisphenol A and its analogues. Int J Med Sci 12(12):926–936. https://doi.org/10.7150/ijms.13267
Jeseta M, Crha T, Zakova J, Ventruba P (2019) Bisphenols in the pathology of reproduction. Ceska Gynekol 84(2):161–165
Jiang YZ, Wang K, Fang R, Zheng J (2010) Expression of aryl hydrocarbon receptor in human placentas and fetal tissues. J Histochem Cytochem 58(8):679–685. https://doi.org/10.1369/jhc.2010.955955
Johnson KL, Cummings AM, Birnbaum LS (1997) Promotion of endometriosis in mice by polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls. Environ Health Perspect 105(7):750–755. https://doi.org/10.1289/ehp.97105750
Jones RL, Lang SA, Kendziorski JA, Greene AD, Burns KA (2018) Use of a mouse model of experimentally induced endometriosis to evaluate and compare the effects of Bisphenol A and Bisphenol AF exposure. Environ Health Perspect 126(12):127004. https://doi.org/10.1289/EHP3802
Larigot L, Juricek L, Dairou J, Coumoul X (2018) AhR signaling pathways and regulatory functions. Biochim Open 7:1–9. https://doi.org/10.1016/j.biopen.2018.05.001
Levine H, Jorgensen N, Martino-Andrade A, Mendiola J, Weksler-Derri D, Mindlis I et al (2017) Temporal trends in sperm count: a systematic review and meta-regression analysis. Hum Reprod Update 23(6):646–659. https://doi.org/10.1093/humupd/dmx022
Maia H Jr, Haddad C, Coelho G, Casoy J (2012) Role of inflammation and aromatase expression in the eutopic endometrium and its relationship with the development of endometriosis. Womens Health (Lond) 8(6):647–658. https://doi.org/10.2217/whe.12.52
Mandy M, Nyirenda M (2018) Developmental origins of health and disease: the relevance to developing nations. Int Health 10(2):66–70. https://doi.org/10.1093/inthealth/ihy006
Matsunawa M, Amano Y, Endo K, Uno S, Sakaki T, Yamada S et al (2009) The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages. Toxicol Sci 109(1):50–58. https://doi.org/10.1093/toxsci/kfp044
Meeker JD (2012) Exposure to environmental endocrine disruptors and child development. Arch Pediatr Adolesc Med 166(6):E1–E7. https://doi.org/10.1001/archpediatrics.2012.241
Mimura J, Fujii-Kuriyama Y (2003) Functional role of AhR in the expression of toxic effects by TCDD. Biochim Biophys Acta 1619(3):263–268. https://doi.org/10.1016/s0304-4165(02)00485-3
Minguez-Alarcon L, Hauser R, Gaskins AJ (2016) Effects of bisphenol A on male and couple reproductive health: a review. Fertil Steril 106(4):864–870. https://doi.org/10.1016/j.fertnstert.2016.07.1118
Mokarizadeh A, Faryabi MR, Rezvanfar MA, Abdollahi M (2015) A comprehensive review of pesticides and the immune dysregulation: mechanisms, evidence and consequences. Toxicol Mech Methods 25(4):258–278. https://doi.org/10.3109/15376516.2015.1020182
Nayyar T, Bruner-Tran KL, Piestrzeniewicz-Ulanska D, Osteen KG (2007) Developmental exposure of mice to TCDD elicits a similar uterine phenotype in adult animals as observed in women with endometriosis. Reprod Toxicol 23(3):326–336. https://doi.org/10.1016/j.reprotox.2006.09.007
Nazir S, Usman Z, Imran M, Lone KP, Ahmad G (2018) Women diagnosed with endometriosis show high serum levels of diethyl hexyl phthalate. J Hum Reprod Sci 11(2):131–136. https://doi.org/10.4103/jhrs.JHRS_137_17
Nilsson EE, Sadler-Riggleman I, Skinner MK (2018) Environmentally induced epigenetic transgenerational inheritance of disease. Environ Epigenet 4(2):dvy016. https://doi.org/10.1093/eep/dvy016
Noakes R (2015) The aryl hydrocarbon receptor: a review of its role in the physiology and pathology of the integument and its relationship to the tryptophan metabolism. Int J Tryptophan Res 8:7–18. https://doi.org/10.4137/IJTR.S19985
Patel BG, Rudnicki M, Yu J, Shu Y, Taylor RN (2017) Progesterone resistance in endometriosis: origins, consequences and interventions. Acta Obstet Gynecol Scand 96(6):623–632. https://doi.org/10.1111/aogs.13156
Patel BG, Lenk EE, Lebovic DI, Shu Y, Yu J, Taylor RN (2018) Pathogenesis of endometriosis: interaction between endocrine and inflammatory pathways. Best Pract Res Clin Obstet Gynaecol 50:50–60. https://doi.org/10.1016/j.bpobgyn.2018.01.006
Peters JM, Narotsky MG, Elizondo G, Fernandez-Salguero PM, Gonzalez FJ, Abbott BD (1999) Amelioration of TCDD-induced teratogenesis in aryl hydrocarbon receptor (AhR)-null mice. Toxicol Sci 47(1):86–92. https://doi.org/10.1093/toxsci/47.1.86
Post CM, Boule LA, Burke CG, O’Dell CT, Winans B, Lawrence BP (2019) The ancestral environment shapes antiviral CD8(+) T cell responses across generations. iScience 20:168–183. https://doi.org/10.1016/j.isci.2019.09.014
Quitmeyer A, Roberts R (2007) Babies, bottles, and bisphenol A: the story of a scientist-mother. PLoS Biol 5(7):e200. https://doi.org/10.1371/journal.pbio.0050200
Rashidi BH, Amanlou M, Lak TB, Ghazizadeh M, Eslami B (2017) A case-control study of bisphenol A and endometrioma among subgroup of Iranian women. J Res Med Sci 22:7. https://doi.org/10.4103/1735-1995.199086
Resuehr D, Glore DR, Taylor HS, Bruner-Tran KL, Osteen KG (2012) Progesterone-dependent regulation of endometrial cannabinoid receptor type 1 (CB1-R) expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Fertil Steril 98(4):948–56 e1. https://doi.org/10.1016/j.fertnstert.2012.06.009
Revel A, Raanani H, Younglai E, Xu J, Rogers I, Han R et al (2003) Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene. J Appl Toxicol 23(4):255–261. https://doi.org/10.1002/jat.916
Rier SE, Martin DC, Bowman RE, Dmowski WP, Becker JL (1993) Endometriosis in rhesus monkeys (Macaca mulatta) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundam Appl Toxicol 21(4):433–441
Rogers JA, Metz L, Yong VW (2013) Review: endocrine disrupting chemicals and immune responses: a focus on bisphenol-A and its potential mechanisms. Mol Immunol 53(4):421–430. https://doi.org/10.1016/j.molimm.2012.09.013
Roseboom TJ, van der Meulen JH, Ravelli AC, Osmond C, Barker DJ, Bleker OP (2001) Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview. Mol Cell Endocrinol 185(1–2):93–98
Sampson JA (1927) Metastatic or embolic endometriosis, due to the menstrual dissemination of endometrial tissue into the venous circulation. Am J Pathol 3(2):93–110. 43
Schug TT, Janesick A, Blumberg B, Heindel JJ (2011) Endocrine disrupting chemicals and disease susceptibility. J Steroid Biochem Mol Biol 127(3–5):204–215. https://doi.org/10.1016/j.jsbmb.2011.08.007
Signorile PG, Spugnini EP, Mita L, Mellone P, D’Avino A, Bianco M et al (2010) Pre-natal exposure of mice to bisphenol A elicits an endometriosis-like phenotype in female offspring. Gen Comp Endocrinol 168(3):318–325. https://doi.org/10.1016/j.ygcen.2010.03.030
Skinner MK (2014) Endocrine disruptor induction of epigenetic transgenerational inheritance of disease. Mol Cell Endocrinol 398(1–2):4–12. https://doi.org/10.1016/j.mce.2014.07.019
Smarr MM, Kannan K, Buck Louis GM (2016) Endocrine disrupting chemicals and endometriosis. Fertil Steril 106(4):959–966. https://doi.org/10.1016/j.fertnstert.2016.06.034
Stockinger B, Di Meglio P, Gialitakis M, Duarte JH (2014) The aryl hydrocarbon receptor: multitasking in the immune system. Annu Rev Immunol 32:403–432. https://doi.org/10.1146/annurev-immunol-032713-120245
Straub RH (2014) Interaction of the endocrine system with inflammation: a function of energy and volume regulation. Arthritis Res Ther 16(1):203. https://doi.org/10.1186/ar4484
Susheelamma CJ, Pillai SM, Asha Nair S (2018) Oestrogen, progesterone and stem cells: the discordant trio in endometriosis? Expert Rev Mol Med 20:e2. https://doi.org/10.1017/erm.2017.13
Tibbetts TA, Conneely OM, O’Malley BW (1999) Progesterone via its receptor antagonizes the pro-inflammatory activity of estrogen in the mouse uterus. Biol Reprod 60(5):1158–1165. https://doi.org/10.1095/biolreprod60.5.1158
Upson K, Sathyanarayana S, De Roos AJ, Thompson ML, Scholes D, Dills R et al (2013) Phthalates and risk of endometriosis. Environ Res 126:91–97. https://doi.org/10.1016/j.envres.2013.07.003
Upson KSS, Scholes D, Holt VL (2015a) Early-life factors and endometriosis risk. Fertil Steril 104(4):964–971
Upson K, Sathyanarayana S, Scholes D, Holt VL (2015b) Early-life factors and endometriosis risk. Fertil Steril 104(4):964–71 e5. https://doi.org/10.1016/j.fertnstert.2015.06.040
Vezina CM, Lin TM, Peterson RE (2009) AHR signaling in prostate growth, morphogenesis, and disease. Biochem Pharmacol 77(4):566–576. https://doi.org/10.1016/j.bcp.2008.09.039
Yilmaz BD, Bulun SE (2019) Endometriosis and nuclear receptors. Hum Reprod Update 25(4):473–485. https://doi.org/10.1093/humupd/dmz005
Zhang T, De Carolis C, Man GCW, Wang CC (2018) The link between immunity, autoimmunity and endometriosis: a literature update. Autoimmun Rev 17(10):945–955. https://doi.org/10.1016/j.autrev.2018.03.017
Ziv-Gal A, Flaws JA (2016) Evidence for bisphenol A-induced female infertility: a review (2007–2016). Fertil Steril 106(4):827–856. https://doi.org/10.1016/j.fertnstert.2016.06.027
Acknowledgments
We gratefully acknowledge our research support from VA I01 BX002853, NIEHS ES14942, and EPA G13L10292. Additionally, Ms. Stephens is supported by the Vanderbilt University School of Medicine Training Program in Environmental Toxicology (TOX T32 ES007028) and Ms. Rumph by the Research Training Initiative for Student Enhancement (RISE) Program (5R25GM059994) to Meharry Medical School. We also gratefully acknowledge the assistance of Ms. Evelyn Hipp for contributing her artistic talent to Fig. 1.
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Rumph, J.T., Stephens, V.R., Archibong, A.E., Osteen, K.G., Bruner-Tran, K.L. (2020). Environmental Endocrine Disruptors and Endometriosis. In: Sharpe-Timms, K.L. (eds) Animal Models for Endometriosis. Advances in Anatomy, Embryology and Cell Biology, vol 232. Springer, Cham. https://doi.org/10.1007/978-3-030-51856-1_4
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