Abstract
Synonym: Citrus × vulgaris Risso (Adams, 1972)
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Selected bibliography
Adams CD (1972) The flowering plants of Jamaica. Kingston: University of the West Indies, 848 pp.
Bisset NG, Wichtl M (1994) Herbal drugs and phytopharmaceuticals. Stuttgart: Medpharm Scientific Publishers.
Blumenthal M, Busse WR, Goldberg A, Gruenwald J, Hall T, Riggins CW, Rister RS (Eds.). Klein S, Rister RS (Trans.) (1998) The complete German Commission E Monographs: Therapeutic guide to herbal medicines. Austin, TX: American Botanical Council.
Blumenthal M (2004; 2005) Bitter orange peel and synephrine. Parts 1 & 2. American Botanical Council. Accessed 27 December 2019 at http://abc.herbalgram.org/site/DocServer/Bitter_Orange_Peel_and_Synephrine.pdf?docID=221.
Brinker F (2010) Herbal contraindications and drug interactions plus herbal adjuncts with medicines, expanded 4th edition. Sandy: Eclectic Medical Publications.
Bui LT, Nguyen DT, Ambrose PJ (2006) Blood pressure and heart rate effects following a single dose of bitter orange. The Annals of Pharmacotherapy 40: 53-57.
Colker CM, Kaiman DS, Torina GC, Perlis T, Street C (1999) Effects of Citrus aurantium extract, caffeine, and St. John’s Wort on body fat loss, lipid levels, and mood states in overweight healthy adults. Current Therapeutic Research 60: 145-153.
Delgoda R, Picking D (2015) Potential drug interactions for commonly used medicinal plants & foods in Jamaica. Kingston: University of the West Indies, Natural Products Institute.
Deshmukh NS, Stohs SH, Magar CC, Kale A, Sowmya B (2017). Bitter orange (Citrus aurantium L.) extract subchronic 90-day safety study in rats. Toxicology Reports 4: 598-613.
Dharmananda S (n.d.) Synephrine: Is Chih-shih (Zhishi) toxic? Accessed 27 December 2019 at http://www.itmonline.org/arts/syneph.htm.
Di Marco MP, Edwards DJ, Wainer IW, Ducharme MP (2002) The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: The role of gut CYP3A and P-glycoprotein. Life Sciences 71: 1149-1160.
Edwards DJ, Fitzsimmons ME, Schuetz EG, Yasuda K, Ducharme MP, Warbasse LH, Woster PM, Schuetz JD, Watkins P (1999) 6’,7’-dihydroxybergamottin in grapefruit juice and seville orange juice: Effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein. Clinical Pharmacology and Therapeutics 65: 237-244.
Farshbaf-Khalili A, Kamalifard M, Namadian M (2018) Comparison of the effect of lavender and bitter orange on anxiety in postmenopausal women: A triple-blind, randomized, controlled clinical trial. Complementary Therapies in Clinical Practice 31: 132-138.
Fugh-Berman A, Myers A (2004) Citrus aurantium, an ingredient of dietary supplements marketed for weight loss: Current status of clinical and basic research. Experimental Biology and Medicine 229: 698-704.
Germosén-Robineau L (2014) Farmacopea vegetal Caribeña. Tercera Edición. Yucatán, Mexico: Centro de Investigación Científica de Yucatán.
Guo LQ, Taniguchi M, Chen QY, Baba K, Yamazoe Y (2001) Inhibitory potential of herbal medicines on human cytochrome P450-mediated oxidation: Properties of umbelliferous or citrus crude drugs and their relative prescriptions. Japanese Journal of Pharmacology 85: 399-408.
Gurley BJ, Gardner SF, Hubbard MA, Williams DK, Gentry WB, Carrier J, Khan IA, Edwards DJ, Shah A (2004) In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto. Clinical Pharmacology and Therapeutics 76: 428-440.
Haaz S, Fontaine KR, Cutter G, Limdi N, Perumean-Chaney S, Allison DB (2006) Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update. Obesity Reviews 7: 79-88.
Kamalifard M, Farshbaf-Khalili A, Namadian M, Ranjbar Y, Herizchi S (2018) Comparison of the effect of lavender and bitter orange on sleep quality in postmenopausal women: A triple-blind, randomized, controlled clinical trial. Women & Health 58: 851-865.
Leung AY, Foster S (1996) Encyclopedia of natural ingredients used in foods, drugs, and cosmetics. New York: John Wiley.
Lin SP, Wu PP, Hou YC, Tsai SY, Wang MJ, Fang SH, Chao PD (2011) Different influences on tacrolimus pharmacokinetics by coadministrations of zhi ke and zhi shi in rats. Evidence-Based Complementary and Alternative Medicine, Article ID 751671, 6 pages. Accessed 27 December 2019 at https://www.hindawi.com/journals/ecam/2011/751671/.
Lüde S, Vecchio S, Sinno-Tellier S, Dopter A, Mustonen H, Vucinic S, Jonsson B, Müller D, Veras Gimenez Fruchtengarten L, Hruby K, De Souza Nascimento E, Di Lorenzo C, Restani P, Kupferschmidt H, Ceschi A (2016) Adverse effects of plant food supplements and plants consumed as food: Results from the poisons centres-based PlantLIBRA Study. Phytotherapy Research 30: 988-996.
Malhotra S, Bailey DG, Paine MF, Watkins PB (2001) Seville orange juice-felodipine interaction: Comparison with diluted grapefruit juice and involvement of furocoumarins. Clinical Pharmacology and Therapeutics 69: 14-23.
Morton J (1987) Sour orange. In: Fruits of warm climates. Miami, Florida: Julia F. Morton. Pp. 130-133.
Morton J (2013) Fruits of warm climates. Brattleboro: Echo Point Books and Media.
Natural Medicines (2007) Formerly Natural Standard and Natural Medicines Comprehensive Database. Citrus aurantium. Accessed 31 December 2007 at https://naturalmedicines.therapeuticresearch.com/.
Paul A, Cox PA (1995) An ethnobotanical survey of the uses for Citrus aurantium (Rutaceae) in Haiti. Economic Botany 49: 249-256.
Penzak SR, Acosta EP, Turner M, Edwards DJ, Hon YY, Desai HD, Jann MW (2002) Effect of seville orange juice and grapefruit juice on indinavir pharmacokinetics. Journal of Clinical Pharmacology 42: 1165-1170.
Restani P, Di Lorenzo C, Garcia-Alvarez A, Badea, M, Ceschi A, Egan B, Serra-Majem L (2016) Adverse effects of plant food supplements self-reported by consumers in the PlantLIBRA Survey involving six European countries. PLoS One 11: e0150089.
Seifert JG, Nelson A, Devonish J, Burke ER, Stohs S J (2011) Effect of acute administration of an herbal preparation on blood pressure and heart rate in humans. International Journal of Medical Sciences 8: 192-197.
Stohs SJ, Shara M (2007) A review of the safety and efficacy of Citrus aurantium in weight management. In Obesity: Epidemiology, pathophysiology, and prevention. Bagchi D, Preuss HG (Eds). Boca Raton: CRC Press.
Stohs SJ (2010) A review and assessment of the FDA adverse events reports and clinical case reports between April 2004 and October 2009. Journal of Functional Foods 2: 235–238.
Stohs SJ, Preuss HG (2010) The safety of bitter orange (Citrus aurantium) and p-synephrine. HerbalGram 89: 34-39.
Stohs SJ, Preuss HG, Shara M (2011) The safety of Citrus aurantium (bitter orange) and its primary protoalkaloid p-synephrine. Phytotherapy Research 25: 1421-1428.
Stohs SJ, Preuss HG, Shara M (2012) A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine. International Journal of Medical Sciences 9: 527-538.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2020 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Vandebroek, I., Picking, D. (2020). Citrus × aurantium L. (Rutaceae). In: Popular Medicinal Plants in Portland and Kingston, Jamaica. Advances in Economic Botany. Springer, Cham. https://doi.org/10.1007/978-3-030-48927-4_9
Download citation
DOI: https://doi.org/10.1007/978-3-030-48927-4_9
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-48926-7
Online ISBN: 978-3-030-48927-4
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)