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A Novel Drug Delivery System for Amphotericin B to Treat Cutaneous Leishmaniasis

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Recent Advances in Environmental Science from the Euro-Mediterranean and Surrounding Regions (2nd Edition) (EMCEI 2019)

Part of the book series: Environmental Science and Engineering ((ENVSCIENCE))

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Abstract

Cutaneous Leishmaniasis is an infectious disease caused by leishmenia protozoan and pollution. This is why most developing countries such as India and South Africa suffer from its expansion. Even in Tunisia, an endemic situation was noticed. In this context, the aim of this study was to elaborate a suitable hydrogel to be used as drug carrier of Amphotericin B for antileishmanial treatment. Therefore, a radiation crosslinked Polyvinyl pyrrolidone (PVP) hydrogel was synthesized depending on the composition, with varying concentration of PVP, agar, and Polyethylene glycol (PEG) used as a plasticizer as a function of irradiation dose. The polymers were characterized using Infrared spectroscopy (FTIR), scanning electronic microscopy (SEM), and rheological measurements. Based on Elastic modulus, sample with 3% PEG was found to be fitter for wound dressing application. The putative antileishmanial and cytotoxic activity of this hydrogel was investigated. It has been shown that in the presence of hydrogel, the activity of Amphotericin on Leishmania promastigotes is markedly improved with an increase of selectivity index from 10.54 to 56.8.

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References

  1. Monge-Maillo, B., López-Vélez, R.: Therapeutic options for old world cutaneous leishmaniasis and new world cutaneous and mucocutaneous leishmaniasis. Drugs 73(17), 1889–920 (2013)

    Google Scholar 

  2. Lugao, A.B., Malmonge, M.: Rheological behaviour of irradiated wound dressing poly (vinyl pyrrolidone) hydrogels. Radiat. Phys. Chem. 63, 543–546 (2002)

    Article  CAS  Google Scholar 

  3. Gonz, P., Mar, C., Rodr, I., Jose, M., D, G., Manuel, S.: In vitro activity of C 20-diterpenoid alkaloid derivatives in promastigotes and intracellular amastigotes of Leishmania infantum. Int. J. Antimicrob. Agents 25, 136–141 (2005)

    Google Scholar 

  4. An, J., Weaver, A., Kim, B., Barkatt, A., Poster, D., Vreeland, W.N., Al-sheikhly, M.: Radiationinduced synthesis of poly (vinylpyrrolidone) nanogel. Polymer 52(25), 5746–5755 (2011)

    Article  CAS  Google Scholar 

  5. Abellan, M., Ayadh, M., Feulvarch, E., Zahouani, H.: Caractérisation des paramètres mécaniques de la peau humaine jeune in vivo par essais d’indentation sans contact 22 Ème Congrès Français de Mécanique (2015)

    Google Scholar 

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Authors and Affiliations

  1. Laboratory of Useful Materials Valuation, National Center for Research in Materials Sciences, Borj Cedria Technopark, BP 73, 8027, Soliman, Tunisia

    Nour Elhouda Benammar & Ahmed Hichem Hamzaoui

Authors
  1. Nour Elhouda Benammar
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  2. Ahmed Hichem Hamzaoui
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Corresponding author

Correspondence to Nour Elhouda Benammar .

Editor information

Editors and Affiliations

  1. High Institute of Biotechnology, University of Sfax, Sfax, Tunisia

    Mohamed Ksibi

  2. Appliquées et Technologies, Institut Supérieur des Sciences, Gabès, Tunisia

    Achraf Ghorbal

  3. University of Calabria, Rende, Cosenza, Italy

    Sudip Chakraborty

  4. School of Engineering (ISEP), Polytechnic of Porto, Porto, Portugal

    Helder I. Chaminé

  5. Università degli Studi di Roma, Roma, Roma, Italy

    Maurizio Barbieri

  6. University of Naples, Naples, Italy

    Giulia Guerriero

  7. High Institute of Biotechnology, University of Sfax, Sfax, Tunisia

    Olfa Hentati

  8. Faculty of Engineering, Water and Water Structure Engineering Department, Zagazig University, Zagazig, Egypt

    Abdelazim Negm

  9. University of Geneva, Genève, Geneve, Switzerland

    Anthony Lehmann

  10. ECT Oekotoxikologie GmbH, Flörsheim am Main, Hessen, Germany

    Jörg Römbke

  11. Centre for Environmental+Marine Studies, University of Aveiro, Aveiro, Portugal

    Armando Costa Duarte

  12. Department of Geography, Justus-Liebig-University Giessen, Gießen, Hessen, Germany

    Elena Xoplaki

  13. Springer Nature, Heidelberg, Baden-Württemberg, Germany

    Nabil Khélifi

  14. Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium

    Gilles Colinet

  15. University of Aveiro, Aveiro, Portugal

    João Miguel Dias

  16. Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia

    Imed Gargouri

  17. Institut de Physique du Globe de Paris, Université de Paris, Paris, France

    Eric D. Van Hullebusch

  18. FOTOAIR-CIEMAT, Madrid, Madrid, Spain

    Benigno Sánchez Cabrero

  19. Department of Civil Engineering, University of Salerno, Fisciano, Italy

    Settimio Ferlisi

  20. College of Engineering, Swansea University, Swansea, UK

    Chedly Tizaoui

  21. Sfax National School of Engineering, University of Sfax, Sfax, Tunisia

    Amjad Kallel

  22. Swiss Federal Institute of Technology, Lausanne, Switzerland

    Sami Rtimi

  23. Department of Mining Engineering, Suleyman Demirel University, Isparta, Turkey

    Sandeep Panda

  24. Université Clermont Auvergne, Polytech, Aubière, France

    Philippe Michaud

  25. Institute of Chemical Technology, University of Stuttgart, Stuttgart, Baden-Württemberg, Germany

    Jaya Narayana Sahu

  26. High School of Science and Technology, University of Sousse, Sousse, Tunisia

    Mongi Seffen

  27. SEED DICIV, University of Salerno, Fisciano, Italy

    Vincenzo Naddeo

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© 2021 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG

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Benammar, N.E., Hamzaoui, A.H. (2021). A Novel Drug Delivery System for Amphotericin B to Treat Cutaneous Leishmaniasis. In: Ksibi, M., et al. Recent Advances in Environmental Science from the Euro-Mediterranean and Surrounding Regions (2nd Edition). EMCEI 2019. Environmental Science and Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-030-51210-1_115

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