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Cellular Senescence in Aging Mucosal Tissues Is Accentuated by Periodontitis

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Abstract

Understanding the biologic mechanisms that cause declines in cellular, tissue, and organ functions is a strategy to enhance a healthy aging process. The biology of aging is impacted by both environmental and genetic factors that pre-dispose to variation in the rate of senescence across the population, with extensive variation in aging effects at the individual subject level. These findings are consistent with broader health data demonstrating that aging is accompanied by increased susceptibility to autoimmune, infectious, and inflammatory diseases, including periodontitis. The interdisciplinary implementation of investigations in geroscience addresses aging in the context of chronic age–related diseases and geriatric syndromes. A component aspect underlying these interrelationships is the evolving area of biologic aging to better describe and predict an individual rate of senescence based upon arrays of intrinsic and extrinsic variables that could more effectively model the kinetics of appearance and progression of age-related diseases. This has led to evolving strategies for the development of geroprotective and senolytic therapeutics to enhance healthy aging. This report provides data regarding cellular senescence patterns in gingival tissues with healthy aging and periodontitis. It also proposes that this chronic widespread disease may not simply reflect aging processes by also being a detrimental factor for “gerovulnerability” that should advance new insights into the importance of prevention/treatment of periodontitis with the overall composite of healthy aging strategies.

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Acknowledgments

We want to thank M.J. Steffen, J. Stevens, and Dr. S.S. Kirakodu for expert technical support in developing biologic marker data for these types of studies. We also thank Drs. L. Orraca, J. Martinez-Gonzalez, S. Kirakodu, A. Stromberg, M.J. Novak from the University of Puerto Rico, Caribbean Primate Research Center, and University of Kentucky for their support in the work with nonhuman primates and data analysis. This work was supported by USPHS grants RR020145, GM110788, and GM103538 from the National Institutes of Health and funding from the Center for Oral Health Research in the UK College of Dentistry, as well as the Office of Research Infrastructure Programs (ORIP) of the National Institutes of Health (NIH) through Grant Number 5P40OD012217 to the Caribbean Primate Research Center.

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Authors and Affiliations

  1. Department of Biomedical Sciences, School of Dental Medicine, University of Nevada, Las Vegas, NV, USA

    J. L. Ebersole

  2. Center for Oral Health Research, University of Kentucky, Lexington, KY, USA

    J. L. Ebersole & O. A. Gonzalez

  3. Division of Periodontology, College of Dentistry, University of Kentucky, Lexington, KY, USA

    O. A. Gonzalez

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  1. J. L. Ebersole
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  2. O. A. Gonzalez
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Correspondence to J. L. Ebersole .

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  1. School of Dental Medicine, Department of Periodontics, University of Pennsylvania, Philadelphia, PA, USA

    Sinem Esra Sahingur

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Ebersole, J.L., Gonzalez, O.A. (2020). Cellular Senescence in Aging Mucosal Tissues Is Accentuated by Periodontitis. In: Sahingur, S. (eds) Emerging Therapies in Periodontics. Springer, Cham. https://doi.org/10.1007/978-3-030-42990-4_8

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  • DOI: https://doi.org/10.1007/978-3-030-42990-4_8

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