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Novel Probes and Carriers to Target Senescent Cells

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Senolytics in Disease, Ageing and Longevity

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 11))

Abstract

Detecting senescent cells has become a task of increasing importance in recent years. The implication of cellular senescence in a variety of physiological processes as well as in various diseases is the main reason why potential diagnostic tools for senescent cells are sought. This chapter clearly and concisely addresses the discussion of the published tools (molecular based probes and nanocarriers) to carry out the diagnosis of senescent cells both in vitro and in vivo and in tissues. The comprehensive reading of this chapter will allow the reader to overview the advances in the area of the detection of cellular senescence using probes and carriers as diagnostic methods.

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Acknowledgements

B.L.-T. is grateful to the Spanish Ministry of Economy for her Ph.D. grant (FPU15/02707). J. F.-B. thanks to their postdoctoral fellowship (PAID-10-17). The authors are grateful to the Spanish Government (project RTI2018-100910-B-C41 (MCUI/AEI/FEDER, UE) and the Generalitat Valencia (Project PROMETEO/2018/024) for support.

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Authors and Affiliations

  1. Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Camino de Vera s/n, 46022, Valencia, Spain

    Beatriz Lozano-Torres, Juan F. Blandez, Félix Sancenón & Ramón Martínez-Máñez

  2. Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, 46022, València, Spain

    Beatriz Lozano-Torres, Juan F. Blandez, Félix Sancenón & Ramón Martínez-Máñez

  3. CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain

    Beatriz Lozano-Torres, Félix Sancenón & Ramón Martínez-Máñez

  4. Unidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina, Universitat Politècnica de València, Centro de Investigación Príncipe Felipe, Valencia, Spain

    Beatriz Lozano-Torres, Juan F. Blandez, Félix Sancenón & Ramón Martínez-Máñez

  5. Unidad Mixta de Investigación en Nanomedicina y Sensores, Universitat Politècnica de València, IIS La Fe, Valencia, Spain

    Beatriz Lozano-Torres, Juan F. Blandez, Félix Sancenón & Ramón Martínez-Máñez

Authors
  1. Beatriz Lozano-Torres
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  2. Juan F. Blandez
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  3. Félix Sancenón
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  4. Ramón Martínez-Máñez
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Corresponding author

Correspondence to Ramón Martínez-Máñez .

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Editors and Affiliations

  1. CRUK Cambridge Centre Early Detection Programme, Department of Oncology, Hutchison/MRC Research Centre, University of Cambridge, Cambridge, UK

    Daniel Muñoz-Espin

  2. European Research Institute for the Biology of Aging (ERIBA), University Medical Center Groningen, Groningen, The Netherlands

    Marco Demaria

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Lozano-Torres, B., Blandez, J.F., Sancenón, F., Martínez-Máñez, R. (2020). Novel Probes and Carriers to Target Senescent Cells. In: Muñoz-Espin, D., Demaria, M. (eds) Senolytics in Disease, Ageing and Longevity. Healthy Ageing and Longevity, vol 11. Springer, Cham. https://doi.org/10.1007/978-3-030-44903-2_9

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