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Use of Botulinum Toxin A in Postmastectomy Breast Reconstruction

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Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine

Abstract

Botulinum toxin A has been successfully used in a variety of areas to temporarily obliterate muscle mobility for either functional or aesthetic gain. Tissue expander-based breast reconstruction has been plagued with pain and discomfort. This chapter describes the use of botulinum toxin A in managing pain and discomfort in the breast reconstruction patients.

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References

  1. American society of plastic surgeons 2013 plastic surgery statistics report 2013. Accessed 22 Dec 2014, at http://www.plasticsurgery.org/Documents/news-resources/statistics/2013-statistics/plastic-surgery-statistics-full-report-2013.pdf.

  2. Disa JJ, Ad-El DD, Cohen SM, Cordeiro PG, Hidalgo DA. The premature removal of tissue expanders in breast reconstruction. Plast Reconstr Surg. 1999;104:1662–5.

    Article  CAS  Google Scholar 

  3. Legeby M, Segerdahl M, Sandelin K, Wickman M, Ostman K, Olofsson C. Immediate reconstruction in breast cancer surgery requires intensive post-operative pain treatment but the effects of axillary dissection may be more predictive of chronic pain. Breast. 2002;11:156–62.

    Article  CAS  Google Scholar 

  4. May JW Jr, Bucky LP, Sohoni S, Ehrlich HP. Smooth versus textured expander implants: a double-blind study of capsule quality and discomfort in simultaneous bilateral breast reconstruction patients. Ann Plast Surg. 1994;32:225–32; discussion 32–3

    Article  Google Scholar 

  5. McCarthy CM, Cordeiro PG, Disa JJ, Mehrara BJ, Pusic AL. The impact of breast reconstruction on the oncologic efficacy of radiation therapy. Ann Plast Surg. 2008;61:585.

    Article  CAS  Google Scholar 

  6. Pusic AL, Cordeiro PG. An accelerated approach to tissue expansion for breast reconstruction: experience with intraoperative and rapid postoperative expansion in 370 reconstructions. Plast Reconstr Surg. 2003;111:1871–5.

    Article  Google Scholar 

  7. Raposio E, Santi PL. Topical application of DMSO as an adjunct to tissue expansion for breast reconstruction. Br J Plast Surg. 1999;52:194–7.

    Article  CAS  Google Scholar 

  8. Sinow JD, Cunningham BL. Intraluminal lidocaine for analgesia after tissue expansion: a double-blind prospective trial in breast reconstruction. Ann Plast Surg. 1992;28:320–5.

    Article  CAS  Google Scholar 

  9. Turan Z, Sandelin K. Local infiltration of anaesthesia with subpectoral indwelling catheters after immediate breast reconstruction with implants: a pilot study. Scand J Plast Reconstr Surg Hand Surg. 2006;40:136–9.

    Article  Google Scholar 

  10. Meng J, Wang J, Lawrence G, Dolly JO. Synaptobrevin I mediates exocytosis of CGRP from sensory neurons and inhibition by botulinum toxins reflects their anti-nociceptive potential. J Cell Sci. 2007;120:2864–74.

    Article  CAS  Google Scholar 

  11. Mustafa G, Anderson EM, Bokrand-Donatelli Y, Neubert JK, Caudle RM. Anti-nociceptive effect of a conjugate of substance P and light chain of botulinum neurotoxin type A. Pain. 2013;154:2547–53.

    Article  CAS  Google Scholar 

  12. Dodick DW, Turkel CC, DeGryse RE, et al. OnabotulinumtoxinA for treatment of chronic migraine: pooled results from the double-blind, randomized, placebo-controlled phases of the PREEMPT clinical program. Headache. 2010;50:921–36.

    Article  Google Scholar 

  13. Abbott JA, Jarvis SK, Lyons SD, Thomson A, Vancaille TG. Botulinum toxin type A for chronic pain and pelvic floor spasm in women: a randomized controlled trial. Obstet Gynecol. 2006;108:915–23.

    Article  Google Scholar 

  14. Placzek R, Drescher W, Deuretzbacher G, Hempfing A, Meiss AL. Treatment of chronic radial epicondylitis with botulinum toxin A. A double-blind, placebo-controlled, randomized multicenter study. J Bone Joint Surg Am. 2007;89:255–60.

    Article  Google Scholar 

  15. Singh JA, Mahowald ML, Noorbaloochi S. Intraarticular botulinum toxin A for refractory painful total knee arthroplasty: a randomized controlled trial. J Rheumatol. 2010;37:2377–86.

    Article  Google Scholar 

  16. Foster L, Clapp L, Erickson M, Jabbari B. Botulinum toxin A and chronic low back pain: a randomized, double-blind study. Neurology. 2001;56:1290–3.

    Article  CAS  Google Scholar 

  17. Lang AM. Botulinum toxin therapy for myofascial pain disorders. Curr Pain Headache Rep. 2002;6:355–60.

    Article  Google Scholar 

  18. Tan EK, Jankovic J. Treating severe bruxism with botulinum toxin. J Am Dent Assoc. 2000;131:211–6.

    Article  CAS  Google Scholar 

  19. Layeeque R, Hochberg J, Siegel E, et al. Botulinum toxin infiltration for pain control after mastectomy and expander reconstruction. Ann Surg. 2004;240:608–13; discussion 13–4.

    PubMed  PubMed Central  Google Scholar 

  20. Figus A, Mazzocchi M, Dessy LA, Curinga G, Scuderi N. Treatment of muscular contraction deformities with botulinum toxin type A after latissimus dorsi flap and sub-pectoral implant breast reconstruction. J Plast Reconstr Aesthet Surg. 2009;62:869–75.

    Article  Google Scholar 

  21. Zhibo X, Miaobo Z. Botulinum toxin type A infiltration for pain control after breast augmentation. Plast Reconstr Surg. 2009;124:263e–4e.

    Article  Google Scholar 

  22. Ferraro G, Altieri A, Grella E, D’Andrea F. Botulinum toxin: 28 patients affected by Frey’s syndrome treated with intradermal injections. Plast Reconstr Surg. 2005;115:344–5.

    CAS  PubMed  Google Scholar 

  23. Gabriel A, Champaneria MC, Maxwell GP. The efficacy of botulinum toxin A in post-mastectomy breast reconstruction: a pilot study. Aesthet Surg J. 2015;35:402–9.

    Article  Google Scholar 

  24. Jabbari B. Botulinum neurotoxins in the treatment of refractory pain. Nat Clin Pract Neurol. 2008;4:676–85.

    Article  CAS  Google Scholar 

  25. Jankovic J, Schwartz K. Botulinum toxin injections for cervical dystonia. Neurology. 1990;40:277–80.

    Article  CAS  Google Scholar 

  26. Gobel H, Heinze A, Heinze-Kuhn K, Jost WH. Evidence-based medicine: botulinum toxin A in migraine and tension-type headache. J Neurol. 2001;248(Suppl 1):34–8.

    Article  CAS  Google Scholar 

  27. Cui M, Li Z, You S, Khanijou S, Aoki K. Mechanisms of the antinociceptive effect of subcutaneous Botox: inhibition of peripheral and central nociceptive processing. Arch Pharmacol. 2002;365:R17.

    Article  Google Scholar 

  28. Singh JA. Botulinum toxin therapy for osteoarticular pain: an evidence-based review. Ther Adv Musculoskelet Dis. 2010;2:105–18.

    Article  CAS  Google Scholar 

  29. Jost W. Pictorial atlas of botulinum toxin injection: dosage, localization, application. Germany: Quintessence Pub Co; 2012.

    Google Scholar 

  30. Sigalove S, Maxwell GP, Sigalove NM, et al. Prepectoral implant-based breast reconstruction and postmastectomy radiotherapy: short-term outcomes. Plast Reconstr Surg Glob Open. 2017;5:e1631.

    Article  Google Scholar 

  31. Altieri A, Brongo S, Mele CM, Amoroso A, D’Andrea F. The botulinum toxin in breast reconstruction. Rivista Italiana di Chirurgia Plastica. 2006;38:127–30.

    Google Scholar 

  32. Boneti C, Yuen J, Santiago C, et al. Oncologic safety of nipple skin-sparing or total skin-sparing mastectomies with immediate reconstruction. J Am Coll Surg. 2011;212:686–93; discussion 93–5.

    Article  Google Scholar 

  33. Smoot D, Zielinski M, Jenkins D, Schiller H. Botox A injection for pain after laparoscopic ventral hernia: a case report. Pain Med. 2011;12:1121–3.

    Article  Google Scholar 

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Gabriel, A., Maxwell, G.P. (2020). Use of Botulinum Toxin A in Postmastectomy Breast Reconstruction. In: Jabbari, B. (eds) Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-50691-9_9

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