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International Conference on Computational Bioengineering

ICCB 2019: Computational Bioengineering and Bioinformatics pp 12–21Cite as

Heart Mechanical Model Based on Holzapfel Experiments

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Part of the book series: Learning and Analytics in Intelligent Systems ((LAIS,volume 11))

Abstract

We have formulated orthotropic material model for human heart tissue based on experimental investigation of passive material properties of myocardium [1]. The Cauchy stress/stretch and shear stress/amount of shear relation curves are used, which are established experimentally under different loading conditions: biaxial extension and triaxial shear. The averaged curves obtained from all considered specimens in [1] are reconstructed and used in our FE computational model. A computational procedure for determination of stresses for current stretches and amounts of shear at integration points of the FE model is implemented in the code PAK. Compressibility condition is imposed to couple the normal stresses using a penalty formulation. Applicability and reliability of this material model is tested on simple 3D models and on a heart wall segment under passive conditions. This numerical model offers an accurate description of the ventricular mechanics and can be used in studying heart problems in order to improve medical treatment of heart diseases.

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References

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Acknowledgments

The authors acknowledge support from the City of Kragujevac, Serbia.

Funding

This work is supported by the SILICOFCM project that has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 777204. This research was also funded by Ministry of Education and Science of Serbia, grants OI 174028 and III 41007.

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Authors and Affiliations

  1. The Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Avenue, R7 117, Houston, TX, 77030, USA

    Milos Kojic

  2. Bioengineering Research and Development Center BioIRC Kragujevac, Prvoslava Stojanovica 6, 34000, Kragujevac, Serbia

    Milos Kojic, Miljan Milosevic, Bogdan Milicevic & Vladimir Simic

  3. Serbian Academy of Sciences and Arts, Knez Mihailova 35, 11000, Belgrade, Serbia

    Milos Kojic

  4. Belgrade Metropolitan University, Tadeusa Koscuska 63, 11000, Belgrade, Serbia

    Miljan Milosevic

  5. Faculty for Engineering Sciences, University of Kragujevac, Sestre Janic 6, 34000, Kragujevac, Serbia

    Bogdan Milicevic & Vladimir Simic

Authors
  1. Milos Kojic
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  2. Miljan Milosevic
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  3. Bogdan Milicevic
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  4. Vladimir Simic
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Corresponding author

Correspondence to Milos Kojic .

Editor information

Editors and Affiliations

  1. Faculty of Engineering, University of Kragujevac, Kragujevac, Serbia

    Nenad Filipovic

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Kojic, M., Milosevic, M., Milicevic, B., Simic, V. (2020). Heart Mechanical Model Based on Holzapfel Experiments. In: Filipovic, N. (eds) Computational Bioengineering and Bioinformatics. ICCB 2019. Learning and Analytics in Intelligent Systems, vol 11. Springer, Cham. https://doi.org/10.1007/978-3-030-43658-2_2

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  • DOI: https://doi.org/10.1007/978-3-030-43658-2_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-43657-5

  • Online ISBN: 978-3-030-43658-2

  • eBook Packages: EngineeringEngineering (R0)

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