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Stimuli-Responsive Polymeric Systems for Smart Drug Delivery

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Advanced Biopolymeric Systems for Drug Delivery

Part of the book series: Advances in Material Research and Technology ((AMRT))

Abstract

This chapter provides a general description of smart drug delivery systems (DDSs) based on the use of stimuli-responsive polymers. Smart DDSs have the distinctiveness of carrying out the release of therapeutics at the target sites in a spatially controlled manner. This means that the drug is released with suitable speeds exclusively at the site of action. Specifically, smart DDSs ensure that the drug is not freely extravagate during blood circulation, and only released at specific sites (organs/tissues) where these nanocarriers accumulate through an active or passive targeting strategy. Various polymers-based nanomaterials offer new opportunities for the preparation of smart DDSs due to their unique nanoscale properties and specific bio-functions. In this way, there is a special type of polymers called ‘stimuli-responsive’, ‘intelligent’, ‘smart’ or ‘environmental-sensitive’ polymers, because they have the particularity of responding to small physical or chemical stimuli leading to a macroscopic alteration in their structure/properties. The basis of the different stimulus-sensitive polymers used in the preparation of intelligent DDSs will be presented in the different sections of this chapter taking into account the stimulus that trigger polymer alteration and their specific applications in drug delivery.

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Acknowledgements

The authors acknowledge the support by FONCYT (PICT-2015-2477), CONICET (11220150100344CO) and SECYT-UNC (30720150100698CB, 30920150100233CB and 30720150100225CB). Dariana Aristizabal Bedoya, Francisco Figueroa and Micaela A. Macchione, thank CONICET for the fellowship awarded.

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Authors and Affiliations

  1. Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Química Orgánica, Av. Haya de La Torre esq. Av. Medina Allende, X5000HUA, Córdoba, Argentina

    Dariana Aristizabal Bedoya, Francisco N. Figueroa, Micaela A. Macchione & Miriam C. Strumia

  2. CONICET, Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada (IPQA), Av. Velez Sárfield 1611, X5000HUA, Córdoba, Argentina

    Dariana Aristizabal Bedoya, Francisco N. Figueroa, Micaela A. Macchione & Miriam C. Strumia

  3. Universidad Nacional de Villa María, Instituto Académico Pedagógico de Ciencias Humanas, Arturo Jauretche 1555, Villa María, X5900, Córdoba, Argentina

    Micaela A. Macchione

Authors
  1. Dariana Aristizabal Bedoya
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  2. Francisco N. Figueroa
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  3. Micaela A. Macchione
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  4. Miriam C. Strumia
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Correspondence to Miriam C. Strumia .

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Editors and Affiliations

  1. Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj, Odisha, India

    Amit Kumar Nayak

  2. Department of Pharmacy, Shri Venkateshwara University, Rajabpur, Gajraula, Uttar Pradesh, India

    Md Saquib Hasnain

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Bedoya, D.A., Figueroa, F.N., Macchione, M.A., Strumia, M.C. (2020). Stimuli-Responsive Polymeric Systems for Smart Drug Delivery. In: Nayak, A., Hasnain, M. (eds) Advanced Biopolymeric Systems for Drug Delivery. Advances in Material Research and Technology. Springer, Cham. https://doi.org/10.1007/978-3-030-46923-8_5

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