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Targeting the Immune System in Pancreatic Cancer

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Translational Pancreatic Cancer Research

Part of the book series: Molecular and Translational Medicine ((MOLEMED))

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Abstract

Pancreatic cancer has a very dismal prognosis, because of the late detection of the entity and the scarcity of therapeutic options. While chemotherapeutics are used for standard patient care, targeted therapeutic approaches so far did not add a considerable survival benefit. Mild- to absent response to standard or targeted therapies can be attributed to the genetic-epigenetic heterogeneity of the tumor in general. On the other hand, immunotherapeutic approaches hold  promise due to their potential to boost the anti-tumor immune response. Especially the adaptive immune system with its large antigen recognition repertoire can bypass an acquired genetic-epigenetic heterogeneity of tumors. However, although immunotherapy has demonstrated powerful impact on many tumor entities, its effect on pancreatic cancer is not yet convincing. The biggest obstacle for successful immunotherapy in pancreatic cancer appears to be its unique tumor microenvironment. Therefore, other than dissecting cancer cell-specific resistances, an understanding of the microenvironmental tumor immune network specifically in pancreatic cancer is required. Here in this chapter, upon an introduction to major immune cell types in the tumor microenvironment, we aim to reveal how pancreatic cancer circumvents the benefits of currently employed immunotherapeutic approaches and consider options for future improvements.

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Authors and Affiliations

  1. Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universitat München, Munich, Germany

    D. Kabacaoglu & Hana Algül

  2. Department of Surgery, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany

    D. A. Ruess

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  1. D. Kabacaoglu
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  2. D. A. Ruess
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Correspondence to Hana Algül .

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Editors and Affiliations

  1. Department of Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale), Halle (Saale), Sachsen-Anhalt, Germany

    Christoph W. Michalski

  2. Department of Internal Medicine I, University Hospital Halle (Saale), Halle (Saale), Sachsen-Anhalt, Germany

    Jonas Rosendahl

  3. Department of Internal Medicine I, University Hospital Halle (Saale), Halle (Saale), Sachsen-Anhalt, Germany

    Patrick Michl

  4. Department of Visceral, Vascular and Endocrine Surgery, University Hospital Halle (Saale), Halle (Saale), Sachsen-Anhalt, Germany

    Jörg Kleeff

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Kabacaoglu, D., Ruess, D.A., Algül, H. (2020). Targeting the Immune System in Pancreatic Cancer. In: Michalski, C., Rosendahl, J., Michl, P., Kleeff, J. (eds) Translational Pancreatic Cancer Research. Molecular and Translational Medicine. Humana, Cham. https://doi.org/10.1007/978-3-030-49476-6_14

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  • DOI: https://doi.org/10.1007/978-3-030-49476-6_14

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  • Publisher Name: Humana, Cham

  • Print ISBN: 978-3-030-49475-9

  • Online ISBN: 978-3-030-49476-6

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