Abstract
Infectious endocarditis, though relatively infrequent, remains a life-threatening infection that occurs across the spectrum of patient age, race, and sex. Some physical findings are classic, though most diagnoses are made in the setting of high clinical suspicion prompting blood cultures and echocardiography. Common pathogens causing infective endocarditis include S. aureus, streptococci, coagulase-negative staphylococci, and gram-negative bacilli (including the HACEK organisms). Empiric antibiotic therapy for infective endocarditis should begin only after blood cultures are drawn to ensure that the causative organism can be identified and subsequently targeted for treatment. Approximately 50% of all patients with infective endocarditis may require some form of surgical intervention.
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References
Duval X, Delahaye F, Alla F, Tattevin P, Obadia JF, Le Moing V, Doco-Lecompte T, Celard M, Poyart C, Strady C, Chirouze C, Bes M, Cambau E, Iung B, Selton-Suty C, Hoen B, AEPEI Study Group. Temporal trends in infective endocarditis in the context of prophylaxis guideline modifications: three successive population-based surveys. J Am Coll Cardiol. 2012;59:1968–76. https://doi.org/10.1016/j.jacc.2012.02.029.
Fowler VG Jr, Sanders LL, Kong LK, McClelland RS, Gottlieb GS, Li J, Ryan T, Sexton DJ, Roussakis G, Harrell LJ, Corey GR. Infective endocarditis due to S. aureus: 59 prospectively identified cases with follow-up. Clin Infect Dis. 1999;28:106–14. https://doi.org/10.1086/515076.
Baddour LM, Wilson WR, Bayer AS, et al. Infective endocarditis in adults: diagnosis, antimicrobial therapy, and management of complications: a scientific statement for healthcare professionals from the American Heart Association. Circulation. 2015;132(15):1435–86.
Werner M, Andersson R, Olaison L, Hogevik H. A clinical study of culture-negative endocarditis. Medicine (Baltimore). 2003;82:263–73. https://doi.org/10.1097/01.md.0000085056.63483.d2.
Hoen B, Selton-Suty C, Lacassin F, Etienne J, Briançon S, Leport C, Canton P. Infective endocarditis in patients with negative blood cultures: analysis of 88 cases from a one-year nationwide survey in France. Clin Infect Dis. 1995;20:501–6.
Pazin GJ, Saul S, Thompson ME. Blood culture positivity: suppression by outpatient antibiotic therapy in patients with bacterial endocarditis. Arch Intern Med. 1982;142:263–8.
Andrews MM, von Reyn CF. Patient selection criteria and management guidelines for outpatient parenteral antibiotic therapy for native valve infective endocarditis. Clin Infect Dis. 33:203–9. https://doi.org/10.1086/321814.
Durack DT, Beeson PB. Experimental bacterial endocarditis, II: survival of a bacteria in endocardial vegetations. Br J Exp Pathol. 1972;53:50–3.
Dworkin RJ, Lee BL, Sande MA, Chambers HF. Treatment of right-sided S. aureus endocarditis in intravenous drug users with ciprofloxacin and rifampicin. Lancet. 1989;2:1071–3.
Lefort A, Mainardi JL, Selton-Suty C, Casassus P, Guillevin L, Lortholary O. Streptococcus pneumoniae endocarditis in adults: a multicenter study in France in the era of penicillin resistance (1991-1998): the Pneumococcal Endocarditis Study Group. Medicine (Baltimore). 2000;79:327–37.
Geraci JE, Wilson WR. Symposium on infective endocarditis, III: endocarditis due to Gram-negative bacteria: report of 56 cases. Mayo Clin Proc. 1982;57:145–8.
Sanfilippo AJ, Picard MH, Newell JB, Rosas E, Davidoff R, Thomas JD, Weyman AE. Echocardiographic assessment of patients with infectious endocarditis: prediction of risk for complications. J Am Coll Cardiol. 1991;18:1191–9.
Heiro M, Nikoskelainen J, Engblom E, Kotilainen E, Marttila R, Kotilainen P. Neurologic manifestations of infective endocarditis: a 17-year experience in a teaching hospital in Finland. Arch Intern Med. 2000;160:2781–7.
Steckelberg JM, Murphy JG, Ballard D, Bailey K, Tajik AJ, Taliercio CP, Giuliani ER, Wilson WR. Emboli in infective endocarditis: the prognostic value of echocardiography. Ann Intern Med. 1991;114:635–40. https://doi.org/10.7326/0003-4819-114-8-635.
Hess A, Klein I, Iung B, et al. Brain MRI findings in neurologically asymptomatic patients with infective endocarditis. AJNR Am J Neuroradiol. 2013;34:1579–84.
Carpenter JL. Perivalvular extension of infection in patients with infectious endocarditis. Rev Infect Dis. 1991;13:127–38.
Blumberg EA, Karalis DA, Chandrasekaran K, Wahl JM, Vilaro J, Covalesky VA, Mintz GS. Endocarditis-associated paravalvular abscesses: do clinical parameters predict the presence of abscess? Chest. 1995;107:898–903.
Daniel WG, Mügge A, Martin RP, Lindert O, Hausmann D, Nonnast-Daniel B, Laas J, Lichtlen PR. Improvement in the diagnosis of abscesses associated with endocarditis by transesophageal echocardiography. N Engl J Med. 1991;324:795–800. https://doi.org/10.1056/NEJM199103213241203.
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Ricketts, J., Jacob, J.T. (2020). Infective Endocarditis. In: Wells, B., Quintero, P., Southmayd, G. (eds) Handbook of Inpatient Cardiology. Springer, Cham. https://doi.org/10.1007/978-3-030-47868-1_15
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