Abstract
There are numerous situations where it is necessary to perform multiple tests in the confirmatory analysis of a clinical trial. Multiplicity may, for example, arise when multiple endpoints are defined as primary outcomes in a two-group trial, when more than two groups are to be compared, or when a combination of both occurs. This chapter presents various methods for sample size calculation in case of multiple comparisons. Different success criteria and related power concepts are considered. Sample size calculation methods which are generally applicable are presented. Furthermore, methods tailored to the assessment of multiple endpoints and to comparisons between more than two groups are given.
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Kieser, M. (2020). Multiple Comparisons. In: Methods and Applications of Sample Size Calculation and Recalculation in Clinical Trials. Springer Series in Pharmaceutical Statistics. Springer, Cham. https://doi.org/10.1007/978-3-030-49528-2_11
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DOI: https://doi.org/10.1007/978-3-030-49528-2_11
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Publisher Name: Springer, Cham
Print ISBN: 978-3-030-49527-5
Online ISBN: 978-3-030-49528-2
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