Skip to main content
SpringerLink
Log in

Stem Cell Therapy in Orthopedics

  • Chapter
  • First Online:
Orthopedics of the Upper and Lower Limb

  • 860 Accesses

Abstract

Stem cells are at the forefront of the development of new therapies for the treatment of orthopedic conditions. The development of these therapies, and the move to the use of regenerative medicine and tissue engineering to address these conditions, may well lead to a substantial change in not only how these conditions are treated but when in the disease process. Stem cell effects are believed to be brought about by two main mechanisms of action, and treatments have been developed to try and exploit both of these. Robust results from research and clinical trials will facilitate the more widespread adoption of these treatments in the health-care sector.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

  1. 1.

    Sometimes referred to as mesenchymal stromal cells.

  2. 2.

    CD73/CD90/CD105 positive and CD11b/CD14/CD19/CD34/CD45/CD79α/HLA-DR negative.

References

  1. Steadman J, Rodkey W, Singleton S. Microfracture technique for full-thickness chondral defects: technique and clinical results. Oper Tech Orthop. 1997;7:300–4.

    Article  Google Scholar 

  2. Blitch EL, Ricotta PJ. Introduction to bone grafting. J Foot Ankle Surg. 1996;35:458–62.

    Article  CAS  Google Scholar 

  3. Prockop DJ. Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms. Mol Ther. 2009;17:939–46.

    Article  CAS  Google Scholar 

  4. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663–76.

    Article  CAS  Google Scholar 

  5. Dominici M, Blanc LK, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop DJ, Horwitz E. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8:315–7.

    Article  CAS  Google Scholar 

  6. Ankrum JA, Ong J, Karp JM. Mesenchymal stem cells: immune evasive, not immune privileged. Nat Biotechnol. 2014;32:252–60. https://doi.org/10.1038/nbt.2816.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Lee J, Kim B-S, Lee H, Im G-I. In vivo tracking of mesenchymal stem cells using fluorescent nanoparticles in an osteochondral repair model. Mol Ther. 2012;20:1434–42.

    Article  CAS  Google Scholar 

  8. Prockop DJ, Oh J. Medical therapies with adult stem/progenitor cells (MSCs): a backward journey from dramatic results in vivo to the cellular and molecular explanations. J Cell Biochem. 2012;113:1460–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Goyal D, Keyhani S, Lee E, Hui J. Evidence-based status of microfracture technique: a systematic review of level I and II studies. Arthroscopy. 2013;29:1579–88.

    Google Scholar 

  10. Riboh JC, Cvetanovich GL, Cole BJ, Yanke AB. Comparative efficacy of cartilage repair procedures in the knee: a network meta-analysis. Knee Surg Sports Traumatol Arthrosc. 2017;25:3786–99.

    Article  Google Scholar 

  11. Nawaz SZ, Bentley G, Briggs TW, Carrington RW, Skinner JA, Gallagher KR, Dhinsa BS. Autologous chondrocyte implantation in the knee: mid-term to long-term results. J Bone Joint Surg Inc. 2014;96:824–30.

    Article  Google Scholar 

  12. Murphy MJ, Fink DJ, Hunziker EB, Barry FP. Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum. 2003;48:3464–74.

    Article  Google Scholar 

  13. Barry F. MSC therapy for osteoarthritis: an unfinished story. J Orthop Res. 2019;37:1229–35.

    Article  Google Scholar 

  14. Pers Y-M, Rackwitz L, Ferreira R, et al. Adipose mesenchymal stromal cell-based therapy for severe osteoarthritis of the knee: a phase I dose-escalation trial. Stem Cells Transl Med. 2016;5:847–56.

    Article  Google Scholar 

  15. Goldberg AJ, Zaidi R, Brooking D, Kim L, Korda M, Masci L, Green R, O’Donnell P, Smith R. Autologous stem cells in achilles tendinopathy (ASCAT): protocol for a phase IIA, single-centre, proof-of-concept study. BMJ Open. 2018;8:e021600.

    PubMed  PubMed Central  Google Scholar 

  16. Usuelli F, Grassi M, Maccario C, Vigano’ M, Lanfranchi L, Montrasio U, de Girolamo L. Intratendinous adipose-derived stromal vascular fraction (SVF) injection provides a safe, efficacious treatment for Achilles tendinopathy: results of a randomized controlled clinical trial at a 6-month follow-up. Knee Surg Sports Traumatol Arthrosc. 2018;26:2000–10.

    Article  Google Scholar 

  17. Food and Drug Administration. Regulatory considerations for human cells, tissues, and cellular and tissue-based products: minimal manipulation and homologous use. 2017.

    Google Scholar 

  18. Nicotera G, Sferrazza G, Serafino A, Pierimarchi P. The iterative development of medicines through the european medicine agency’s adaptive pathway approach. Front Med. 2019;6:148.

    Article  Google Scholar 

  19. Miyaki S, Lotz MK. Extracellular vesicles in cartilage homeostasis and osteoarthritis. Curr Opin Rheumatol. 2018;30:129–35.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Trauma and Orthopaedics, University of Cambridge, Cambridge, UK

    Benjamin M. Davies & Wasim S. Khan MBBCh, MRCS, PhD, FRCS

Authors
  1. Benjamin M. Davies
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wasim S. Khan MBBCh, MRCS, PhD, FRCS
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Benjamin M. Davies .

Editor information

Editors and Affiliations

  1. London, UK

    K. Mohan Iyer

  2. Addenbrooke Hospital, Cambridge, UK

    Wasim S. Khan

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Davies, B.M., Khan, W.S. (2020). Stem Cell Therapy in Orthopedics. In: Iyer, K., Khan, W. (eds) Orthopedics of the Upper and Lower Limb. Springer, Cham. https://doi.org/10.1007/978-3-030-43286-7_32

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-43286-7_32

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-43285-0

  • Online ISBN: 978-3-030-43286-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation