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Wolff–Parkinson–White Syndrome

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Heart Rhythm Disorders

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Abstract

The Wolff-Parkinson-White or WPW syndrome, has held the interest of internists, cardiologists, anatomists for nearly a century, and after the advent of intracardiac recordings and stimulation, it has held the fascination of cardiothoracic surgeons, and above all, cardiac electrophysiologists. In this chapter the author discusses several aspects of the syndrome including its history, prevalence, mechanism, the tachycardias associated with the syndrome, the natural history and risk stratification of patients with the WPW Syndrome.

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References

  1. Wolff L, Parkinson J, White PD. Bundle-branch block with short P-R interval in healthy young people prone to paroxysmal tachycardia. Am Heart J. 1930;5:685–704.

    Google Scholar 

  2. Wilson FN. A case in which the Vagus influenced the form of the ventricular complex of the electrocardiogram. Arch Int Med. 1915;16:1008.

    Google Scholar 

  3. Wedd AM. Paroxysmal tachycardia. Arch Int Med. 1921;27:571.

    Google Scholar 

  4. Bain CWC, Hamilton CK. Electrocardiographic changes in rheumatic carditis. Lancet. 1926;1:807–9.

    Google Scholar 

  5. Bach F. Paroxysmal tachycardia of forty-eight years’ duration and right branch bundle block. Proc R Soc Med. 1928/29;22:412–4.

    Google Scholar 

  6. Hamburger WW. Bundle branch block: four cases of intraventricular block showing some interesting and unusual clinical features. Med Clin North Am. 1929;13:343–62.

    Google Scholar 

  7. Hiss RG, Lamb LE. Electrocardiographic findings in 122,043 individuals. Circulation. 1962;25:947–61.

    CAS  PubMed  Google Scholar 

  8. Munger TM, Packer DL, Hammill SC, Feldman BJ, Bailey KR, Ballard DJ, Holmes DR Jr, Gersh BJ. A population study of the natural history of Wolff-Parkinson-White syndrome in Olmsted County, Minnesota, 1953–1989. Circulation. 1993;87:866–73.

    CAS  PubMed  Google Scholar 

  9. Flensted-Jensen E. Wolff-Parkinson-White syndrome. A long-term follow-up of 47 cases. Acta Med Scand. 1969;186:65–74.

    CAS  PubMed  Google Scholar 

  10. Klein GJ, Bashore TM, Sellers TD, et al. Ventricular fibrillation in the Wolff-Parkinson-White syndrome. N Engl J Med. 1979;301:1080–5.

    CAS  PubMed  Google Scholar 

  11. Hunter A, Papp C, Parkinson J. Syndrome of short P-R interval, apparent bundle branch block and associated paroxysmal tachycardia. Br Heart J. 1940;2:107.

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Sodi-Pallares D, Soberon J, Thomsen P, Fisleder BL, Estandia A. Contribucional estudio del sindrome de W.P.W. por as derivaciones intracavitarias. Arch Inst Cardiol Mex. 1948;8:1.

    Google Scholar 

  13. Sodi-Pallares D, Calder R. New basis in electrocardiography. St. Louis: C. V. Mosby Co.; 1956.

    Google Scholar 

  14. Prinzmetal M, Kennamer R, Corday E, Osborne JA, Fields J, Smith LA. Accelerated conduction: the Wolff-Parkinson- White syndrome and related conditions. NewYork: Grune & Stratton; 1952.

    Google Scholar 

  15. Langendorf R, Lev M, Pick R. Auricular fibrillation with anomalous A-V excitation (WPW syndrome) imitating ventricular paroxysmal tachycardia: case report with clinical and autopsy findings and a critical review of the literature. Acta Cardiol. 1952;7:241.

    CAS  PubMed  Google Scholar 

  16. Kent AFS. Researches on the structure and function of the mammalian heart. J Physiol. 1893;14:233.

    Google Scholar 

  17. Kent AFS. A conducting path between the right auricle and the external wall of the right ventricle in the heart of the mammal. J Physiol. 1914;48:57.

    Google Scholar 

  18. Kent AFS. Observations on the auriculo-ventricular junction of the mammalian heart. Q J Exp Physiol. 1913;7:193–5.

    Google Scholar 

  19. Kent AFS. The structure of the cardiac tissues at the auriculo ventricular junction. J Physiol. 1913;47:17–8.

    Google Scholar 

  20. Kent AFS. The right lateral auriculo-ventricular junction of the heart. J Physiol. 1914;48:22–4.

    Google Scholar 

  21. Kent AFS. Illustrations of the right lateral auriculo-ventricular junction in the heart. J Physiol. 1914;48:63–4.

    Google Scholar 

  22. Truex RC, Bishof JK, Hoffman EL. Accessory atrioventricular muscle. Bundles of developing human heart. Anat Rec. 1958;131:45.

    CAS  PubMed  Google Scholar 

  23. James TN. Morphology of the human atrioventricular node with remarks pertinent to its electrophysiology. Am Heart J. 1961;62:756.

    CAS  PubMed  Google Scholar 

  24. Holzmann M, Scherf D. Uber elektrokardiogramme mit verkurzter Vorhof-Kammer Distanz und positiven P. Zacken Z Klin Med. 1932;121:404–10.

    Google Scholar 

  25. Wood FC, Wolferth CC, Geckeler GD. Histologic demonstration of accessory muscular connections between auricle and ventricle in a case of short P-R interval and prolonged QRS complex. Am Heart J. 1943;25:454–62.

    Google Scholar 

  26. Ohnell RF. Pre-excitation. A cardiac abnormality. Patho-physiological, patho-anatomical and clinical studies of an excitatory spread phenomenon. Acta Med Stand (Suppl CLIP). 1944;1:74–167.

    Google Scholar 

  27. Durrer D, Roos JP. Epicardial excitation of ventricles in patient with Wolff-Parkinson-White syndrome (type B). Circulation. 1967;35:15–21.

    CAS  PubMed  Google Scholar 

  28. Anton E. Becker, Robert H. Anderson, ; Dirk Durrer, and Hein J.J. Wellems. The anatomic substrates of Wolff-Parkinson-White syndrome A Clinicopathologic correlation in seven patients. Circulation 1978; 57: 870-879.

    CAS  PubMed  Google Scholar 

  29. Durrer D, Schoo L, Schuilenburg RM, Wellens HJ. The role of premature beats in the initiation and the termination of supraventricular tachycardia in the Wolff-Parkinson-White syndrome. Circulation. 1967;36:644–62.

    CAS  PubMed  Google Scholar 

  30. Wellens HJ, Schuilenburg RM, Durrer D. Electrical stimulation of the heart in patients with Wolff-Parkinson-White syndrome, type A. Circulation. 1971;43:99–114.

    CAS  PubMed  Google Scholar 

  31. Gollob MH, Tang A, Karibe A, et al. Identification of a gene responsible for familial Wolff–Parkinson–White syndrome. N Engl J Med. 2001;344:1823–31. http://www.nejm.org/doi/full/10.1056/nejm200106143442403#t=article.

    CAS  PubMed  Google Scholar 

  32. Mehdirad AA, Fatkin D, DiMarco JP. Electrophysiologic characteristics of accessory atrioventricular connections in an inherited form of Wolff-Parkinson-White syndrome. J Cardiovasc Electrophysiol. 1999;10:629–35.

    CAS  PubMed  Google Scholar 

  33. Chugh A, Morady F. Preexcitation, atrioventricular reentry, and variants. In: Zipes DP, editor. Cardiac electrophysiology: from cell to bedside. Philadelphia, PA 19103-2899: Elsevier Health Sciences; 2018.

    Google Scholar 

  34. Giardina ACV, Ehlers KH, Engle ME. Wolff-Parkinson-White syndrome in infants and children. A long-term follow-up study. Br Heart J. 1972;34:839–46.

    CAS  PubMed  PubMed Central  Google Scholar 

  35. Gallagher JJ, Oritchett ELC, Sealey WC, et al. The Preexcitation syndromes. Prog Cardiovasc Dis. 1978;20:285–327.

    CAS  PubMed  Google Scholar 

  36. Ruskin JN, Akhtar M, Damato AN, et al. Abnormal Q waves in Wolff-Parkinson-White syndrome. Incidence and clinical significance. JAMA. 1976;235:2727–30.

    CAS  PubMed  Google Scholar 

  37. Gallagher JJ, Gilbert M, Svenson RH, et al. Wolff-Parkinson-White syndrome: the problem, evaluation and surgical correction. Circulation. 1975;51:767–85.

    CAS  PubMed  Google Scholar 

  38. Campbell RWF, Smith RA, Gallagher JJ, et al. Atrial fibrillation in the preexcitation syndrome. Am J Cardiol. 1977;40:514–20.

    CAS  PubMed  Google Scholar 

  39. Spurrell RA, Krikler D, Sowton E. Two or more intra AV nodal pathways in association with either a James or Kent extranodal bypass in 3 patients with paroxysmal supraventricular tachycardia. Br Heart J. I973;35:113–22.

    Google Scholar 

  40. Zipes DP, Drjoseph RL, Rothbaum DS. Unusual properties of accessory pathways. Circulation. 1974;49:1200–11.

    CAS  PubMed  Google Scholar 

  41. Coumel P, Attuel P. Reciprocating tachycardia in overt and latent pre-excitation: influence of functional bundle branch block on the rate of the tachycardia. Eur J Cardiol. 1974;1:423–36.

    CAS  PubMed  Google Scholar 

  42. Mahaim I, Benatt A. Nouvelles recherches sur les connexions superieures de la branche gauche du faisceau de His-Tawara avec la cloison inter-ventriculaire. Cardiologia. 1937;1:61–73.

    Google Scholar 

  43. Brechenmacher C. Atrio-His bundle tracts. Br Heart J. 1975;37:853–5.

    CAS  PubMed  PubMed Central  Google Scholar 

  44. Inoue K, Igarashi H, Fukushige J, et al. Long-term prospective study on the natural history of Wolff-Parkinson-White syndrome detected during a heart screening program at school. Acta Paediatr. 2007:89. https://doi.org/10.1111/j.1651-2227.2000.tb00334.x.

  45. Jared Bunch T, May HT, Bair TL. Long-term natural history of adult Wolff–Parkinson–White syndrome patients treated with and without Catheter Ablation. Circ Arrhythm Electrophysiol. 2015;8:1465–71.

    PubMed  Google Scholar 

  46. Pappone C, Vicedomini G, Manguso F, et al. The natural history of WPW syndrome. Eur Heart J Suppl. 2015;17(Supplement A):A8–A11.

    Google Scholar 

  47. Pappone C, Santinelli V, Rosanio S, et al. Usefulness of invasive electrophysiologic testing to stratify the risk of arrhythmic events in asymptomatic patients with Wolff-Parkinson-White pattern: results from a large prospective long-term follow-up study. J Am Coll Cardiol. 2003;41:239–44.

    PubMed  Google Scholar 

  48. Pappone C, Santinelli V, Manguso F, et al. A randomized study of prophylactic catheter ablation in asymptomatic patients with the Wolff-Parkinson-White syndrome. N Engl J Med. 2003;349:1803–11.

    CAS  PubMed  Google Scholar 

  49. Pappone C, Manguso F, Santinelli R, Vicedomini G, Sala S, Paglino G, Mazzone P, Lang CC, Gulletta S, Augello G, Santinelli O, Santinelli V. Radiofrequency ablation in children with asymptomatic Wolff-Parkinson-White syndrome. N Engl J Med. 2004;351:1197–205.

    CAS  PubMed  Google Scholar 

  50. Blomström-Lundqvist C, Scheinman MM, Aliot EM, et al. ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias∗—executive summary. A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee for practice guidelines (writing committee to develop guidelines for the management of patients with Supraventricular Arrhythmias) developed in collaboration with NASPE-Heart Rhythm Society. J Am Coll Cardiol. 2003;42(8):1494–531.

    Google Scholar 

  51. Klein GJ, Yee R, Sharma AD. Longitudinal electrophysiologic assessment of asymptomatic patients with the Wolff–Parkinson–White electrocardiographs pattern. N Engl J Med. 1989;320:1229–33.

    CAS  PubMed  Google Scholar 

  52. Obeyesekere MN, Leong-Sit P, Massel D, et al. Risk of arrhythmia and sudden death in patients with asymptomatic preexcitation A meta-analysis. Circulation. 2012;125:2308–15.

    PubMed  Google Scholar 

  53. Katritsis DG, Wellens HJ, Josephson ME. Mahaim Accessory Pathways. Arrhythm Electrophysiol Rev. 2017;6(1):29–32.

    PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Icahn School of Medicine, Mount Sinai Hospital, New York, NY, USA

    J. Anthony Gomes

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Gomes, J.A. (2020). Wolff–Parkinson–White Syndrome. In: Heart Rhythm Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-45066-3_7

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  • DOI: https://doi.org/10.1007/978-3-030-45066-3_7

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