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The Developmental Interrelation Between the Nervous System and Craniofacial Complex as Evidenced from Craniofacial Malformations

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Fundamentals of Craniofacial Malformations

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Abstract

The craniofacial complex develops during the first trimester of pregnancy, but its final shaping, which is mainly dependent on genetic factors, extends into the second and third trimesters. It is intimately connected with the development of the brain because the numerous signals which control craniofacial development originate in the brain and vice versa. As a result, malformations of one organ may affect the development of the other. Craniofacial anomalies are either isolated, resulting from abnormal development of the first two embryonic pharyngeal arches, or part of multiple malformation syndromes affecting many other organs. They may stem from gene mutations, chromosomal aberrations, or environmental causes induced by teratogens. The craniofacial morphologic changes are not only cosmetic as they may often interfere with important functions such as chewing, swallowing, and respiration and/or cause hearing or visual impairment. We discussed only a small number of craniofacial malformations and their diagnosis and treatment. Following a brief description of the craniofacial development, we discussed oral clefts, craniofacial microsomia, and teratogens that may affect craniofacial development resulting in different malformations and the genetically determined craniosynostosis syndromes. The understanding of these malformations is important in medicine and in dentistry as the approach for diagnosis and treatment is generally multidisciplinary.

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References

  1. Creuzet SE, Martinez S, Le Douarin NM. The cephalic neural crest exerts a critical effect on forebrain and midbrain development. PNAS. 2006;103:14033–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Abramyan J, Richman JM. Craniofacial development: discoveries made in the chicken embryo. Int J Dev Biol. 2018;62:97–107.

    Article  CAS  PubMed  Google Scholar 

  3. Kuratani S. The neural crest origin in the neurocranium in vertebrates. Genesis. 2018;56(6–7):e23213.

    Article  PubMed  Google Scholar 

  4. Kuratani S, Kusakabe R, Hirasawa T. The neural crest and evolution of the head/trunk interface in vertebrates. Dev Biol. 2018;444(Suppl 1):S60–6.

    Article  CAS  PubMed  Google Scholar 

  5. Dworkin S, Boglev Y, Owens H, Goldie SJ. The role of sonic Hedgehog in craniofacial patterning, morphogenesis and cranial neural crest survival. J Dev Biol. 2016;4(3):24. https://doi.org/10.3390/jdb4030024.

    Article  PubMed Central  Google Scholar 

  6. He F, Chen Y. Wnt signaling in lip and palate development. Front Oral Biol. 2012;16:81–90.

    Article  PubMed  Google Scholar 

  7. Chai Y, Maxson RE. Recent advances in craniofacial morphogenesis. Dev Dyn. 2006;235:2353–75.

    Article  PubMed  Google Scholar 

  8. Johnston MC, Bronsky PT. Prenatal craniofacial development: new insights on normal and abnormal mechanisms. Crit Rev Oral Biol Med. 1995;6:368–422.

    Article  CAS  PubMed  Google Scholar 

  9. Moore KL, Persaud TVN, Torchia MG, editors. The developing human: clinically oriented embryology. 10th ed. Philadelphia: Elsevier; 2015. p. 155–93.

    Google Scholar 

  10. Nagarajan M, Sharbidre KG, Bhabad SH, Byrd SE. MR imaging of the fetal face: comprehensive review. Radiographics. 2018;38(3):962–80.

    Article  PubMed  Google Scholar 

  11. Som PM, Naidich TP. Illustrated review of the embryology and development of the facial region, part 1: early face and lateral nasal cavities. AJNR Am J Neuroradiol. 2013;34(12):2233–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Som PM, Naidich TP. Illustrated review of the embryology and development of the facial region, part 2: late development of the fetal face and changes in the face from the newborn to adulthood. AJNR Am J Neuroradiol. 2014;35(1):10–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Kurosaka H. The roles of Hedgehog signaling in upper lip formation. Biomed Res Int. 2015;2015:901041. https://doi.org/10.1155/2015/901041.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Sperber GH, Sperber SM, Gutmann GD. In: Shelto CT, editor. Craniofacial embryogenetics and development. 2nd edn. People Publishing Medical House; 2010, pp 37–60; 131–144.

    Google Scholar 

  15. Tan TY, Kilpatrick N, Farlie PG. Developmental and genetic perspectives on Pierre Robin sequence. Am J Med Genet C Semin Med Genet. 2013;163C(4):295–305.

    Article  PubMed  Google Scholar 

  16. Purnell CA, Janes LE, Klosowiak JL, Gosain AK. Mandibular catch-up growth in Pierre Robin sequence: a systematic review. Cleft Palate Craniofac J. 2018;1055665618774025. https://doi.org/10.1177/1055665618774025.

  17. Bush JO, Jiang R. Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development. Development. 2012;139(2):231–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Smarius B, Loozen C, Manten W, Bekker M, Pistorius L, Breugem C. Accurate diagnosis of prenatal cleft lip/palate by understanding the embryology. World J Methodol. 2017;7(3):93–100.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Kousa YA, Schutte BC. Toward an orofacial gene regulatory network. Dev Dyn. 2016;245(3):220–32.

    Article  CAS  PubMed  Google Scholar 

  20. Weng M, Chen Z, Xiao Q, Li R, Chen Z. A review of FGF signaling in palate development. Biomed Pharmacother. 2018;103:240–7.

    Article  CAS  PubMed  Google Scholar 

  21. Jones KL, editor. Smith’s recognizable patterns of human malformations. 4th ed. Philadelphia: Saunders Company Publishers; 1988. p. 662–706.

    Google Scholar 

  22. Cohen MM Jr. Syndromology: an updated conceptual overview: IX: facial dysmorphology. Int J oral Maxilofac Surg. 1990;19:81–8.

    Article  Google Scholar 

  23. Hammond P. The use of 3D face shape modelling in dysmorphology. Arch Dis Child. 2007;92:1120–6.

    Article  PubMed Central  Google Scholar 

  24. Kirby RS. The prevalence of selected major birth defects in the United States. Semin Perinatol. 2017;41(6):338–44.

    Article  PubMed  Google Scholar 

  25. Caron CJJM, Pluijmers BI, Wolvius EB, Looman CWN, Bulstrode N, Evans RD, et al. Craniofacial and extra-craniofacial anomalies in craniofacial microsomia: a multicenter study of 755 patients. J Craniomaxillofac Surg. 2017;45(8):1302–10.

    Article  PubMed  Google Scholar 

  26. Heike CL, Wallace E, Speltz ML, Siebold B, Werler MM, Hing AV, et al. Characterizing facial features in individuals with craniofacial microsomia: a systematic approach for clinical research. Birth Defects Res A Clin Mol Teratol. 2016;106(11):915–26.

    Article  CAS  PubMed  Google Scholar 

  27. Birgfeld CB, Heike CL, Saltzman BS, Leroux BG, Evans KN, Luquetti DV. Reliable classification of facial phenotypic variation in craniofacial microsomia: a comparison of physical exam and photographs. Head Face Med. 2016;12:14. https://doi.org/10.1186/s13005-016-0109-x.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Brandstetter KA, Patel KG. Craniofacial microsomia. Facial Plast Surg Clin N Am. 2016;24:495–515.

    Article  Google Scholar 

  29. Tuin AJ, Tahiri Y, Paine KM, et al. Clarifying the relationships among the different features of the OMENS1 classification in craniofacial microsomia. Plast Reconstr Surg. 2015;135(1):149e–56e.

    Article  CAS  PubMed  Google Scholar 

  30. Renkema RW, Caron CJJM, Wolvius EB, Dunaway DJ, Forrest CR, Padwa BL, Koudstaal MJ. Central nervous system anomalies in craniofacial microsomia: a systematic review. Int J Oral Maxillofac Surg. 2018;47(1):27–34.

    Article  CAS  PubMed  Google Scholar 

  31. Merritt L. Part 1. Understanding the embryology and genetics of cleft lip and palate. Adv Neonatal Care. 2005;5(2):64–71.

    Article  PubMed  Google Scholar 

  32. Shkoukani MA, Chen M, Vong A. Cleft lip—a comprehensive review. Front Pediatr. 2013;1:53.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Bernheim N, Georges M, Malevez C, De Mey A, Mansbach A. Embryology and epidemiology of cleft lip and palate. B-ENT. 2006;2 Suppl 4:11–9.

    CAS  PubMed  Google Scholar 

  34. Menezes C, de Arruda JA, Silva LV, Monteiro JL, Caribé P, Álvares P, et al. Nonsyndromic cleft lip and/or palate: a multicenter study of the dental anomalies involved. J Clin Exp Dent. 2018;10(8):e746–50.

    PubMed  PubMed Central  Google Scholar 

  35. Sainsbury DCG, Davies A, Wren Y, Southby L, Chadha A, Slator R, Stock NM. The cleft multidisciplinary collaborative: establishing a network to support cleft lip and palate research in the United Kingdom. Cleft Palate Craniofac J. 2018:1055665618790174. https://doi.org/10.1177/1055665618790174.

  36. Shkoukani MA, Lawrence LA, Liebertz DJ, Svider PF. Cleft palate: a clinical review. Birth Defects Res C Embryo Today. 2014;102(4):333–42.

    Article  CAS  PubMed  Google Scholar 

  37. Burg ML, Chai Y, Yao CA, Magee W 3rd, Figueiredo JC. Epidemiology, etiology and treatment of isolated cleft palate. Front Physiol. 2016;7:67. https://doi.org/10.3389/fphys.2016.00067.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Hyoun SC, Obican SG, Scially AR. Teratogen update: methotrexate. Birth Defects Res A. 2012;94:187–207.

    Article  CAS  Google Scholar 

  39. Del Campo M, Kosaki K, Bennett FC, Jones KL. Developmental delay in fetal aminopterin/methotrexate syndrome. Teratology. 1999;60:10–2.

    Article  CAS  PubMed  Google Scholar 

  40. www.reprotox. Methotrexate. Updated: August22, 2018.

  41. Sulik KK, Cook CS, Webster WS. Teratogens and craniofacial malformations: relationship to cell death. Development. 1988;103(Suppl):213–31.

    Article  CAS  PubMed  Google Scholar 

  42. Weber-Schoendorfer C, Chambers C, Wacker E, Beghin D, Bernard N, on behalf of the Network of French Pharmacovigilance Centers, et al. Pregnancy outcome after rheumatologic methotrexate (MTX) treatment prior to or during early pregnancy: a prospective multicenter cohort study. Arthritis Rheumatol. 2014;66(5):1101–110.

    Google Scholar 

  43. www.reprptox. Isotretinoin. Updated 27.9.2018.

  44. Benke PJ. The isotretinoin teratogen syndrome. J Am Med Assoc. 1984;251:3267–9.

    Article  CAS  Google Scholar 

  45. Braun JT, Franciosi RA, Mastri AR, Drake RM, O’Neil BL. Isotretinoin dysmorphic syndrome. Lancet. 1984;1:506–7.

    Article  CAS  PubMed  Google Scholar 

  46. Jahn AF, Ganti K. Major auricular malformations due to Accutane (isotretinoin). Laryngoscope. 1987;97(7 Pt 1):832–5.

    CAS  PubMed  Google Scholar 

  47. Lammer EJ, Chen DT, Hoar RM, Agnish ND, Benke PJ, Braun JT, et al. Retinoic acid embryopathy. N Engl J Med. 1985;313(14):837–41.

    Article  CAS  PubMed  Google Scholar 

  48. Adams J. The neurobehavioral teratology of retinoids: a 50-year history. Birth Defects Res A Clin Mol Teratol. 2010;88(10):895–905.

    Article  CAS  PubMed  Google Scholar 

  49. www.reprotox. Cyclophosphamide. Updated 29.9.2018.

  50. Kirshon B, et al. Teratogenic effects of first trimester cyclophosphamide therapy. Obstet Gynecol. 1988;72:462.

    CAS  PubMed  Google Scholar 

  51. Zemlickis D, Lishner M, Erlich R, Koren G. Teratogenicity and carcinogenicity in a twin exposed in utero to cyclophosphamide. Teratog Carcinog Mutagen. 1993;13:139–43.

    Article  CAS  PubMed  Google Scholar 

  52. Vaux KK, Kahole N, Jones KL. Pattern of malformation secondary to prenatal exposure to cyclophosphamide (abstract). Teratology. 2002;65:297.

    Google Scholar 

  53. Rengasamy P. Congenital malformations attributed to prenatal exposure to cyclophosphamide. Am J Med Genet. 1999;86(3):237–41.

    Google Scholar 

  54. Leyder M, Laubach M, Breugelmans M, et al. Specific congenital malformations after exposure to cyclophosphamide, epirubicin and 5-fluorouracil during the first trimester of pregnancy. Gynecol Obstet Invest. 2011;71(2):141–4.

    Article  CAS  PubMed  Google Scholar 

  55. Enns GM, Roeder E, Chan RT, Ali-Khan Catts Z, Cox VA, Golabi M. Apparent cyclophosphamide (cytoxan) embryopathy: a distinct phenotype? Anti Cancer Agents Med Chem. 2017;17(9):1211–27.

    Google Scholar 

  56. Ostensen M, Ramsey-Goldman R. Treatment of inflammatory rheumatic disorders in pregnancy: what are the safest treatment options? Drug Saf. 1998;19(5):389–410.

    Article  CAS  PubMed  Google Scholar 

  57. www.reprotox. Mycophenolate mofetil. Updated 27.7. 2018.

  58. Perez-Aytes A, Ledo A, Boso V, Sáenz P, Roma E, Poveda JL, Vento M. In utero exposure to mycophenolate mofetil: a characteristic phenotype? Am J Med Genet A. 2008;146A(1):1–7.

    Article  PubMed  Google Scholar 

  59. Merlob P, Stahl B, Klinger G. Tetrada of the possible mycophenolate mofetil embryopathy: a review. Reprod Toxicol. 2009;28(1):105–8.

    Article  CAS  PubMed  Google Scholar 

  60. Coscia LA, Constantinescu S, Moritz MJ, Frank AM, Ramirez CB, Doria C, McGrory CH, Armenti VT. Report from the National Transplantation Pregnancy Registry (NTPR): Outcomes of pregnancy after transplantation. In: Cecka JM, Terasaki PI, editors. Clinical transplants. Los Angeles, CA: Terasaki Foundation Laboratory; 2008. p. 91–107.

    Google Scholar 

  61. Hoeltzenbein M, Elefant E, Vial T, Finkel-Pekarsky V, Stephens S, Clementi M, et al. Teratogenicity of mycophenolate confirmed in a prospective study of the European Network of Teratology Information Services. Am J Med Genet. 2012;158A:588–96.

    Article  PubMed  CAS  Google Scholar 

  62. www.reprotox. Valproic acid. Updated 12.2018.

  63. Kozma C. Valproic acid embryopathy: report of two siblings with further expansion of the phenotypic abnormalities and a review of the literature. Am J Med Genet. 2001;98(2):168–75.

    Article  CAS  PubMed  Google Scholar 

  64. Ornoy A. Valproic acid in pregnancy: how much are we endangering the embryo and fetus? A review. Reprod Toxicol. 2009;28:1–10.

    Article  CAS  PubMed  Google Scholar 

  65. Bromfield BE, Dworetzky BA, Wyszynski DF, Smith CR, Baldwin EJ, Holmes LB. Valproate teratogenicity and epilepsy syndrome. Epilepsia. 2008;49:1122–4.

    Article  CAS  Google Scholar 

  66. Ornoy A, Arnon J, Shechtman S, Diav-Citrin O. The developmental effects of maternal antiepileptic drugs with special emphasis on carbamazepine. Reprod Toxicol. 2004;19:248–9.

    Google Scholar 

  67. Ornoy A, Cohen E. Outcome of children born to epileptic mothers treated with carbamazepine during pregnancy. Arch Dis Child. 1996;75:515–20.

    Article  Google Scholar 

  68. Kelly TE. Teratogenicity of antiepileptic drugs. Review of the literature. Am J Med Genet. 1984;19:413–34.

    Article  CAS  PubMed  Google Scholar 

  69. www.reprotox. Alcohol, ethyl. Updated 6.7. 2018.

  70. Clarren SK. Recognition of fetal alcohol syndrome. JAMA. 1981;245:2436–9.

    Article  CAS  PubMed  Google Scholar 

  71. Senturias Y, Asamoah A. Fetal alcohol spectrum disorders: guidance for recognition, diagnosis, differential diagnosis and referral. Curr Probl Pediatr Adolesc Health Care. 2014;44(4):88–95.

    Article  PubMed  Google Scholar 

  72. Martinez-Frias ML, Bermejo E, Rodriguez-Pinilla E, Frias JL. Risk for congenital anomalies associated with different sporadic and daily doses of alcohol consumption during pregnancy: a case-control study. Birth Defects Res A. 2004;70:194–200.

    Article  CAS  Google Scholar 

  73. Smith SM, Garic A, Flentke GR, Berres ME. Neural crest development in fetal alcohol syndrome. Birth Defects Res C Embryo Today. 2014;102(3):210–20.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Liyanage VR, Curtis K, Zachariah RM, Chudley AE, Rastegar M. Overview of the genetic basis and epigenetic mechanisms that contribute to FASD pathobiology. Curr Top Med Chem. 2017;17(7):808–28.

    Article  CAS  PubMed  Google Scholar 

  75. Chater-Diehl EJ, Laufer BI, Singh SM. Changes to histone modifications following prenatal alcohol exposure: an emerging picture. Alcohol. 2017;60:41–52.

    Article  CAS  PubMed  Google Scholar 

  76. www.reprotox. Cigarette smoking. Updated 23.8.2018.

  77. Xuan Z, Zhongpeng Y, Yanjun G, Jiaqi D, Yuchi Z, Bing S, Chenghao L. Maternal active smoking and risk of oral clefts: a meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122(6):680–90.

    Article  PubMed  Google Scholar 

  78. Fried PA, Watkinson B, Gray R. Differential effects on cognitive functioning in 13- to 16-year-olds prenatally exposed to cigarettes and marihuana. Neurotoxicol Teratol. 2003;25(4):427–36.

    Article  CAS  PubMed  Google Scholar 

  79. Malik S, Cleves MA, Honein MA, Romitti PA, Botto LD, Yang S, Hobbs CA. Maternal smoking and congenital heart defects. Pediatrics. 2008;121:e810–6.

    Article  PubMed  Google Scholar 

  80. Garrocho-Rangel A, Manriquez-Olmos L, Flores-Velazquez J, Rosales-Berber MA, Martinez-Rider R, Pozos-Guillen A. Non-syndromic craniosynostosis in children: scoping review. Med Oral Patol Oral Cir Bucal. 2018;23(4):e421–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  81. Kutkowska-Kaźmierczak A, Gos M, Obersztyn E. Craniosynostosis as a clinical and diagnostic problem: molecular pathology and genetic counseling. J Appl Genet. 2018;59(2):133–47.

    Article  PubMed  CAS  Google Scholar 

  82. Ko JM. Genetic syndromes associated with craniosynostosis. J Korean Neurosurg Soc. 2016;59(3):187–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Shim KW, Park EK, Kim JS, Kim YO, Kim DS. Neurodevelopmental problems in non-syndromic craniosynostosis. J Korean Neurosurg Soc. 2016;59(3):242–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. Shim KW, Lee MJ, Lee MC, Park EK, Kim DS, Hong H, Kim YO. Computer-assisted shape descriptors for skull morphology in craniosynostosis. Childs Nerv Syst. 2016;32(3):511–7.

    Article  PubMed  Google Scholar 

  85. Buchanan EP, Xue Y, Xue AS, Olshinka A, Lam S. Multidisciplinary care of craniosynostosis. J Multidiscip Healthc. 2017;10:263–70.

    Article  PubMed  PubMed Central  Google Scholar 

  86. Liu C, Cui Y, Luan J, Zhou X, Han J. The molecular and cellular basis of Apert syndrome. Intractable Rare Dis Res. 2013;2(4):115–22.

    PubMed  PubMed Central  Google Scholar 

  87. Das S, Munshi A. Research advances in Apert syndrome. J Oral Biol Craniofac Res. 2018;8(3):194–9.

    Article  CAS  PubMed  Google Scholar 

  88. Al-Namnam NM, Hariri F, Thong MK, Rahman ZA. Crouzon syndrome: genetic and intervention review. J Oral Biol Craniofac Res. 2019;9(1):37–9.

    Article  CAS  PubMed  Google Scholar 

  89. Giancotti A, D’Ambrosio V, Marchionni E, Squarcella A, Aliberti C, La Torre R, et al. Pfeiffer syndrome: literature review of prenatal sonographic findings and genetic diagnosis. J Matern Fetal Neonatal Med. 2017;30(18):2225–31.

    Article  PubMed  Google Scholar 

  90. Williamson I, Arlt W, Shakleton C, Kelley RI, Braddock SR. Linking Antley-Bixler syndrome and congenital adrenal hyperplasia; a novel case of p450 oxidoreductase deficiency. Am J Med Genet A. 2006;140A:1797–803.

    Article  CAS  PubMed  Google Scholar 

  91. Oldani E, Garel C, Bucourt M, Carbillon L. Prenatal diagnosis of Antley-Bixler syndrome and POR deficiency. Am J Case Rep. 2015;16:882–5.

    Article  PubMed  PubMed Central  Google Scholar 

  92. Reardon W, Winter RM. Saethre-Chotzen syndrome. J Med Genet. 1994;31(5):393–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  93. Cai J, Goodman BK, Patel AS, Mulliken JB, Van Maldergem L, Hoganson GE, et al. Increased risk for developmental delay in Saethre-Chotzen syndrome is associated with TWIST deletions: an improved strategy for TWIST mutation screening. Hum Genet. 2003;114(1):68–76.

    Article  CAS  PubMed  Google Scholar 

  94. Doherty ES, Lacbawan F, Hadley DW, Brewer C, Zalewski C, Kim HJ, et al. Muenke syndrome (FGFR3-related craniosynostosis): expansion of the phenotype and review of the literature. Am J Med Genet A. 2007;143A(24):3204–15.

    Article  CAS  PubMed  Google Scholar 

  95. Grutzner E, Gorlin RJ. Craniofrontonasal dysplasia: phenotypic expression in females and males and genetic considerations. Oral Surg Oral Med Oral Pathol. 1988;65(4):436–44.

    Article  CAS  PubMed  Google Scholar 

  96. Johnson D, Wilkie AO. Craniosynostosis. Eur J Hum Genet. 2011;19(4):369–76.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  97. Tahiri Y, Bartlett SP, Gilardino MS. Evidence-based medicine: nonsyndromic craniosynostosis. Plast Reconstr Surg. 2017;140(1):177e–91e.

    Article  CAS  PubMed  Google Scholar 

  98. Lan Y, Jia S, Jiang R. Molecular patterning of the mammalian dentition. Semin Cell Dev Biol. 2014;25–26:61–70.

    Article  PubMed  CAS  Google Scholar 

  99. Hovorakova M, Lesot H, Peterka M, Peterkova R. Early development of the human dentition revisited. J Anat. 2018;233:135–45.

    Article  PubMed  PubMed Central  Google Scholar 

  100. Sharpe PT. Neural crest and tooth morphogenesis. Adv Dent Res. 2001;15:4–7.

    Article  CAS  PubMed  Google Scholar 

  101. Seppala M, Fraser GJ, Birjandi AA, Xavier GM, Cobourne MT. Sonic Hedgehog signaling and development of the dentition. J Dev Biol. 2017;5(2):6. https://doi.org/10.3390/jdb5020006.

    Article  CAS  PubMed Central  Google Scholar 

  102. Xavier GM, Seppala M, Barrell W, Birjandi AA, Geoghegan F, Cobourne MT. Hedgehog receptor function during craniofacial development. Dev Biol. 2016;415(2):198–215.

    Article  CAS  PubMed  Google Scholar 

  103. Cobourne MT, Sharpe PT. Diseases of the tooth: the genetic and molecular basis of inherited anomalies affecting the dentition. Wiley Interdiscip Rev Dev Biol. 2013;2(2):183–212.

    Article  PubMed  Google Scholar 

  104. Klein OD, Oberoi S, Huysseune A, Hovorakova M, Peterka M, Peterkova R. Developmental disorders of the dentition: an update. Am J Med Genet C Semin Med Genet. 2013;163C(4):318–32.

    Article  PubMed  Google Scholar 

  105. Menezes C, de Arruda JA, Silva LV, Monteiro JL, Caribé P, Álvares P, Almeida MC, Coelli JC, Goldemberg F, Silveira M, Sobral AP, Bueno DF. Nonsyndromic cleft lip and/or palate: a multicenter study of the dental anomalies involved. J Clin Exp Dent. 2018;10(8):e746–50.

    PubMed  PubMed Central  Google Scholar 

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Conflict of Interest Statement

The author declares that he has no conflict of interest. This review was not supported by any specific research grant.

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  1. Laboratory of Teratology, Department of Medical Neurobiology, Israel Canada Medical Research Institute, Hebrew University Hadassah Medical School, Jerusalem, Israel

    Asher Ornoy

  2. Adelson School of Medicine, Ariel University, Ariel, Israel

    Asher Ornoy

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  1. Craniofacial Center, Kieferklinik Münster, Münster, Germany

    Ulrich Meyer

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Ornoy, A. (2021). The Developmental Interrelation Between the Nervous System and Craniofacial Complex as Evidenced from Craniofacial Malformations. In: Meyer, U. (eds) Fundamentals of Craniofacial Malformations. Springer, Cham. https://doi.org/10.1007/978-3-030-46024-2_4

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