Advertisement

Health Promoting Activities of Nigella sativa Seed Extracts

Chapter
  • 290 Downloads
Part of the Food Bioactive Ingredients book series (FBC)

Abstract

Many medical plant have recently attracted attention due to their important role as dietary supplements with health-promotive effects amd minimal side impacts. Nigella sativa, also known as black seed, belongs to Ranunculaceae family is cultivated in various areas of the world mostly in Middle Eastern, Far Eastern, Asian and East Mediterranean countries. Valuable seeds, extracts and oils of Nigella sativa, which contain vitamins, minerals, essential fatty acids and many other useful components, have been used since ancient times. Today, Nigella sativa seeds and seed extracts have been used for healing several disorders due to their antioxidant properties. Studies have shown that Nigella sativa is very effective in terms of health promotion and disease prevention. Nigella sativa seeds have useful effects such as neuroprotective, antihypertensive, anticancer, antidiabetic, anti-inflammatory, analgesic, antibacterial, antifungal, antiviral and antiparasitic activities. Nigella sativa seed extracts might be a potential new health promotive agent due to the proven beneficial activities. Nigella sativa seed extracts might be used as essential nutrients sources or as a nutritional supplement. This chapter provide detailed information about the botanical properties of Nigella sativa, functionalities of phytochemicals, therapeutic effects of Nigella sativa extracts, protective effects against certain diseases to reveal the potential of the use of Nigella sativa seed extracts and to shed light on the future Nigella sativa-related studies.

Keywords

Pharmacological Antimicrobial Anti-inflammatory Respiratory Neuroprotective 

Abbreviations

EO

Essential oil

IDF

International Diabetes Federation

MBC

Minimal bactericidal concentration

MIC

Minimum inhibitory concentration

TQ

Thymoquinone

WHO

World Health Organization

References

  1. Abbasnezhad, A., Hayatdavoudi, P., Niazmand, S., & Mahmoudabady, M. (2015). The effects of hydroalcoholic extract of Nigella sativa seed on oxidative stress in hippocampus of STZ-induced diabetic rats. Avicenna Journal of Phytomedicine, 5(4), 333–340.PubMedPubMedCentralGoogle Scholar
  2. Abbasnezhad, A., Niazmand, S., Mahmoudabady, M., Soukhtanloo, M., Rezaee, S. A., & Mousavi, S. M. (2016). Nigella sativa seed decreases endothelial dysfunction in streptozotocin-induced diabetic rat aorta. Avicenna Journal of Phytomedicine, 6(1), 67–76.PubMedPubMedCentralGoogle Scholar
  3. Abbasnezhad, A., Niazmand, S., Mahmoudabady, M., Rezaee, S. A., Soukhtanloo, M., Mosallanejad, R., & Hayatdavoudi, P. (2019). Nigella sativa L. seed regulated eNOS, VCAM-1 and LOX-1 genes expression and improved vasoreactivity in aorta of diabetic rat. Journal of Ethnopharmacology, 228, 142–147.  https://doi.org/10.1016/j.jep.2018.09.021.CrossRefPubMedPubMedCentralGoogle Scholar
  4. Ahmed, J. H., Ibraheem, A. Y., & Al-Hamdi, K. I. (2015). Evaluation of efficacy, safety and antioxidant effect of Nigella sativa in patients with psoriasis: A randomized clinical trial. Journal of Clinical and Experimental Investigations, 5(2), 186–193.Google Scholar
  5. Akhtar, M. S., & Riffat, S. (1991). Field trial of Saussurea lappa roots against nematodes and Nigella sativa seeds against cestodes in children. The Journal of the Pakistan Medical Association, 41, 185–187.PubMedPubMedCentralGoogle Scholar
  6. Alimohammadi, S., Hobbenaghi, R., Javanbakht, J., Kheradmand, D., Mortezaee, R., Tavakoli, M., Khadivar, F., & Akbari, H. (2013). Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced diabetic in rats: An experimental study with histopathological evaluation. Diagnostic Pathology, 8(137), 1–7.Google Scholar
  7. Aljabre, S. H. M., Randhawa, M. A., Akhtar, N., Alakloby, O. M., Alqurashi, A. M., & Aldossary, A. (2005). Antidermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone. Journal of Ethnopharmacology, 101(1–3), 116–119.PubMedCrossRefPubMedCentralGoogle Scholar
  8. Al-Naggar, T. B., Gómez-Serranillos, M. P., Carretero, M. E., & Villar, A. M. (2003). Neuropharmacological activity of Nigella sativa L. extracts. Journal of Ethnopharmacology, 88(1), 63–68.PubMedCrossRefPubMedCentralGoogle Scholar
  9. Al-Naggar, R. A., Osman, M. T., Mohamed, I. N., Aripin, K. N. B. N., & Abdulghani, M. A. M. (2017). Effect of Nigella sativa supplementation on human lipids: Systematic review. Journal of Applied Pharmaceutical Science, 7(4), 213–219.Google Scholar
  10. Arafa, N. M. S., Abdel-Rahman, M., El-Khadragy, M. F., & Kassab, R. B. (2013). Evaluation of the possible epileptogenic activity of ciprofloxacin: The role of Nigella sativa on amino acids neurotransmitters. Neurochemical Research, 38(1), 174–185.PubMedCrossRefPubMedCentralGoogle Scholar
  11. Asaduzzaman, M., Nahar, L., Rahman, M. S., Hasan, M., Khatun, A., et al. (2015). Hypoglycemic and hypolipidemic potential of Nigella sativa L. seed extract in streptozotocin (STZ)-induced diabetic rats. Journal of Plant Biochemistry & Physiology, 3(4), 1–5.Google Scholar
  12. Asiaei, F., Fazel, A., Rajabzadeh, A. A., Hosseini, M., Beheshti, F., & Seghatoleslam, M. (2017). Neuroprotective effects of Nigella sativa extract upon the hippocampus in PTU-induced hypothyroidism juvenile rats: A stereological study. Metabolic Brain Disease, 32(5), 1755–1765.PubMedCrossRefPubMedCentralGoogle Scholar
  13. Beheshti, F., Hosseini, M., Shafei, M. N., Soukhtanloo, M., Ghasemi, S., Vafaee, F., & Zarepoor, L. (2014). The effects of Nigella sativa extract on hypothyroidism-associated learning and memory impairment during neonatal and juvenile growth in rats. Nutritional Neuroscience, 0(0), 1–11.Google Scholar
  14. Beheshti, F., Hosseini, M., Shafei, M. N., Soukhtanloo, M., Ghasemi, S., Vafaee, F., & Zarepoor, L. (2017). The effects of Nigella sativa extract on hypothyroidism-associated learning and memory impairment during neonatal and juvenile growth in rats. Nutritional Neuroscience, 20(1), 49–59.  https://doi.org/10.1179/1476830514y.0000000144.CrossRefPubMedPubMedCentralGoogle Scholar
  15. Bhandari, P. (2014). Potential role of Nigella sativa (black cumin) in epilepsy. International Journal of Nutrition, Pharmacology, Neurological Diseases, 4(3), 188.CrossRefGoogle Scholar
  16. Bita, A., Rosu, A. F., Calina, D., Rosu, L., Zlatian, O., Dindere, C., & Simionescu, A. (2012). An alternative treatment for Candida infections with Nigella sativa extracts. European Journal of Hospital Pharmacy, 19(2), 162.2–162.CrossRefGoogle Scholar
  17. Boskabady, M. H., & Farhadi, J. (2008). The possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims: A randomized, double-blind, placebo-controlled trial. Journal of Alternative and Complementary Medicine, 14(9), 1137–1144.PubMedCrossRefPubMedCentralGoogle Scholar
  18. Boskabady, M., Shafei, M., & Parsaee, H. (2005). Effects of aqueous and macerated extracts from Nigella sativa on guinea pig isolated heart activity. Die Pharmazie – An International Journal of Pharmaceutical Sciences, 60, 943–948.Google Scholar
  19. Boskabady, M. H., Keyhanmanesh, R., Khameneh, S., Doostdar, Y., & Khakzad, M. R. (2011a). Potential immunomodulation effect of the extract of Nigella sativa on ovalbumin sensitized guinea pigs. Journal of Zhejiang University: Science B, 12(3), 201–209.PubMedCrossRefPubMedCentralGoogle Scholar
  20. Boskabady, M. H., Keyhanmanesh, R., Khamneh, S., & Ebrahimi, M. A. (2011b). The effect of Nigella sativa extract on tracheal responsiveness and lung inflammation in valbuminsensitized guinea pigs. Clinics, 66(5), 879–887.PubMedPubMedCentralCrossRefGoogle Scholar
  21. Bourgou, S., Pıchette, A., Marzouk, B., & Legault, J. (2012). Antioxidant, anti-inflammatory, anticancer and antibacterial activities of extracts from Nigella Sativa (black cumin) plant parts. Journal of Food Biochemistry, 36(5), 539–546.  https://doi.org/10.1111/j.1745-4514.2011.00567.x.CrossRefGoogle Scholar
  22. Butt, U. J., Shah, S. A. A., Ahmed, T., & Zahid, S. (2018). Protective effects of Nigella sativa L. seed extract on lead induced neurotoxicity during development and early life in mouse models. Toxicology Research, 7(1), 32–40.PubMedCrossRefGoogle Scholar
  23. Çelik Altunoğlu, Y., Bilen, S., Ulu, F., & Biswas, G. (2017). Immune responses to methanolic extract of black cumin (Nigella sativa) in rainbow trout (Oncorhynchus mykiss). Fish and Shellfish Immunology, 67, 103–109.PubMedCrossRefGoogle Scholar
  24. Chehl, N., Chipitsyna, G., Gong, Q., Yeo, C. J., & Arafat, H. A. (2009). Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells. HPB, 11(5), 373–381.PubMedPubMedCentralCrossRefGoogle Scholar
  25. Dehkordi, F. R., & Kamkhah, A. F. (2008). Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundamental & Clinical Pharmacology, 22(4), 447–452.  https://doi.org/10.1111/j.1472-8206.2008.00607.x.CrossRefGoogle Scholar
  26. Dilshad, A., Abulkhair, O., Nemenqani, D., & Tamimi, W. (2012). Antiproliferative properties of methanolic extract of Nigella sativa against the MDA-MB-231 cancer cell line. Asian Pacific Journal of Cancer Prevention, 13(11), 5839–5842.PubMedCrossRefGoogle Scholar
  27. Dirjomuljono, M., Kristyono, I., Tjandrawinata, R. R., & Nofiarny, D. (2008). Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract. International Journal of Clinical Pharmacology and Therapeutics, 46(6), 295–306.PubMedCrossRefGoogle Scholar
  28. El Rabey, H. A., Al-Seeni, M. N., & Bakhashwain, A. S. (2017). The Antidiabetic activity of Nigella sativa and propolis on streptozotocin-induced diabetes and diabetic nephropathy in male rats. Evidence-Based Complementary and Alternative Medicine : ECAM, 2017, 5439645.  https://doi.org/10.1155/2017/5439645.CrossRefGoogle Scholar
  29. El-Naggar, T., Gómez-Serranillos, M. P., Palomino, O. M., Arce, C., & Carretero, M. E. (2010). Nigella sativa L. seed extract modulates the neurotransmitter amino acids release in cultured neurons in vitro. Journal of Biomedicine and Biotechnology, 2010.Google Scholar
  30. El-Naggar, T., Carretero, M. E., Arce, C., & Gómez-Serranillos, M. P. (2017). Methanol extract of Nigella sativa seed induces changes in the levels of neurotransmitter amino acids in male rat brain regions. Pharmaceutical Biology, 55(1), 1415–1422.PubMedPubMedCentralCrossRefGoogle Scholar
  31. Enayatfard, L., Mohebbati, R., Niazmand, S., Hosseini, M., & Shafei, M. N. (2019). The standardized extract of Nigella sativa and its major ingredient, thymoquinone, ameliorates angiotensin II-induced hypertension in rats. Journal of Basic and Clinical Physiology and Pharmacology, 30(1), 51–58.CrossRefGoogle Scholar
  32. Ghannadi, A., Hajhashemi, V., & Jafarabadi, H. (2005). An investigation of the analgesic and anti-inflammatory effects of Nigella sativa seed polyphenols. Journal of Medicinal Food, 8(4), 488–493.PubMedCrossRefPubMedCentralGoogle Scholar
  33. Haas, M. J., Onstead-Haas, L., Naem, E., Arnold, A., Rohrbaugh, N., Flowers, M., & Mooradian, A. D. (2014). The effect of black seed (Nigella sativa) extract on FOXO3 expression in HepG2 cells. Phytotherapy Research, 28(6), 873–879.PubMedCrossRefPubMedCentralGoogle Scholar
  34. Hadjzadeh, M. A. R., Khoei, A., Hadjzadeh, Z., & Parizady, M. (2007). Ethanolic extract of Nigella sativa L. seeds on ethylene glycol-induced kidney calculi in rats. Urology Journal, 4(2), 86–90.PubMedPubMedCentralGoogle Scholar
  35. Hannan, A., Saleem, S., Chaudhary, S., Barkaat, M., & Arshad, M. U. (2008). Anti bacterial activity of Nigella sativa against clinical isolates of methicillin resistant Staphylococcus aureus. Journal of Ayub Medical College, Abbottabad : JAMC, 20(3), 72–74.PubMedPubMedCentralGoogle Scholar
  36. Hasan, N. A., Nawahwi, M. Z., & Malek, H. A. (2013). Antimicrobial activity of Nigella sativa seed extract. Sains Malaysiana, 42(2), 143–147.Google Scholar
  37. Hebi, M., Zeggwagh, N., Hajj, L., El Bouhali, B., & Eddouks, M. (2016). Cardiovascular effect of Nigella sativa L. aqueous extract in normal rats. Cardiovascular & Haematological Disorders- Drug Targets., 16(1), 47–55(9).CrossRefGoogle Scholar
  38. Hosseini, M., Mohammadpour, T., Karami, R., Rajaei, Z., Reza Sadeghnia, H., & Soukhtanloo, M. (2015). Effects of the hydro-alcoholic extract of Nigella sativa on scopolamine-induced spatial memory impairment in rats and its possible mechanism. Chinese Journal of Integrative Medicine, 21(6), 438–444.PubMedCrossRefPubMedCentralGoogle Scholar
  39. Hosseinzadeh, H., Fazly Bazzaz, B. S., & Haghi, M. M. (2007). Antibacterial activity of total extracts and essential oil of Nigella sativa L. seeds in mice. Pharmacology, 2, 429–435.Google Scholar
  40. Ikhsan, M., Hiedayati, N., Maeyama, K., & Nurwidya, F. (2018). Nigella sativa as an anti-inflammatory agent in asthma. BMC Research Notes, 11(1), 1–5.CrossRefGoogle Scholar
  41. Kumara, S. S. M., & Kwong Huat, B. T. (2001). Extraction, isolation and characterisation of antitumor principle, αhederin, from the seeds of Nigella sativa. Planta Medica, 67(1), 29–32.PubMedCrossRefPubMedCentralGoogle Scholar
  42. Le, P. M., Benhaddou-Andaloussi, A., Elimadi, A., Settaf, A., Cherrah, Y., & Haddad, P. S. (2004). The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat. Journal of Ethnopharmacology, 94, 251–259.PubMedCrossRefPubMedCentralGoogle Scholar
  43. Mbarek, L. A., Mouse, H. A., Elabbadi, N., Bensalah, M., Gamouh, A., Aboufatima, R., Benharref, A., Chait, A., Kamal, M., Dalal, A., & Zyad, A. (2007). Anti-tumor properties of blackseed (Nigella sativa L.) extracts. Brazilian Journal of Medical and Biological Research, 40(6), 839–847.CrossRefGoogle Scholar
  44. Meziti, A., Meziti, H., Boudiaf, K., & Benboubetra, M. H. B. (2012). Polyphenolic profile and antioxidant activities of Nigella sativa seed extracts in vitro and in vivo. World Academy of Science, 6(4), 26–32.Google Scholar
  45. Mohebbati, R., Shafei, M. N., Soukhtanloo, M., Mohammadian Roshan, N., Khajavi Rad, A., Anaeigoudari, A., Hosseinian, S., Karimi, S., & Beheshti, F. (2016). Adriamycin-induced oxidative stress is prevented by mixed hydro-alcoholic extract of Nigella sativa and Curcuma longa in rat kidney. Avicenna Journal of Phytomedicine, 6(1), 86–94.PubMedPubMedCentralGoogle Scholar
  46. Mohebbati, R., Shafei, M. N., Beheshti, F., Soukhtanloo, M., Roshan, N. M., Anaeigoudari, A., Parhizgar, S., Hosseinian, S., Khazdeir, M. R., & Rad, A. K. (2017a). Mixed hydroalcoholic extracts of Nigella sativa and Curcuma longa improves adriamycin-induced renal injury in rat. Saudi Journal of Kidney Diseases and Transplantation: An Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 28(6), 1270–1281.CrossRefGoogle Scholar
  47. Mohebbati, R., Hosseini, M., Haghshenas, M., Nazariborun, A., & Beheshti, F. (2017b). The effects of Nigella sativa extract on renal tissue oxidative damage during neonatal and juvenile growth in propylthiouracil-induced hypothyroid rats. Endocrine Regulations, 51(2), 105–113.PubMedCrossRefPubMedCentralGoogle Scholar
  48. Nehar, S., Kauser, H., Rani, P., & Alam, I. (2015). Effects of Nigella sativa seed extract on insulin resistant non-insulin-dependent diabetic guinea pigs. American Journal of Ethnomedicine, 2(1), 58–67.Google Scholar
  49. Niazmand, S., Fereidouni, E., Mahmoudabady, M., & Mousavi, S. M. (2014). Endothelium-independent vasorelaxant effects of hydroalcoholic extract from Nigella sativa seed in rat aorta: The roles of Ca2+ and K+ channels. BioMed Research International, 2014.Google Scholar
  50. Okeola, V. O., Adaramoye, O. A., Nneji, C. M., Falade, C. O., Farombi, E. O., & Ademowo, O. G. (2011). Antimalarial and antioxidant activities of methanolic extract of Nigella sativa seeds (black cumin) in mice infected with Plasmodium yoelli nigeriensis. Parasitology Research, 108, 1507–1512.PubMedCrossRefGoogle Scholar
  51. Pranav, C. (2018). Effect of Nigella sativa seed extract on lipid and protein oxidation in raw ground pork during refrigerated storage. Nutrition & Food Science, 48(1), 2–15.  https://doi.org/10.1108/NFS-02-2017-0031.CrossRefGoogle Scholar
  52. Rizka, A., Setiati, S., Lydia, A., & Dewiasty, E. (2017). Effect of Nigella sativa seed extract for hypertension in elderly: A double-blind, randomized controlled trial. Acta Medica Indonesiana, 49(4), 307–313.PubMedGoogle Scholar
  53. Sen, A., Choudhuri, P., & Chatterjee, R. (2018). Influence of inorganic nutrient, organic nutrient and bio-fertilizer on growth, yield and quality of cumin black (Nigella sativa L.) in eastern Himalayan region of West Bengal. Journal of Pharmacognosy and Phytochemistry, 7(2), 2571–2575.Google Scholar
  54. Shin, M.-S., Ko, I.-G., Kim, S.-E., Kim, B.-K., Kim, T.-S., Lee, S.-H., et al. (2013). Treadmill exercise ameliorates symptoms of methimazole-induced hypothyroidism through enhancing neurogenesis and suppressing apoptosis in the hippocampus of rat pups. International Journal of Developmental Neuroscience, 31(3), 214–223.PubMedCrossRefPubMedCentralGoogle Scholar
  55. Swamy, S. M. K., & Tan, B. K. H. (2001). Extraction, isolation and characterization of anti-tumor principle, alpha-Hederin, from the seeds of Nigella sativa. Planta Medica, 67, 29–32.CrossRefGoogle Scholar
  56. Tubesha, Z., Iqbal, S., & Ismail, M. (2011). Effects of hydrolysis conditions on recovery of antioxidants from methanolic extracts of Nigella sativa seeds. Journal of Medicinal Plant Research, 5(22), 5393–5399.Google Scholar
  57. Wagner, M. S., Wajner, S. M., & Maia, A. L. (2008). Theroleofthyroidhormonein testicular development and function. Journal Endocrinology, 199(3), 351–365.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2021

Authors and Affiliations

  1. 1.Department of Food Engineering, Faculty of EngineeringSuleyman Demirel UniversityIspartaTurkey

Personalised recommendations