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Idiopathic Ventricular Fibrillation and Early Repolarization Syndrome

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Clinical Cardiogenetics

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Abstract

Idiopathic ventricular fibrillation (IVF) is a rare condition in which patients without any major structural heart disease develop VF and often suffer from sudden cardiac death (SCD). IVF may contain multiple forms by clinical manifestations and possible pathogenetic backgrounds. In this Chapter, IVF is described as two groups: early repolarization syndrome (ERS), and IVF in a narrow sense excluding ERS. Although the early repolarization pattern in ECG is common, ERS is a very rare but potentially highly malignant. The mechanism and genetic background of ERS have not been fully clarified. Both the impairment of repolarization and conduction are postulated to explain ERS. IVF without ER pattern is also rare, and the understanding of its genetic background is limited. Recent findings indicate that His-Purkinje conduction disturbances are involved in some part of IVF without ER.

The authors have no conflicts of interest to declare.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan

    Tetsuo Sasano

  2. Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan

    Masayasu Hiraoka

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  1. Tetsuo Sasano
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Correspondence to Tetsuo Sasano .

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Editors and Affiliations

  1. Consultant Cardiologist at the OLVG Hospital, Amsterdam, The Netherlands

    Hubert F. Baars

  2. Utrecht University, Utrecht, The Netherlands

    Pieter A. F. M. Doevendans

  3. Amsterdam University Medical Center, Amsterdam, The Netherlands

    Arjan C. Houweling

  4. University Medical Center Utrecht, Utrecht, The Netherlands

    J. Peter van Tintelen

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Sasano, T., Hiraoka, M. (2020). Idiopathic Ventricular Fibrillation and Early Repolarization Syndrome. In: Baars, H.F., Doevendans, P.A.F.M., Houweling, A.C., van Tintelen, J.P. (eds) Clinical Cardiogenetics. Springer, Cham. https://doi.org/10.1007/978-3-030-45457-9_16

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