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International Work-Conference on Bioinformatics and Biomedical Engineering

IWBBIO 2020: Bioinformatics and Biomedical Engineering pp 87–97Cite as

Comparison of Corneal Morphologic Parameters and High Order Aberrations in Keratoconus and Normal Eyes

Part of the Lecture Notes in Computer Science book series (LNBI,volume 12108)

Abstract

The aim of this study is evaluating the influence of corneal geometry in the optical system’s aberrations, and its usefulness as diagnostic criterion for keratoconus.159 normal eyes (normal group, mean age 37.8 ± 11.6 years) and 292 eyes with the diagnosis of keratoconus (keratoconus group, mean age 42.2 ± 17.6 years) were included in this study. All eyes received a comprehensive ophthalmologic examination. A virtual 3D model of each eye was made using CAD software and different anatomical parameters related with surface and volume were measured. Statistically significant differences were found for all anatomical parameters (all p < 0.001). AUROC analysis showed that all parameters reached values above 0.7, with the exception of the total corneal surface area (TCSAA-S). In conclusion, the methodology explained in this research, that bases in anatomical parameters obtained from a virtual corneal model, allow to analyze the diagnostic value of corneal geometry correlation with optical aberrations in keratoconus pathology.

Keywords

  • Ophthalmology
  • Corneal apex
  • Computer-Aided Design (CAD)
  • Computational modelling
  • Scheimpflug technology

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Funding

This publication has been carried out in the framework of the Thematic Network for Co-Operative Research in Health (RETICS), reference number RD16/0008/0012, financed by the Carlos III Health Institute–General Subdirection of Networks and Cooperative Investigation Centers (R&D&I National Plan 2013–2016) and the European Regional Development Fund (FEDER).

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Authors and Affiliations

  1. Department of Structures, Construction and Graphic Expression, Technical University of Cartagena, 30202, Cartagena, Spain

    Jose Sebastián Velázquez & Francisco Cavas

  2. Technology Centre for IT and Communications (CENTIC), Scientific Park of Murcia, 30100, Murcia, Spain

    Jose Miguel Bolarín

  3. Keratoconus Unit of Vissum Corporation Alicante, 03016, Alicante, Spain

    Jorge Alió

  4. Department of Ophthalmology, Miguel Hernández University of Elche, 03202, Alicante, Spain

    Jorge Alió

Authors
  1. Jose Sebastián Velázquez
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  2. Francisco Cavas
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  3. Jose Miguel Bolarín
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  4. Jorge Alió
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Corresponding author

Correspondence to Francisco Cavas .

Editor information

Editors and Affiliations

  1. University of Granada, Granada, Spain

    Prof. Ignacio Rojas

  2. University of Granada, Granada, Spain

    Prof. Olga Valenzuela

  3. University of Granada, Granada, Spain

    Prof. Fernando Rojas

  4. University of Granada, Granada, Spain

    Luis Javier Herrera

  5. University of Chicago and Fundacion Progreso y Salud, Granada, Spain

    Dr. Francisco Ortuño

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Velázquez, J.S., Cavas, F., Bolarín, J.M., Alió, J. (2020). Comparison of Corneal Morphologic Parameters and High Order Aberrations in Keratoconus and Normal Eyes. In: Rojas, I., Valenzuela, O., Rojas, F., Herrera, L., Ortuño, F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2020. Lecture Notes in Computer Science(), vol 12108. Springer, Cham. https://doi.org/10.1007/978-3-030-45385-5_8

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  • DOI: https://doi.org/10.1007/978-3-030-45385-5_8

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