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Using Two- and Three-Dimensional Human iPSC Culture Systems to Model Psychiatric Disorders

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Neurodevelopmental Disorders

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 25))

Abstract

Psychiatric disorders are among the most challenging human diseases to understand at a mechanistic level due to the heterogeneity of symptoms within established diagnostic categories, the general absence of focal pathology, and the genetic complexity inherent in these mostly polygenic disorders. Each of these features presents unique challenges to disease modeling for biological discovery, drug development, or improved diagnostics. In addition, live human neural tissue has been largely inaccessible to experimentation, leaving gaps in our knowledge derived from animal models that cannot fully recapitulate the features of the disease, indirect measures of brain function in human patients, and from analyses of postmortem tissue that can be confounded by comorbid conditions and medication history.

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Authors and Affiliations

  1. Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Kimberly M. Christian, Hongjun Song & Guo-li Ming

  2. Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Kimberly M. Christian, Hongjun Song & Guo-li Ming

  3. Department of Developmental and Cell Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Hongjun Song & Guo-li Ming

  4. Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Hongjun Song & Guo-li Ming

  5. Institute for Epigenetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Hongjun Song

  6. Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Guo-li Ming

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  1. Kimberly M. Christian
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Correspondence to Kimberly M. Christian .

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Editors and Affiliations

  1. Department of Neuroscience and Cell Biology/Pediatrics, Rutgers Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA

    Emanuel DiCicco-Bloom

  2. Department of Neuroscience and Cell Biology, Center for Advanced Biotechnology and Medicine, Rutgers Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA

    James H. Millonig

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Christian, K.M., Song, H., Ming, Gl. (2020). Using Two- and Three-Dimensional Human iPSC Culture Systems to Model Psychiatric Disorders. In: DiCicco-Bloom, E., Millonig, J. (eds) Neurodevelopmental Disorders . Advances in Neurobiology, vol 25. Springer, Cham. https://doi.org/10.1007/978-3-030-45493-7_9

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