Abstract
Self-assembling lipid nanoparticle systems come in a variety of structural arrangements, sizes, morphologies, and compositions. Lipid nanoparticles have become a significant option to increase the stability and control the release of many active compounds of interest for pharmaceutical and food and beverage industries allowing the development of safer and more effective formula or products. A comprehensive summary of self-assembling nanoparticle systems is beneficial for the nanoparticle field, both academic and professional toward aiding awareness of the subject and its benefits. An overview of self-assembling lipid nanoparticle systems is presented with emphasis on nanostructures, properties, production methods, and key characteristics of importance for industrial applications. Special emphasis is placed on lamellar phase dispersions, termed liposomes, relevant properties, long history of use, and their key role as vehicle of a variety of therapeutic agents. Additional details of each characteristic of self-assembling lipid nanoparticle systems are presented along with information regarding benefits of particular self-assembling lipid nanoparticle systems. Examples of the self-assembling lipid nanoparticle systems within various industrial sectors including pharmaceutical, cosmetic, nutraceutical, and food and beverage are described, as well as the relevance of self-assembling lipid nanoparticle systems within the particular industrial segment. Additionally, details of value and/or benefit to the specific industrial segment are presented.
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References
Alavi M, et al. Application of various types of liposomes in drug delivery systems. Adv Pharm Bull. 2017;7(1):3–9. https://doi.org/10.15171/apb.2017.002.
Alberts B, Johnson A, Lewis J, et al. Molecular biology of the cell. 4th ed. New York: Garland Science; 2002. The lipid bilayer. Available from: https://www.ncbi.nlm.nih.gov/books/NBK26871/
Alkilany AM, Murphy CJ. Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? J Nanoparticle Res. 2010;12(7):2313–2333. Retrieved on 17 February 2020 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988217/
Ashtiani H, Reza A, et al. Liposomes in cosmetics. J Skin Stem Cell. 2016;3(3) https://doi.org/10.5812/jssc.65815.
Bangham AD, Horne RW. Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope. J Mol Biol. 1964;8:660–8.
Barauskas J, Johnsson M, Tiberg F. Self-assembled lipid superstructures: beyond vesicles and liposomes. Nano Lett. 2005;5(8):1615–9.
Beg S, Swain S, Rizwan M, Irfanuddin M, Malini DS. Bioavailability enhancement strategies: basics, formulation approaches and regulatory considerations. Curr Drug Delivery. 2011;8 6:691–702. https://doi.org/10.2174/156720111797635504. Retrieved on 13 February 2020 from https://sci-hub.tw/10.2174/156720111797635504
Berger M. Nanotechnology in food, Nanowerk, 24 Apr. 2019; (2019). www.nanowerk.com/nanotechnology-in-food.php
Cooper GM. The cell: a molecular approach. 2nd ed. Sunderland: Sinauer Associates; 2000. Cell membranes. Available from: https://www.ncbi.nlm.nih.gov/books/NBK9928/
Deepak S, Singh M, Kumar D, Singh G, Rarthore MS. Taste masking technologies: a novel approach for the improvement of organoleptic property of pharmaceutically active substance. Int Res J Pharm. 2012;3(4):108–116. Retrieved on 13 February 2020 from https://www.researchgate.net/publication/236152461_Taste_Masking_Technologies_A_Novel_Approach_for_the_improvement_of_Organoleptic_Property_of_Pharmaceutically_Active_Substance
Elsohly MA, et al. Phytochemistry of Cannabis sativa L. Prog Chem Org Nat Prod. 2017;103:1–36. https://doi.org/10.1007/978-3-319-45541-9_1.
FDA Inactive Ingredients Database. 2020. Retrieved on 11 February 2020 from https://www.accessdata.fda.gov/scripts/cder/iig/index.cfm?event=BasicSearch.page
Foti D. Investigation of the effects of moisturizers on the biomechanical skin properties of hydration and elasticity for the hairless mouse. Master’s thesis – University of South Florida; 1998.
Friberg SE, et al. Water permeation of reaggregated stratum corneum with model lipids. J Investig Dermatol. 1990;94(3):377–80. https://doi.org/10.1111/1523-1747.ep12874497.
Frozun Spirits Infused Desserts & Cocktails. Frozun Spirits Infusion; 2018. 28 Dec. 2018, www.frozun.com/
Gala U, Chauhan H. Taste masking techniques in the pharmaceutical industry. Am Pharm Rev. 2014. Retrieved on 13 February 2020 from https://www.americanpharmaceuticalreview.com/Featured-Articles/163483-Taste-Masking-Techniques-in-the-Pharmaceutical-Industry/
Gharbavi M, et al. Niosome: a promising nanocarrier for natural drug delivery through blood-brain barrier. Adv Pharmacol Sci. 2018:1–15. https://doi.org/10.1155/2018/6847971.
Grice K, Bettley FR. The effect of skin temperature and vascular change on the rate of transepidermal water loss. Br J Dermatol, U.S. National Library of Medicine, Nov. 1967; 1967. www.ncbi.nlm.nih.gov/pubmed/6072763
Hasibi F, et al. Formulation and characterization of taxifolin-loaded lipid nanovesicles (liposomes, niosomes, and transfersomes) for beverage fortification. Eur J Lipid Sci Technol. 2019;122(2):1900105. https://doi.org/10.1002/ejlt.201900105.
Huestis MA. Human cannabinoid pharmacokinetics. Chem Biodivers Wiley Online Library;(2007. onlinelibrary.wiley.com/doi/https://doi.org/10.1002/cbdv.200790152/references
Jeevanandam J, Barhoum A, ChanYS, Dufresne A, Danquah MK. Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations. Beilstein J Nanotechnol. 2018;9:1050–1074. Retrieved on 13 February 2020 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905289/
Kono K. Thermosensitive polymer-modified liposomes. Adv Drug Deliv Rev. 2001;53(3):307–319. https://doi.org/10.1016/S0169-409X(01)00204-6. Retrieved on 13 February 2020 from https://www.sciencedirect.com/science/article/abs/pii/S0169409X01002046
Kulkarni CV. Lipid self-assemblies and nanostructured emulsions for cosmetic formulations. Cosmetics. 2016;3:37. https://doi.org/10.3390/cosmetics3040037.
Kullenberg D, Taylor LA, Schneider M, Massing U. Health effects of dietary phospholipids. Lipids Health Dis. 2012;11(3):1–34. Retrieved on 11 February 2020 from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316137/
Laurentiis A, et al. Role of the endocannabinoid system in the neuroendocrine responses to inflammation. Curr Pharm Des. 2014;20(29):4697–706. https://doi.org/10.2174/1381612820666140130212957.
Luzzati V, Husson F. The structure of the liquid-crystalline phases of lipid-water systems. J Cell Biol. 1962;12:207–19.
Maherani B, Arab-Tehrany E, Mozafari MR, Gaiani C, Linder M. Liposomes: a review of manufacturing techniques and targeting strategies. Curr Nanosci. 2011;7:436–52.
Pawar AY, Jadhav KR, Chaudhari LH. Transfersome: a novel technique which improves transdermal permeability. Asian J Pharm. 2016;10(4):S425.
Puglia C, Santonocito D. Cosmeceuticals: nanotechnology-based strategies for the delivery of phytocompounds. Curr Pharm Des. 2019;25(21):2314–22. https://doi.org/10.2174/1381612825666190709211101.
Rai R, Alwani S, Badea I. Polymeric nanoparticles in gene therapy: new avenues of design and optimization for delivery applications. Polymers. 2019;11:745. https://doi.org/10.3390/polym11040745.
Roos YH, Livney YD. Chapter 5: Nanoencapsulation technologies. In: Engineering foods for bioactives stability and delivery. New York: Springer; 2017. p. 143–69.
Rowat P, et al. Nanoemulsion: the hottest new trend in the Cannabis beverages industry; 2019. Greencamp, greencamp.com/nanoemulsion-the-hottest-new-trend-in-the-cannabis-beverages-industry/
Sajal JK, Uday SR, Surrendra V. Taste masking in pharmaceuticals: an update. J Pharm Res. 2008;1(2):126–30. Retrieved 20 February 2020 from https://www.researchgate.net/publication/38109421_Taste_masking_in_pharmaceuticals_An_update
Savjan KT, Gajjar AK, Savjani JK. Drug solubility: importance and enhancement techniques. Int Scholar Res Notices Pharma. 2012;2012:1–10. https://doi.org/10.5402/2012/195727. Retrieved on 13 February 2020 from https://www.hindawi.com/journals/isrn/2012/195727/
Seleci DA, Seleci M, Walter J-G, Stahl F, Scheper T. Niosomes as nanoparticular drug carriers: fundamentals and recent applications. J Nanomater. 2016;2016:Article ID 7372306, 13 pages.
Sercombe L, et al. Advances and challenges of liposome assisted drug delivery. Front Pharmacol. 2015;6:286. https://doi.org/10.3389/fphar.2015.00286.
Shafiqa AR, Aziz AA, Mehrdel B. Nanoparticle optical properties: size dependence of a single gold spherical nanoparticle. J Phys Conf Ser. 2018;1083:1–6. https://doi.org/10.1088/1742-6596/1083/1/012040. Retrieved on 13 February 2020 from https://iopscience.iop.org/article/10.1088/1742-6596/1083/1/012040/pdf
Shanmugam T, Banerjee R. Nanostructured self assembled lipid materials for drug delivery and tissue engineering. Ther Deliv. 2011;2(11):1485–516.
Shukla S, Haldorai Y, Hwang SK, Bajpai VK, Huh YS, Han Y-K. Current demands for food-approved liposome nanoparticles in food and safety sector. Front Microbiol. 2017;8:Article 239805. https://doi.org/10.3389/fmicb.2017.02398.
Tan A, Hong L, Du JD, Boyd BJ. Self-assembled nanostructured lipid systems: is there a link between structure and cytotoxicity? Adv Sci. 2018;6(3):1801223.
Tiju J, Morrison M. Nanotechnology applications in food and agriculture. Institute of Nanotechnology; 2006. p. 2–14.
US Patent 8,597,678. Nanolipidic particles. Issued 22 December 2006. Retrieved on 17 February 2020 from https://patents.justia.com/patent/8597678
Verma, Pathak K. Therapeutic and cosmeceutical potential of ethosomes: an overview. J Adv Pharm Technol Res. 2010;1(3):274–82.
Waterhouse DN, et al. A comparison of liposomal formulations of doxorubicin with drug administered in free form. Drug Saf. 2001;24(12):903–20. https://doi.org/10.2165/00002018-200124120-00004.
Wu W, et al. Oral delivery of liposomes. Ther Deliv. 2015;6(11):1239–41. https://doi.org/10.4155/tde.15.69.
Yadav AV, Murthy MS, Shete AS, Sakhare S. Stability aspects of liposomes. Indian J Pharm Educ Res. 2011;45(4):402–413. Retrieved on 13 February 2020 from http://www.ijper.org/sites/default/files/IJPER_45_4_13.pdf
Yu H, Park J-Y, Kwon C W, Hong S-C, Park K-M, Chang P-S. An overview of nanotechnology in food science: preparative methods, practical applications, and safety. J Chem. 2018; 2018:Article ID 5427978, 10 pages https://doi.org/10.1155/2018/5427978.
Zucker D, Marcus D, Barenholz Y, Goldblum A. Liposome drugs’ loading efficiency: a working model based on loading conditions and drug’s physicochemical properties. J Control Release. 2009;139(1):73–80. https://doi.org/10.1016/j.jconrel.2009.05.036. Retrieved on 13 February 2020 from sci-hub.tw/10.1016/j.jconrel.2009.05.036
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Reynolds, J.S., McCardy, N., Bejarano, J., Duffey, D. (2021). Self-Assembling Lipid Nanoparticles/Nanosystems (SLNN) Using Hydrophilic Solvents: Overview and Industrial Uses. In: Patel, J.K., Pathak, Y.V. (eds) Emerging Technologies for Nanoparticle Manufacturing. Springer, Cham. https://doi.org/10.1007/978-3-030-50703-9_16
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