Abstract
In humans in addition to diarrheal disease and sub-clinical infections the Cryptosporidium parasite can cause developmental delays and growth failure in malnourished infants. We hypothesized that genetic variants may be responsible for the differences in pathogen phenotypes. Resequencing thirty-two Bangladesh C. hominis isolates identified both polymorphic regions and evidence of frequent genetic recombination. This increased the genetic diversity of the parasites. Additional studies are now needed to identify the genetic changes predisposing the parasite to the different phenotypes.
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Acknowledgements
We are grateful for the willing participation of the parents and children at the icddr,b study sites and wish to thank the field workers, nurses, laboratory staff of the Parasitology Laboratory of icddr,b without whom we could not have completed this research.
Conflict of Interest Statement
The author has no conflict of interest to disclose.
Funding
The work mentioned in this chapter was supported by the National Institute of Allergy and Infectious Diseases (NIAID) R21 AI142656 and R01 AI-043596, the Bill and Melinda Gates Foundation Grant (OPP1100514). Sequencing was at the Wellcome Trust Sanger Institute which is supported by the Wellcome Trust. Work at icddr,b is supported by the core donors (Government of the People’s Republic of Bangladesh, GAC, Sida, UKAid). The funders had no participation in the writing of this chapter or the decision to publish.
Ethical Considerations
The work reported here as reviewed by the Ethical and Research Review Committees of the International Centre for Diarrhoeal Disease Research, Bangladesh and by the Institutional Review Board of the University of Virginia. Informed written consent was obtained from the parents or guardians for the participation of their child in the study.
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Gilchrist, C.A. (2020). Cryptosporidium Infection in Bangladesh Children. In: Guillen, N. (eds) Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-44826-4_7
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