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Measurement of Oxidative Stress Status in Human Populations: A Critical Need for a Metabolomic Profiling

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Measuring Oxidants and Oxidative Stress in Biological Systems

Part of the book series: Biological Magnetic Resonance ((BIMR,volume 34))

Abstract

Oxidative stress (OS) is characteristic of a diverse set of physiological and pathophysiological states. For example, human health problems associated with oxidative stress include Parkinson’s disease, Alzheimer’s disease, myocardial infarction, cancer, diabetes, various inflammations, renal failure, and atherosclerosis as well as aging. It has become routine and convenient to screen body fluids, including blood (serum or plasma), saliva, and urine, as well as exhaled breath for small molecules that are biomarkers of oxidative stress to ascertain the oxidative stress status (OSS) of a particular targeted organ or the whole body. Unfortunately, circulating levels of oxidation products and/or antioxidants often do not truly represent the tissue/organ/whole body state of oxidative stress or antioxidant status due to the diverse nature of oxidative reactions, metabolic status, and tissue retention. Hence, the analyst has to bear several important points in mind while ascertaining the state of oxidative stress or antioxidant status by measuring one or two chosen biomarkers in one or two selected sampling sites at any given time.

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Acknowledgments

The authors acknowledge the support from the National Institutes of Health (NIH) through the National Institute of General Medical Science (NIGMS) Grant 5 P2O GM103424-17 and the US Department of Education (US DoE; Title III, HBGI Part B grant number P031B040030). Its contents are solely the responsibility of authors and do not represent the official views of NIH, NIGMS, or US DoE.

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Authors and Affiliations

  1. Department of Environmental Toxicology and the Health Research Center, Colleges of Sciences and Engineering, Southern University and A&M College, Baton Rouge, LA, USA

    Rao M. Uppu

  2. Daniel Woods, Inscent, Inc., Irvine, CA, USA

    Danial Woods

  3. Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA

    Narasimham L. Parinandi

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  1. Rao M. Uppu
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  2. Danial Woods
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  3. Narasimham L. Parinandi
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Correspondence to Rao M. Uppu .

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Editors and Affiliations

  1. Department of Chemistry and Biochemistry, University of Denver, Centennial, CO, USA

    Lawrence J. Berliner

  2. Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Ohio State University College of Medicine, Dorothy M. Davis Heart and Lung Research Institute, Columbus, OH, USA

    Narasimham L. Parinandi

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Uppu, R.M., Woods, D., Parinandi, N.L. (2020). Measurement of Oxidative Stress Status in Human Populations: A Critical Need for a Metabolomic Profiling. In: Berliner, L., Parinandi, N. (eds) Measuring Oxidants and Oxidative Stress in Biological Systems. Biological Magnetic Resonance, vol 34. Springer, Cham. https://doi.org/10.1007/978-3-030-47318-1_8

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