Skip to main content

Drug Delivery from Ophthalmic Lenses

  • Chapter
  • First Online:
Mathematical Modelling in Real Life Problems

Part of the book series: Mathematics in Industry ((TECMI,volume 33))

  • 649 Accesses

Abstract

Glaucoma is one of the most common diseases that is characterized by an increase of the IOP that can lead to the damage of the optical nerve. Glaucoma patients are usually treated with eye drops. However, the effectiveness of glaucoma drops is very law because less than 5% of the applied drug reaches the target. In this paper, we discuss mathematically the use of therapeutic contact lenses to deliver drugs to the anterior chamber of the eye reviewing some of the recent contributions.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Bourlais, C., Acar, L., Sado, O., Needham, T., Leverge, R.: Ophthalmic drug delivery systems–recen tadvances. Prog. Ret. Eye Res. 17, 33–58 (1998)

    Article  Google Scholar 

  2. Braakman, S., Pedrigi, R., Read, A., Smith, J., Stamer, W., Ethier, C., Overby, D.: Biomechanical strain as a trigger for pore formation in schlemm’s canal endothelial cells. Exp. Eye Res. 127, 224–235 (2014)

    Article  Google Scholar 

  3. Chader, G., Thassu, D.: Eye anatomy, physiology, and ocular barriers. Basic considerations for drug delivery. In : Ocular Drug Delivery Systems: Barriers and Application of Nanoparticulate Systems, Thassu. D., Chader, G., (eds), 17–40, CRC Press, London—New–York (2012)

    Google Scholar 

  4. Ciolino J., Hoare, T., Iwata, N., Behlau, I., Dohlman, C., Langer, R., Kohane, D.: A drug-eluting contact lens. Invest. Ophthal. Visual Sci. 50,3346–3352 (2009)

    Article  Google Scholar 

  5. Ferreira, J.A., Oliveira, P., Silva, P., Carreira, A., Gil, H., Murta, J.: Sustained drug release from contact lens. Comp. Model. Eng. Sci. 60, 151–179 (2010)

    Google Scholar 

  6. Ferreira, J.A., Oliveira, P., Silva, P., Murta, J.: Drug delivery: from contact lens to the anterior chamber. Comp. Model. Eng. Sci. 71, 1–14 (2011)

    MathSciNet  MATH  Google Scholar 

  7. Ferreira, J.A., Oliveira, P., Silva, P.: Controlled drug delivery and medical applications. Chem. Biochem. Eng. Q. 26, 331–342 (2012)

    Google Scholar 

  8. Ferreira, J.A., Oliveira, P., Silva, P., Murta, J.: Numerical simulation of aqueous humor flow: from healthy to pathologic situations. App. Math. Comp. 226, 777–792 (2014)

    Article  MathSciNet  Google Scholar 

  9. Ferreira, J. A.: Drug delivery from ophthalmic lenses. In: Mathematics with Industry: Driving Innovation, ECMI Annual Report 2016, 34–42 (2016)

    Google Scholar 

  10. Goel, M., Picciani, R., Lee, R., Bhattacharya, S.: Aqueous humour dynamics: a review. Open Ophthalmol. J. 52,52–59 (2010)

    Article  Google Scholar 

  11. Gulsen, D., Chauhan, A., Ophthalmic drug delivery from contact lens. Invest. Ophthal. Visual Sci. 45, 2342–2347 (2004)

    Article  Google Scholar 

  12. Gulsen, D., Chauhan, A.: Dispersion of microemulsions drops in HEMA hydrogel: a potential ophthalmic drug delivery vehicle. Int. J. Pharm. 292, 95–117 (2005)

    Article  Google Scholar 

  13. Jung, H., Jaoude, M., Carbia, B., Plummer, C., Chauhan, A.: Glaucoma therapy by extended release of timolol from nanoparticle loaded silicone–hydrogel contact lenses. J. Control. Release 165, 82–89 (2013)

    Article  Google Scholar 

  14. Keller, K., Acot, T.: The juxtacanalicular region of ocular trabecular meshwork: a tissue with a unique extracellular matrix and specialized function. Journal of Ocular Biology 1,1–7 (2013)

    Google Scholar 

  15. Kiel,J., Hollingsworth, M., Rao, R., Chen, M., Reitsamer, H.: Ciliary blood flow and aqueous humor production. Prog. Ret. Eye Res. 30,1–17 (2011)

    Article  Google Scholar 

  16. Overby, D., Zhou, E., Vargas-Pinto, R., Pedrigi, R., Fuchshofer, R., Braakman, S., Gupta, R., Sherwood, J., Vahabikashi, A., Dang, Q., Kim, J., Ethier, R., Stamer, W., Fredberg, J., Johnson, M.: Altered mechanobiology of schlemm’s canal endothelial cells in glaucoma. Proc. Nat. Acad. Sci. 111, 13876–13881 (2014)

    Article  Google Scholar 

  17. McLan, N., Moroi, S.: Clinical implications of pharmacogenetics for glaucoma. Pharmacogenomics J. 30, 197–201 (2003)

    Article  Google Scholar 

  18. Nakada, K., Sugiyama, A.: Process for producing controlled drug-release contact lens, and controlled drug-release contact lens thereby produced. United States Patents, page 6027745 (1998)

    Google Scholar 

  19. Rupenthal, I.: Ocular drug delivery technologies: Exciting times ahead. ONdrugDelivery 54, 7–11 (2015)

    Google Scholar 

  20. Santos, J., Alvarez-Lorenzo, C., Silva, M., Balsa, L., Couceiro, J., Torres-Labandeira, J., Concheiro, A.: Soft contact lenses functionalized with pendant cyclodextrins for controlled drug delivery. Biomaterials 30, 1348–1355 (2009)

    Article  Google Scholar 

  21. Xinming, L., Yingde, C., Lloyd, A., Mikhalovsky, S., Sandeman, S., Howel, C., Liewen, L.: Polymeric hydrogels for novel contact lens–based ophthalmic drug delivery systems: a review. Contact Lens & Anterior Eye 31, 57–64 (2008)

    Article  Google Scholar 

Download references

Acknowledgements

This work was partially supported by the Centre for Mathematics of the University of Coimbra—UID/MAT/00324/2019, funded by the Portuguese Government through FCT/MEC and co-funded by the European Regional Development Fund through the Partnership Agreement PT2020.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to José Augusto Ferreira .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Ferreira, J.A. (2020). Drug Delivery from Ophthalmic Lenses. In: Lindner, E., Micheletti, A., Nunes, C. (eds) Mathematical Modelling in Real Life Problems. Mathematics in Industry(), vol 33. Springer, Cham. https://doi.org/10.1007/978-3-030-50388-8_5

Download citation

Publish with us

Policies and ethics