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Coordination of Fungal Secondary Metabolism and Development

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Genetics and Biotechnology

Part of the book series: The Mycota ((MYCOTA,volume 2))

Abstract

Fungi are ubiquitous lifeforms that colonize a wide range of diverse environments. Many of them have a saprophytic lifestyle and are principal decomposers of our ecosystem. Fungi play an important role in our food and pharmaceutical industries, but their appearance can also be harmful to us. They are responsible for many diseases in humans and animals, ranging from allergies to life-threatening intoxications and mycoses. The infection of plants and the contamination of crops lead to high economic losses and pose a threat to food supply and safety. Fungal developmental programs, including the formation of infection structures, are closely linked to the production of specific chemicals, called secondary metabolites. This chapter describes these interrelated processes and their regulation, including the genetic networks linking transcriptional to epigenetic control of gene expression, protein degradation machineries, and the autophagy membrane trafficking pathway.

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Notes

  1. 1.

    Ascus = skin bag.

  2. 2.

    Virulence = severity of a disease caused by a pathogen.

  3. 3.

    Pathogenicity = ability of a pathogen to cause a disease.

  4. 4.

    H3R4 = histone H4 modified at arginine residue 3 (R3).

  5. 5.

    H3K4Me3 = histone H3 trimethylated (Me3) at lysine residue 4 (K4).

  6. 6.

    lid = removable or hinged cover of a container, here: the cover of the proteasome core.

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Acknowledgments

We thank Fruzsina Bakti and Christoph Sasse for critical reading of the manuscript. Funding of this research was provided by the Deutsche Forschungsgemeinschaft (DFG) and the SFB860.

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Authors and Affiliations

  1. Institut für Mikrobiologie und Genetik, Abteilung Molekulare Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften (GZMB), Georg-August-Universität Göttingen, Göttingen, Germany

    Jennifer Gerke, Anna M. Köhler, Cindy Meister, Karl G. Thieme, Hugo Amoedo & Gerhard H. Braus

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  1. Jennifer Gerke
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  2. Anna M. Köhler
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  3. Cindy Meister
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  4. Karl G. Thieme
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  6. Gerhard H. Braus
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Correspondence to Gerhard H. Braus .

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  1. TUM School of Life Sciences Weihenstephan, Holzforschung München – Fungal Biotechnology in Wood Science, Technische Universität München, Freising, Germany

    J. Philipp Benz

  2. Institut für Mikrobiologie, Department Biologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany

    Kerstin Schipper

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Gerke, J., Köhler, A.M., Meister, C., Thieme, K.G., Amoedo, H., Braus, G.H. (2020). Coordination of Fungal Secondary Metabolism and Development. In: Benz, J.P., Schipper, K. (eds) Genetics and Biotechnology. The Mycota, vol 2. Springer, Cham. https://doi.org/10.1007/978-3-030-49924-2_8

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