Skip to main content

Host Responses to Gut Microbes

  • Chapter
  • First Online:
Why Gut Microbes Matter

Part of the book series: Fascinating Life Sciences ((FLS))

  • 1236 Accesses

Abstract

So far, we have tended to emphasise the benefits of symbiotic association between the host and its gut microbiota. On the other hand, we know only too well that micro-organisms and viruses pose a continual threat to the survival of multicellular life forms, and these micro-organisms include many that either inhabit, or pass through, our gut. A wide range of viruses, bacteria and fungi are pathogens that have the ability to infect particular host species, while many protozoal species are pathogenic or parasitic. This has imposed incredibly strong selection for systems and mechanisms that help the host animal to defend itself against attack from micro-organisms and viruses.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 99.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. McPherson AJ et al (2008) The immunogeography of IgA induction and function. Mucosal Immunol 1:11–22

    Article  Google Scholar 

  2. Corthesy B (2013) Role of secretory IgA and maintenance of homeostasis. Autoimmun Rev 12:661–665

    Article  CAS  Google Scholar 

  3. Imhann F et al (2018) Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease. Gut 67:108–119

    Article  CAS  Google Scholar 

  4. Olszak T et al (2012) Microbial exposure during early life has persistent effects on natural killer T cell function. Science 336:489–493

    Article  CAS  Google Scholar 

  5. Rautova S et al (2004) The hygiene hypothesis of atopic disease – an extended version. J Pediatr Gastroenterol Nutr 38:378–388

    Article  Google Scholar 

  6. Sidiq T et al (2016) Nod2: a critical regulator of ileal microbiota and Crohn’s disease. Front Immunol 7:367

    Article  Google Scholar 

  7. Cerdena-Tarraga AM et al (2005) Extensive DNA inversions in the B. fragilis genome control variable gene expression. Science 307:1463–1465

    Article  Google Scholar 

  8. Bonder MJ et al (2016) The effect of host genetics in the gut microbiota. Nat Genet 48:1407–1412

    Article  CAS  Google Scholar 

  9. Goodrich JK et al (2016) Genetic determinants of the gut microbiome in UK twins. Cell Host Microbe 19:231–243

    Article  Google Scholar 

  10. Turpin W et al (2016) Association of host genome with intestinal microbial composition in a large healthy cohort. Nat Genet 48:1413–1417

    Article  CAS  Google Scholar 

  11. Allison AC (1956) The sickle-cell and Haemaglobin C genes in some African populations. Ann Hum Genet 21:67–69

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Flint, H.J. (2020). Host Responses to Gut Microbes. In: Why Gut Microbes Matter. Fascinating Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-43246-1_10

Download citation

Publish with us

Policies and ethics