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Physiology of Blood Pump Circulation in Heart Failure

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Mechanical Support for Heart Failure

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Abstract

In the current era of mechanical circulatory support, blood pumps play a crucial role in providing hemodynamic support in patients with end-stage chronic heart failure, and their use is expected to increase with the development of newer and better pumps. Optimal use of LVADs can facilitate LV unloading and reverse remodeling of the native heart. LVAD optimization, however, requires a comprehensive understanding of the physiology ventricular mechanics, the hemodynamics of blood pumps, and the interaction between the VAD, native ventricle, and the circulation. Knowledge of pump physiology is also vital for early identification and prevention of catastrophic conditions such as pump thrombosis and RV failure. In this chapter, we present a comprehensive clinically relevant review of the physiology of LVADs as applied to patients with chronic heart failure.

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Authors and Affiliations

  1. Maimonides Medical Center, Brooklyn, NY, USA

    Abhinav Saxena MBBS

  2. Columbia and Cornell Universities, New York Presbyterian, New York, NY, USA

    Nir Uriel MD

  3. Cardiovascular Research Foundation, New York, NY, USA

    Daniel Burkhoff MD, PhD

Authors
  1. Abhinav Saxena MBBS
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  2. Nir Uriel MD
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  3. Daniel Burkhoff MD, PhD
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Corresponding author

Correspondence to Daniel Burkhoff MD, PhD .

Editor information

Editors and Affiliations

  1. Lerner Research Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Cleveland Clinic, Cleveland, OH, USA

    Jamshid H. Karimov

  2. Lerner Research Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Cleveland Clinic, Cleveland, OH, USA

    Kiyotaka Fukamachi

  3. Kaufman Center for Heart Failure Heart, Thoracic, and Vascular Institute, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Cleveland Clinic, Cleveland, OH, USA

    Randall C. Starling

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Saxena, A., Uriel, N., Burkhoff, D. (2020). Physiology of Blood Pump Circulation in Heart Failure. In: Karimov, J., Fukamachi, K., Starling, R. (eds) Mechanical Support for Heart Failure . Springer, Cham. https://doi.org/10.1007/978-3-030-47809-4_5

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  • DOI: https://doi.org/10.1007/978-3-030-47809-4_5

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