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Diagnosis of Tuberculosis: Microbiological and Imaging Perspective

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PET/CT in Tuberculosis

Abstract

Tuberculosis (TB) is an important public health problem. It was declared as global emergency, and specific goals were established to cut down the mortality and morbidity. Newer technological advancements in the field of microbiology were brought into the mainstream to facilitate the early diagnosis. Advanced imaging such as magnetic resonance imaging (MRI), computed tomography (CT), and 18F-fluorodeoxyglucose positron emission tomography–computed tomography (18F-FDG PET–CT) are helping the physicians in demonstrating lesion extent, serving as guide for biopsy with aspiration for culture, assisting surgery planning, and follow-ups. In this chapter, we try to briefly explain the various microbiological tests and imaging scenario in tuberculosis.

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References

  1. Kochi A. The global tuberculosis situation and the new control strategy of the World Health Organization. Tubercle. 1991;72(1):1–6.

    Article  CAS  Google Scholar 

  2. World Health Organization. WHO Global Tuberculosis Report 2016. WHO, 2018. Available online: http://www.who.int/tb/publications/global_report/en.

  3. Pai M, Denkinger CM, Kik SV, Rangaka MX, Zwerling A, Oxlade O, et al. Gamma interferon release assays for detection of Mycobacterium tuberculosis infection. Clin Microbiol Rev. 2014;27(1):3–20.

    Article  Google Scholar 

  4. Siddiqi K. Clinical diagnosis of smear-negative pulmonary tuberculosis in low-income countries: the current evidence. Lancet Infect Dis. 2003;3:288.

    Article  Google Scholar 

  5. Steingart KR, Henry M, Ng V, Hopewell PC, Ramsay A, Cunningham J, et al. Fluorescence versus conventional sputum smear microscopy for tuberculosis: a systematic review. Lancet Infect Dis. 2006;6(9):570–81.

    Article  Google Scholar 

  6. Tapley A, Switz N, Reber C, Davis JL, Miller C, Matovu JB, et al. Mobile digital fluorescence microscopy for diagnosis of tuberculosis. J Clin Microbiol. 2013;51(6):1774–8.

    Article  Google Scholar 

  7. Cruciani M, Scarparo C, Malena M, Bosco O, Serpelloni G, Mengoli C. Meta-analysis of BACTEC MGIT 960 and BACTEC 460 TB, with or without solid media, for detection of mycobacteria. J Clin Microbiol. 2004;42(5):2321–5.

    Article  CAS  Google Scholar 

  8. World Health Organization. Use of liquid TB culture and drug susceptibility testing (DST) in low- and medium-income settings. Geneva: World Health Organization; 2007.

    Google Scholar 

  9. Ling DI, Zwerling AA, Pai M. GenoType MTBDR assays for the diagnosis of multidrug-resistant tuberculosis: a meta-analysis. Eur Respir J. 2008;32(5):1165–74.

    Article  CAS  Google Scholar 

  10. Steingart KR, Sohn H, Schiller I, et al. Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults. Cochrane Database Syst Rev. 2013;(1):CD009593.

    Google Scholar 

  11. Minion J, Leung E, Menzies D, Pai M. Microscopic-observation drug susceptibility and thin layer agar assays for the detection of drug resistant tuberculosis: a systematic review and meta-analysis. Lancet Infect Dis. 2010;10(10):688–98.

    Article  CAS  Google Scholar 

  12. Marais BJ, Pai M. New approaches and emerging technologies in the diagnosis of childhood tuberculosis. Paediatr Respir Rev. 2007;8(2):124–33.

    Article  Google Scholar 

  13. Steingart KR, Flores LL, Dendukuri N, Schiller I, Laal S, Ramsay A, et al. Commercial serological tests for the diagnosis of active pulmonary and extrapulmonary tuberculosis: an updated systematic review and meta-analysis. PLoS Med. 2011;8(8):e1001062.

    Article  Google Scholar 

  14. Minion J, Leung E, Talbot E, Dheda K, Pai M, Menzies D. Diagnosing tuberculosis with urine lipoarabinomannan: systematic review and meta-analysis. Eur Respir J. 2011;38(6):1398–405.

    Article  CAS  Google Scholar 

  15. Andreu J, Caceres J, Pallisa E, Martinez-Rodriguez M. Radiological manifestations of pulmonary tuberculosis. Eur J Radiol. 2004;51(2):139–49.

    Article  CAS  Google Scholar 

  16. World Health Organization. Tuberculosis prevalence surveys: a handbook. 2011.

    Google Scholar 

  17. Cruz R. Digital radiography, image archiving and image display: practical tips. Can Vet J. 2008;49(11):1122.

    PubMed  PubMed Central  Google Scholar 

  18. Curvo-Semedo L, Teixeira L, Caseiro-Alves F. Tuberculosis of the chest. Eur J Radiol. 2005;55(2):158–72.

    Article  Google Scholar 

  19. Woodring JH, Vandiviere HM, Fried AM, Dillon ML, Williams TD, Melvin IG. Update: the radio-graphic features of pulmonary tuberculosis. AJR Am J Roentgenol. 1986;146(3):497–506.

    Article  CAS  Google Scholar 

  20. McAdams HP, Erasmus J, Winter JA. Radiological manifestations of pulmonary tuberculosis. Radiol Clin N Am. 1995;33(4):655–78.

    CAS  PubMed  Google Scholar 

  21. Ahuja A, Ying M, Yuen YH, Metreweli C. Power Doppler sonography to differentiate tuberculous cervical lymphadenopathy from nasopharyngeal carcinoma. AJNR Am J Neuroradiol. 2001;22:735–40.

    CAS  PubMed  Google Scholar 

  22. Leder RA, Low VH. Tuberculosis of the abdomen. Radiol Clin N Am. 1995;33:691–705.

    CAS  PubMed  Google Scholar 

  23. Suri S, Gupta S, Suri R. Computed tomography in abdominal tuberculosis. Br J Radiol. 1999;72:92–8.

    Article  CAS  Google Scholar 

  24. Takalkar AM, Bruno GL, Reddy M, Lilien DL. Intense FDG activity in peritoneal tuberculosis mimics peritoneal carcinomatosis. Clin Nucl Med. 2007;32:244–6.

    Article  Google Scholar 

  25. Nakano H, Jaramillo E, Watanabe M, Miyachi I, Takahama K, Itoh M. Intestinal tuberculosis: findings on double contrast barium enema. Gastrointest Radiol. 1992;17:108–14.

    Article  CAS  Google Scholar 

  26. Huang YC, Tang YL, Zhang XM, Zeng NL, Li R, Chen TW. Evaluation of primary adrenal insufficiency secondary to tuberculosis adrenalitis with computed tomography and magnetic resonance imaging: current status. World J Radiol. 2015;7:336–42.

    Article  Google Scholar 

  27. Buxi TB, Vohra RB, Sujatha, Byotra SP, Mukherji S, Daniel M. CT enlargement due to tuberculosis: a review of literature with five new cases. Clin Imaging. 1992;16:102–8.

    Article  CAS  Google Scholar 

  28. Pasternak MS, Rubin RH. Urinary tract tuberculosis. In: Schrier RW, editor. Diseases of the kidney and urinary tract. 7th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2001. p. 1017–37.

    Google Scholar 

  29. Burrill J, Williams CJ, Bain G, Conder G, Hine AL, Misra RR. Tuberculosis: a radiologic review. Radiographics. 2007;27:1255–73.

    Article  Google Scholar 

  30. Kollins SA, Hartman GW, Carr DT, Segura JW, Hattery RR. Roentgenographic findings in urinary tract tuberculosis: a 10 year review. Am J Roentgenol Radium Therapy, Nucl Med. 1974;121:487–99.

    Article  CAS  Google Scholar 

  31. Davidson AJ, Hartman DS, Choyke PL, Wagner BJ. Parenchymal disease with normal size and contour. In: Davidson AJ, editor. Davidson’s radiology of the kidney and genitourinary tract. 3rd ed. Philadelphia, PA: Saunders; 1999. p. 327–58.

    Google Scholar 

  32. Kenney PJ. Imaging of chronic renal infections. AJR Am J Roentgenol. 1990;155:485–94.

    Article  CAS  Google Scholar 

  33. Berry M. Diagnostic radiology, urogenital imaging. New Delhi: Jaypee Brothers Publishers; 2003.

    Google Scholar 

  34. Wang LJ, Wong YC, Chen CJ, Lim KE. CT features of genitourinary tuberculosis. J Comput Assist Tomogr. 1997;21:254–8.

    Article  CAS  Google Scholar 

  35. Jung YY, Kim JK, Cho KS. Genitourinary tuberculosis: comprehensive cross-sectional imaging. AJR Am J Roentgenol. 2005;184:143–50.

    Article  Google Scholar 

  36. Harisinghani MG, McLoud TC, Shepard JA, Ko JP, Shroff MM, Mueller PR. Tuberculosis from head to toe. Radiographics. 2000;20:449–70.

    Article  CAS  Google Scholar 

  37. Jaovisidha S, Chen C, Ryu KN, et al. Tuberculous tenosynovitis and bursitis: imaging findings in 21 cases. Radiology. 1996;201(2):507–13.

    Google Scholar 

  38. Martini M, Adjrad A, Boudjemaa A. Tuberculous osteomyelitis: a review of 125 cases. Int Orthop. 1986;10:201–7.

    CAS  PubMed  Google Scholar 

  39. Garg RK. Classic diseases revisited: tuberculosis of the central nervous system. Postgrad Med J. 1999;75:133–40.

    Article  CAS  Google Scholar 

  40. Morgado C, Ruivo N. Imaging meningo-encephalic tuberculosis. Eur J Radiol. 2005;55:188–92.

    Article  Google Scholar 

  41. Gupta RK, Kathuria MK, Pradhan S. Magnetization transfer MR imaging in CNS tuberculosis. AJNR Am J Neuroradiol. 1999;20:867–75.

    CAS  PubMed  Google Scholar 

  42. Gambhir S, Kumar M, Ravina M, Bhoi SK, Kalita J, Misra UK. Role of 18F-FDG PET in demonstrating disease burden in patients with tuberculous meningitis. J Neurol Sci. 2016;370:196–200.

    Google Scholar 

  43. Luthra G, Parihar A, Nath K, Jaiswal S, Prasad KN, Husain N, et al. Comparative evaluation of fungal, tubercular, and pyogenic brain abscesses with conventional and diffusion MR imaging and proton MR spectroscopy. AJNR Am J Neuroradiol. 2007;28:1332.

    Article  CAS  Google Scholar 

  44. Patkar D, Narang J, Yanamandala R, Lawande M, Shah GV. Central nervous system tuberculosis: pathophysiology and imaging findings. Neuroimaging Clin N Am. 2012;22:677–705.

    Article  Google Scholar 

  45. Sinan T, Al-Khawari H, Ismail M, Ben-Nakhi A, Sheikh Spinal M. Tuberculosis: CT and MRI feature. Ann Saudi Med. 2004;24:437–41.

    Article  Google Scholar 

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Gambhir, S., Rangan, K., Ora, M. (2020). Diagnosis of Tuberculosis: Microbiological and Imaging Perspective. In: Sobic Saranovic, D., Vorster, M., Gambhir, S., Pascual, T. (eds) PET/CT in Tuberculosis. Clinicians’ Guides to Radionuclide Hybrid Imaging(). Springer, Cham. https://doi.org/10.1007/978-3-030-47009-8_2

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  • DOI: https://doi.org/10.1007/978-3-030-47009-8_2

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