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Botulinum Toxin Treatment in Plastic Surgery

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Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine

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Abstract

Injectable botulinum toxin type A is currently the leading plastic surgery procedure and its popularity continues to rise year after year. Botulinum toxin’s use within the field of plastic surgery is summarized in this chapter and will outline guidelines for its use on targeting specific rhytides of the face, modification of facial form, improvement of skin quality, scar management, and salivary gland hypertrophy.

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References

  1. ASPS. Plastic surgery statistics report 2018.

    Google Scholar 

  2. Monheit G. Neurotoxins: current concepts in cosmetic use on the face and neck-upper face (glabella, forehead, and crow’s feet). Plast Reconstr Surg. 2015;136(5):72S–5S. https://doi.org/10.1097/PRS.0000000000001771.

    Article  CAS  PubMed  Google Scholar 

  3. Sposito M. New indications for botulinum toxin type a in cosmetics: mouth and neck. Plast Reconstr Surg. 2002;110(2):601–11.

    Article  PubMed  Google Scholar 

  4. Matarasso A, Matarasso SL, Brandt FS, Bellman B. Botulinum A exotoxin for the management of platysma bands. Plast Reconstr Surg. 1999;103:645–52; discussion 653–655.

    Article  CAS  PubMed  Google Scholar 

  5. Bae GY, Yune YM, Seo K, Il HS. Botulinum toxin injection for salivary gland enlargement evaluated using computed tomographic volumetry. Dermatologic Surg. 2013;39(9):1404–7. https://doi.org/10.1111/dsu.12247.

    Article  CAS  Google Scholar 

  6. Hui JI, Lee WW. Efficacy of fresh versus refrigerated botulinum toxin in the treatment of lateral periorbital rhytids. Ophthal Plast Reconstr Surg. 2007;23(6):433–8. https://doi.org/10.1097/IOP.0b013e31815793b7.

    Article  PubMed  Google Scholar 

  7. Noland ME, Lalonde DH, Yee GJ, Rohrich RJ. Current uses of botulinum neurotoxins in plastic surgery. Plast Reconstr Surg. 2016;138(3):519e–30e.

    Article  CAS  PubMed  Google Scholar 

  8. de Maio M, Swift A, Signorini M, Fagien S. Facial assessment and injection guide for botulinum toxin and injectable hyaluronic acid fillers: focus on the upper face. Plast Reconstr Surg. 2017;140(2):265e–76e.

    Article  PubMed  CAS  Google Scholar 

  9. Jaspers G, Pijpe J, Jansma J. The use of botulinum toxin type A in cosmetic facial procedures. Int J Oral Maxillofac Surg. 2011;40:127–33.

    Article  CAS  PubMed  Google Scholar 

  10. de Maio M, Rzany B. Botulinum toxin in aesthetic medicine. Berlin/Heidelberg: Springer-Verlag; 2009.

    Google Scholar 

  11. Wu DC, Fabi SG, Goldman MP. Neurotoxins: current concepts in cosmetic use on the face and neck-lower face. Plast Reconstr Surg. 2015;136(5):76S–9S.

    Article  CAS  PubMed  Google Scholar 

  12. Jain P, Rathee M. Anatomy, head and neck, orbicularis oris muscle. StatPearls. 2019.

    Google Scholar 

  13. de Maio M, Wu WTL, Goodman GJ, Monheit G. Facial assessment and injection guide for botulinum toxin and injectable hyaluronic acid fillers: focus on the lower face. Plast Reconstr Surg. 2017;140(3):393e–404e.

    Article  PubMed  CAS  Google Scholar 

  14. Cohen J, Dayan S, Cox S. OnabotulinumtoxinA dose-ranging study for hyperdynamic perioral lines. Dermatol Surg. 2012;38:1497–505.

    Article  CAS  PubMed  Google Scholar 

  15. Yun S, Son D, Yeo H, et al. Changes of eyebrow muscle activity with aging: functional analysis revealed by electromyography. Plast Reconstr Surg. 2014;133(4):455–63.

    Article  CAS  Google Scholar 

  16. Tong J, BC Patel. Anatomy, head and neck, eye orbicularis oculi muscle. StatPearls. 2019.

    Google Scholar 

  17. Deka A, Saikia SP. Botulinum toxin for lower lid entropion correction. Orbit. 2011;30(1):40–2.

    Article  PubMed  Google Scholar 

  18. Carruthers JD, Glogau RG, Blitzer A, Facial Aesthetics Consensus Group Faculty. Advances in facial rejuvenation: botulinum toxin type a, hyaluronic acid dermal fillers, and combination therapies. Consensus recommendations. Plast Reconstr Surg. 2008;121(5):5S–30S.

    Article  CAS  PubMed  Google Scholar 

  19. Hur MS, Kim HJ, Choi BY, Hu KS, Kim HJ, Lee KS. Morphology of the mentalis muscle and its relationship with the orbicularis oris and incisivus labii inferioris muscles. J Craniofac Surg. 2013;24(2):602–4.

    Article  PubMed  Google Scholar 

  20. Kane MAC. The functional anatomy of the lower face as it applies to rejuvenation via chemodenervation. Facial Plast Surg. 2005;21(1):55–64.

    Article  CAS  PubMed  Google Scholar 

  21. Wu WT. Botox facial slimming/facial sculpting: the role of botulinum toxin-a in the treatment of hypertophic masseteric muscle and parotid enlargement to narrow the lower facial width. Facial Plast Surg Clin N Am. 2010;18:133–40.

    Article  Google Scholar 

  22. Levy PM. Neurotoxins: current concepts in cosmetic use on the face and neck-jawline contouring/platysma bands/necklace lines. Plast Reconstr Surg. 2015;136(5):80S–3S.

    Article  CAS  PubMed  Google Scholar 

  23. Sandulescu T, Stoltenberg F, Buechner H, et al. Platysma and the cervical superficial musculoaponeurotic system — comparative analysis of facial crease and platysmal band development. Ann Anat. 2019;227:151414.

    Article  PubMed  Google Scholar 

  24. Trévidic P, Criollo-Lamilla G. Platysma bands: is a change needed in the surgical paradigm? Plast Reconstr Surg. 2017;139(1):41–7.

    Article  PubMed  CAS  Google Scholar 

  25. Carruthers J, Carruthers A. Aesthetic botulinum A toxin in the mid and lower face and neck. Dermatol Surg. 2003;29:468–76.

    PubMed  Google Scholar 

  26. Awaida CJ, Jabbour SF, Rayess YA, El Khoury JS, Kechichian EG, Nasr MW. Evaluation of the microbotox technique: an algorithmic approach for lower face and neck rejuvenation and a crossover clinical trial. Plast Reconstr Surg. 2018;142(3):640–9.

    Article  CAS  PubMed  Google Scholar 

  27. Wu W. Microbotox of the lower face and neck: evolution of a personal technique and its clinical effects. Plast Reconstr Surg. 2015;136(5 Suppl):92S–100S.

    Article  CAS  PubMed  Google Scholar 

  28. El ME, Hussien TM, Maksoud OMA. Needling combined with intralesional corticosteroid injections compared to Intralesional botulinum toxin a injections in the treatment of hypertrophic scars and. J Dermatology Plast Surg. 2019;3(1):1–6.

    Google Scholar 

  29. Scala J, Vojvodic A, Vojvodic P, et al. Botulin toxin use in scars/keloids treatment botulin toxin use in scars/keloids treatment. Maced J Med Sci. 2019;7(18):2979.

    Article  Google Scholar 

  30. Yang W, Li G. The safety and efficacy of botulinum toxin type A injection for postoperative scar prevention: a systematic review and meta-analysis. J Cosmet Dermatol. 2020;19(4):799–808.

    Article  PubMed  Google Scholar 

  31. Xiao Z, Zhang F, Lin W, Zhang M, Liu Y. Effect of botulinum toxin type A on transforming growth factor beta1 in fibroblasts derived from hypertrophic scar: a preliminary report. Aesthet Plast Surg. 2010;34(4):424–7.

    Article  Google Scholar 

  32. Jeong HS, Lee BH, Sung HM, et al. Effect of botulinum toxin type A on differentiation of fibroblasts derived from scar tissue. Plast Reconstr Surg. 2015;136(2):171e–8e.

    Article  CAS  PubMed  Google Scholar 

  33. Huang C, Akaishi S, Hyakusoku H, Ogawa R. Are keloid and hypertrophic scar different forms of the same disorder? A fibroproliferative skin disorder hypothesis based on keloid findings. Int Wound J. 2014;11(5):517–22.

    Article  PubMed  Google Scholar 

  34. Kellogg D, Pergola P, Piest K, et al. Cutaneous active vasodilation in humans is mediated by cholinergic nerve cotransmission. Circ Res. 1995;77:1222–8.

    Article  CAS  PubMed  Google Scholar 

  35. Uyesugi B, Lippincott B, Dave S. Treatment of painful keloid with botulinum toxin type A. Am J Phys Med Rehabil. 2010;89:153–5.

    Article  PubMed  Google Scholar 

  36. Li Y, Yang J, Liu J, et al. A randomized, placebo-controlled, double-blind, prospective clinical trial of botulinum toxin type A in prevention of hypertrophic scar development in median sternotomy wound. Aesthet Plast Surg. 2018;42:1364–9.

    Article  Google Scholar 

  37. Gugerell A, Kober J, Schmid M. Botulinum toxin A: dose- dependent effect on reepithelialization and angiogenesis. Plast Reconstrive Surg Glob Open. 2016;4:e837.

    Article  Google Scholar 

  38. Teymoortash A, Sommer F, Mandic R, Schulz S, Teymoortash A, Sommer F, Mandic R, Schulz S, et al. Intraglandular application of botulinum toxin leads to structural and functional changes in rat acinar cells. Br J Pharmacol. 2007;152:161–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Lakraj AA, Moghimi N, Jabbari B. Sialorrhea: Anatomy, pathophysiology and treatment with emphasis on the role of botulinum toxins. Toxins (Basel). 2013;5(5):1010–31. https://doi.org/10.3390/toxins5051010.

    Article  CAS  Google Scholar 

  40. Chen S, Paul BC, Myssiorek D. An algorithm approach to diagnosing bilateral parotid enlargement. Otolaryngol – Head Neck Surg. 2013;148(5):732–9.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Plastic Surgery, University of Toronto, Toronto, Canada

    Marie E. Noland

  2. Division of Plastic Surgery, Dalhousie University, Halifax, Canada

    Steven F. Morris

Authors
  1. Marie E. Noland
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  2. Steven F. Morris
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Editor information

Editors and Affiliations

  1. Professor Emeritus of Neurology, Yale University School of Medicine, New Haven, CT, USA

    Bahman Jabbari

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Noland, M.E., Morris, S.F. (2020). Botulinum Toxin Treatment in Plastic Surgery. In: Jabbari, B. (eds) Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-50691-9_12

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