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Tumor Microenvironment pp 1–16Cite as

Elastin in the Tumor Microenvironment

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 1272)

Abstract

Elastic fibers are found in the extracellular matrix (ECM) of tissues requiring resilience and depend on elasticity. Elastin and its degradation products have multiple roles in the oncologic process. In many malignancies, the remodeled ECM expresses high levels of the elastin protein which may have either positive or negative effects on tumor growth. Elastin cross-linking with other ECM components and the enzymes governing this process all have effects on tumorigenesis. Elastases, and specifically neutrophil elastase, are key drivers of invasion and metastasis and therefore are important targets for inhibition. Elastin degradation leads to the generation of bioactive fragments and elastin-derived peptides that further modulate tumor growth and spread. Interestingly, elastin-like peptides (ELP) and elastin-derived peptides (EDP) may also be utilized as nano-carriers to combat tumor growth. EDPs drive tumor development in a variety of ways, and specifically targeting EDPs and their binding proteins are major objectives for ongoing and future anti-cancer therapies. Research on both the direct anti-cancer activity and the drug delivery capabilities of ELPs is another area likely to result in novel therapeutic agents in the near future.

Keywords

  • Elastin
  • Elastic fiber
  • Elastin-binding protein
  • Elastosis
  • Elastoma
  • Extracellular matrix
  • Elastase
  • Neutrophil elastase
  • Elastin-like peptide
  • Elastin-derived peptide
  • Elastin receptor
  • Tumor-associated stroma
  • Lysyl oxidases
  • Elastin collagen cross-linking
  • Tumor microenvironment

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Fig. 1.1
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Fig. 1.3
Fig. 1.4

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Rhode Island Hospital and Lifespan Medical Center, Warren Alpert Medical School of Brown University, Providence, RI, USA

    Yihong Wang & Murray B. Resnick

  2. Brown University, Providence, RI, USA

    Elizabeth C. Song

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  1. Yihong Wang
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  2. Elizabeth C. Song
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  3. Murray B. Resnick
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Correspondence to Yihong Wang .

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Editors and Affiliations

  1. Department of Radiology, Columbia University Medical Center, New York, NY, USA, Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Dr. Alexander Birbrair

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Wang, Y., Song, E.C., Resnick, M.B. (2020). Elastin in the Tumor Microenvironment. In: Birbrair, A. (eds) Tumor Microenvironment . Advances in Experimental Medicine and Biology, vol 1272. Springer, Cham. https://doi.org/10.1007/978-3-030-48457-6_1

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