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Role of Surgery for Metastatic Melanoma

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Current Management of Melanoma

Part of the book series: Updates in Surgery ((UPDATESSURG))

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Abstract

As happened for other solid malignancies (colorectal cancer, sarcoma), the search for effective medical treatments has led to disease stability and an increase in surgical indications also for patients with metastatic melanoma. The surgical indications in this disease setting can be summarized as: collection of biological material; treatment of oligometastatic disease; treatment beyond progression; palliation surgery. In selected cases, surgical therapy has been shown to provide an improvement in overall survival. The role of surgery in urgency and emergency settings is not well defined in the literature.

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References

  1. Faries MB, Thompson JF, Cochran AJ, et al. Completion dissection or observation for sentinel-node metastasis in melanoma. N Engl J Med. 2017;376(23):2211–22.

    Article  Google Scholar 

  2. Leiter U, Stadler R, Mauch C, et al. Complete lymph node dissection versus no dissection in patients with sentinel lymph node biopsy positive melanoma (DeCOG-SLT): a multicentre, randomised, phase 3 trial. Lancet Oncol. 2016;17(6):757–67.

    Article  Google Scholar 

  3. National Comprehensive Cancer Network. NCCN Guidelines: Melanoma. https://www.nccn.org/professionals/physician_gls/default.aspx.

  4. Bello DM. Indications for the surgical resection of stage IV disease. J Surg Oncol. 2019;119(2):249–61.

    Article  Google Scholar 

  5. Gershenwald JE, Scolyer RA. Melanoma staging: American joint committee on Cancer (AJCC) 8th edition and beyond. Ann Surg Oncol. 2018;25(8):2105–10.

    Article  Google Scholar 

  6. Ollila DW, Essner R, Wanek LA, Morton DL. Surgical resection for melanoma metastatic to the gastrointestinal tract. Arch Surg. 1996;131(9):975–9.

    Article  CAS  Google Scholar 

  7. Agrawal S, Yao TJ, Coit DG. Surgery for melanoma metastatic to the gastrointestinal tract. Ann Surg Oncol. 1999;6(4):336–44.

    Article  CAS  Google Scholar 

  8. Wood TF, DiFronzo LA, Rose DM, et al. Does complete resection of melanoma metastatic to solid intra-abdominal organs improve survival? Ann Surg Oncol. 2001;8(8):658–62.

    Article  CAS  Google Scholar 

  9. Panagiotou I, Brountzos EN, Bafaloukos D, et al. Malignant melanoma metastatic to the gastrointestinal tract. Melanoma Res. 2002;12(2):169–73.

    Article  CAS  Google Scholar 

  10. Petersen RP, Hanish SI, Haney JC, et al. Improved survival with pulmonary metastasectomy: an analysis of 1720 patients with pulmonary metastatic melanoma. J Thorac Cardiovasc Surg. 2007;133(1):104–10.

    Article  Google Scholar 

  11. Collinson FJ, Lam TK, Bruijn WMJ, et al. Long-term survival and occasional regression of distant melanoma metastases after adrenal metastasectomy. Ann Surg Oncol. 2008;15(6):1741–9.

    Article  CAS  Google Scholar 

  12. Mittendorf EA, Lim SJ, Schacherer CW, et al. Melanoma adrenal metastasis: natural history and surgical management. Am J Surg. 2008;195(3):363–8. discussion 368–9.

    Article  Google Scholar 

  13. Robert C, Ribas A, Schachter J, et al. Pembrolizumab versus ipilimumab in advanced melanoma (KEYNOTE-006): post-hoc 5-year results from an open-label, multicentre, randomised, controlled, phase 3 study. Lancet Oncol. 2019;20(9):1239–51.

    Article  CAS  Google Scholar 

  14. Chapman PB, Robert C, Larkin J, et al. Vemurafenib in patients with BRAFV600 mutation-positive metastatic melanoma: final overall survival results of the randomized BRIM-3 study. Ann Oncol. 2017;28(10):2581–7.

    Article  CAS  Google Scholar 

  15. Hauschild A, Grob J-J, Demidov LV, et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet. 2012;380(9839):358–65.

    Article  CAS  Google Scholar 

  16. Spagnolo F, Ghiorzo P, Orgiano L, et al. BRAF-mutant melanoma: treatment approaches, resistance mechanisms, and diagnostic strategies. OncoTargets Ther. 2015;8:157–68.

    Article  CAS  Google Scholar 

  17. Queirolo P, Spagnolo F. BRAF plus MEK-targeted drugs: a new standard of treatment for BRAF-mutant advanced melanoma. Cancer Metastasis Rev. 2017;36(1):35–42.

    Article  CAS  Google Scholar 

  18. Borcoman E, Nandikolla A, Long G, et al. Patterns of response and progression to immunotherapy. Am Soc Clin Oncol Educ Book. 2018;38:169–78.

    Article  Google Scholar 

  19. Guida M, Bartolomeo N, De Risi I, et al. The management of oligoprogression in the landscape of new therapies for metastatic melanoma. Cancers (Basel). 2019;11(10):1559. https://doi.org/10.3390/cancers11101559.

    Article  CAS  Google Scholar 

  20. Cadossi R, Ronchetti M, Cadossi M. Locally enhanced chemotherapy by electroporation: clinical experiences and perspective of use of electrochemotherapy. Future Oncol. 2014;10(5):877–90.

    Article  CAS  Google Scholar 

  21. Mir LM. Therapeutic perspectives of in vivo cell electropermeabilization. Bioelectrochemistry. 2001;53(1):1–10.

    Article  CAS  Google Scholar 

  22. Campana LG, Mocellin S, Basso M, et al. Bleomycin-based electrochemotherapy: clinical outcome from a single institution’s experience with 52 patients. Ann Surg Oncol. 2009;16(1):191–9.

    Article  Google Scholar 

  23. Tremble LF, O’Brien MA, Soden DM, Forde PF. Electrochemotherapy with cisplatin increases survival and induces immunogenic responses in murine models of lung cancer and colorectal cancer. Cancer Lett. 2019;442:475–82.

    Article  CAS  Google Scholar 

  24. Mir LM, Gehl J, Sersa G, et al. Standard operating procedures of the electrochemotherapy: instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the Cliniporator by means of invasive or non-invasive electrodes. Eur J Cancer Suppl. 2006;4(11):14–25.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Surgical Clinic Unit 1, Department of Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy

    Franco De Cian & Matteo Mascherini

Authors
  1. Franco De Cian
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  2. Matteo Mascherini
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Correspondence to Franco De Cian .

Editor information

Editors and Affiliations

  1. Department of Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy

    Ferdinando Cafiero

  2. Department of Surgery, IRCCS Ospedale Policlinico San Martino, Genoa, Italy

    Franco De Cian

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De Cian, F., Mascherini, M. (2021). Role of Surgery for Metastatic Melanoma. In: Cafiero, F., De Cian, F. (eds) Current Management of Melanoma. Updates in Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-45347-3_15

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  • DOI: https://doi.org/10.1007/978-3-030-45347-3_15

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-45346-6

  • Online ISBN: 978-3-030-45347-3

  • eBook Packages: MedicineMedicine (R0)

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