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New-Generation Silicon Photomultiplier-Based Clinical PET/CT and PET/MR Systems

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Advances in PET

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Abstract

Modern PET imaging systems are fused with structural imaging modalities such as CT or MRI in order to enable multi-parametric characterization of disease. This chapter covers important design concepts for the new-generation clinical time-of-flight (TOF) PET systems that employ silicon photomultiplier (SiPM) technology, which can be incorporated in both PET/CT and PET/MR systems. First, we discuss the effects of PET system design parameters such as sensitivity and noise-equivalent count rate on clinical considerations, as well as the impact of SiPM-based detectors in this realm. Second, we focus on describing the design and architecture of the SiPM-based detector module used in the Discovery MI PET/CT and SIGNA PET/MR systems. Finally, we present performance characterization data for the Discovery MI PET/CT system, compare its performance to other PET/CT as well as PET/MR systems, and demonstrate its clinical imaging capability side by side with that of a previous-generation clinical PET/CT system.

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Authors and Affiliations

  1. Electrical Engineering and Radiology at Stanford University, Stanford, CA, USA

    David F. C. Hsu

  2. Radiology/Physics/Electrical Engineering/Bioengineering at Stanford University, Stanford, CA, USA

    Craig S. Levin

Authors
  1. David F. C. Hsu
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  2. Craig S. Levin
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Corresponding author

Correspondence to Craig S. Levin .

Editor information

Editors and Affiliations

  1. Department of Radiology, The Ohio State University, Columbus, OH, USA

    Jun Zhang

  2. Department of Radiology, The Ohio State University, Columbus, OH, USA

    Michael V. Knopp

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Hsu, D.F.C., Levin, C.S. (2020). New-Generation Silicon Photomultiplier-Based Clinical PET/CT and PET/MR Systems. In: Zhang, J., Knopp, M. (eds) Advances in PET. Springer, Cham. https://doi.org/10.1007/978-3-030-43040-5_4

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  • DOI: https://doi.org/10.1007/978-3-030-43040-5_4

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-43039-9

  • Online ISBN: 978-3-030-43040-5

  • eBook Packages: MedicineMedicine (R0)

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