Abstract
Antimicrobial chitosan–polyethylene oxide (CS-PEO) nanofibrous mats containing ZnO nanoparticles (NPs) and hydrocortisone-imipenem/cilastatin-loaded ZnO NPs were produced by electrospinning technique. The FE-SEM images displayed that the spherical ZnO NPs were ~70–200 nm in size and the CS-PEO nanofibers were very uniform and free of any beads which had average diameters within the range of ~20–130 nm. The hydrocortisone release increased to 82% within first 12 h while the release rate of imipenem/cilastatin was very much slower so that 20% of the drug was released during this period of time suggesting this nanofibrous mat is very suitable to inhibit inflammation (by hydrocortisone) and infection (using imipenem/cilastatin antibiotic and ZnO NPs) principally for the wound dressing purposes.
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Authors would like to appreciatively express their thanks to the Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.
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Shariatinia, Z., Fazli, Y. (2020). Biocompatible Electrospun Nanofibrous Mats Designed for Controlled Co-release of Hydrocortisone and Imipenem/Cilastatin Drugs. In: Mirzadeh, H., Katbab, A. (eds) Eco-friendly and Smart Polymer Systems. ISPST 2018. Springer, Cham. https://doi.org/10.1007/978-3-030-45085-4_6
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DOI: https://doi.org/10.1007/978-3-030-45085-4_6
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