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Smart Polysaccharide Hydrogels in Drug Delivery and Release

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Advanced Biopolymeric Systems for Drug Delivery

Part of the book series: Advances in Material Research and Technology ((AMRT))

Abstract

Smart hydrogels having extreme biocompatibility and drug loading ability are used in drug release (DR) applications under external stimuli like ultrasound (US). For the smart medicine hydrogels used in US-triggered DR, hydrogel matrix has functionalities like non-toxicity and biocompatibility. In addition, the DR behavior can be controlled by US exposure. It is known that in cancer chemotherapy, protein and gene delivery, and tissue regeneration, such smart hydrogel medicine plays a vital role as drug carriers and release. The hydrogels fabricated from polysaccharides like cellulose and chitin, which retain high content of water and medicine in the polymeric networks, exhibit excellent bio- and cyto-compatibilities and are mainly introduced for DR. It is also reviewed that, from such medicine hydrogels, external stimulant promotes accelerated DR by stimuli like temperature, pH, and enzymes. Especially, US-stimulated DR by cellulose and chitin hydrogels are reviewed as smart polysaccharide hydrogels.

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Abbreviations

ATB:

Agave tequilana Weber bagasse

BSA:

Bovine serum albumin

CH:

Cellulose hydrogel

ChH:

Chitin hydrogel

DD:

Drug delivery

DMAc:

N,N–Dimethylacetamide

DMSO:

Dimethyl sulfoxide

DR:

Drug release

EtO:

HEthanol

H2SO4:

Sulfuric acid

HCl:

Hydrochloric acid

LiCl:

Lithium chloride

MCH:

Mimosa-loaded cellulose hydrogel

NaOCl:

Sodium hypochlorite

NaOH:

Sodium hydroxide

NMMO:

N‐methylmorpholine‐N‐oxide

RMSSR:

Root mean square surface roughness

SCB:

Sugarcane bagasse

SEM:

Scanning electron microscope

SPBM:

Surface scanning probe microscope

TBAF:

Tetrabutylammonium fluoride

WC:

Water content

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Authors and Affiliations

  1. Department of Energy and Environment Sciences, Nagaoka University of Technology, Kamitomioka, 1603-1, Nagaoka, Niigata, 940-2188, Japan

    Harshani Iresha & Takaomi Kobayashi

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  1. Harshani Iresha
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  2. Takaomi Kobayashi
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Correspondence to Takaomi Kobayashi .

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Editors and Affiliations

  1. Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj, Odisha, India

    Amit Kumar Nayak

  2. Department of Pharmacy, Shri Venkateshwara University, Rajabpur, Gajraula, Uttar Pradesh, India

    Md Saquib Hasnain

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Iresha, H., Kobayashi, T. (2020). Smart Polysaccharide Hydrogels in Drug Delivery and Release. In: Nayak, A., Hasnain, M. (eds) Advanced Biopolymeric Systems for Drug Delivery. Advances in Material Research and Technology. Springer, Cham. https://doi.org/10.1007/978-3-030-46923-8_6

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