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Does Allergy Cause Chronic Rhinosinusitis with Nasal Polyps?

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Challenges in Rhinology

Abstract

Chronic rhinosinusitis (CRS) is a multifactorial disease due to chronic inflammation of sino-nasal mucosa that persists for more than 12 weeks. Since the first edition of EPOS guidelines, CRS has been divided into two main phenotypes: CRS with nasal polyposis (CRSwNP) and CRS without nasal polyposis (CRSsNP). In recent years, several authors agreed that CRS is not a uniform disease process but rather includes different phenotypes and endotypes. Differences may be observed in terms of risk factors, co-morbid conditions associated with CRS and disease control by medical treatment and surgery. The role of allergy in chronic rhinosinusitis (CRS) has been largely discussed in the literature, but nevertheless it remains controversial. Allergy and CRS are very prevalent diseases and frequently co-occur; however, direct causality has never been clearly demonstrated. Because the association between the two diseases has not been clear for years, making an evidence-based decision of whether to evaluate or treat allergies in CRS patients was difficult. Recently, it is clear that the prevalence of allergy is variable between the different subtypes of CRSwNP and the association seems to be very strong particularly with allergic fungal rhinosinusitis (AFRS) and central compartment atopic disease (CCAD).

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Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology, Konak Hospital, Kocaeli, Turkey

    Erkan Esen

  2. Otorhinolaryngology, Head and Neck Surgery, Agostino Gemelli Hospital Foundation IRCCS, Catholic University of the Sacred Heart, Rome, Italy

    Eugenio De Corso

  3. RNENT Hospital and University College, London, UK

    Glenis K. Scadding

Authors
  1. Erkan Esen
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  2. Eugenio De Corso
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  3. Glenis K. Scadding
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Editor information

Editors and Affiliations

  1. Department of Otolaryngology, Eskisehir Osmangazi University, Eskisehir, Turkey

    Cemal Cingi

  2. Otolaryngology Department, Kırıkkale University, Faculty Medicine, Kirikkale, Turkey

    Nuray Bayar Muluk

  3. Royal National ENT Hospital, London, UK

    Glenis K Scadding

  4. Croatian Academy of Medical Sciences, Zagreb, Croatia

    Ranko Mladina

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Esen, E., De Corso, E., Scadding, G.K. (2021). Does Allergy Cause Chronic Rhinosinusitis with Nasal Polyps?. In: Cingi, C., Bayar Muluk, N., Scadding, G.K., Mladina, R. (eds) Challenges in Rhinology. Springer, Cham. https://doi.org/10.1007/978-3-030-50899-9_10

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  • DOI: https://doi.org/10.1007/978-3-030-50899-9_10

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