Skip to main content

Crystalline Arthropathy

  • Chapter
  • First Online:
Clinical Foundations of Musculoskeletal Medicine

Abstract

The crystalline arthropathies are a group of disorders in which crystals form in joints or surrounding soft tissue causing inflammation. The most common crystalline diseases in clinical practice are gout and pseudogout (CPPD disease). Gout is characterized by deposition of monosodium urate crystals in the joint and often high serum uric acid levels. Pseudogout is characterized by calcium pyrophosphate dihydrate crystals and sometimes can be secondary to a metabolic condition. The acute management of these conditions relies on reducing inflammation although the long-term treatment strategies differ. If not treated early, these conditions can cause permanent joint damage and disability.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 89.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Chen-Xu M, Yokose C, Pillinger M, Choi HK. Contemporary prevalence of Gout and Hyperuricemia in the United States (National Health and Nutrition Examination Survey [NHANES] 2015-2016) and decadal trends (NHANES 2007-2016) [abstract]. Arthritis Rheumatol. 2018;70(suppl 9):1256–7.

    Google Scholar 

  2. Mikuls TR, Farrar JT, Bilker WB, et al. Gout epidemiology: results from the UK general practice research database, 1990–1999. Ann Rheum Dis. 2005;64:267–72.

    Article  CAS  Google Scholar 

  3. Shiozawa A, Szabo SM, Bolzani A, Cheung A, Choi HK. Serum uric acid and the risk of incident and recurrent Gout: a systematic review. J Rheumatol. 2017;44(3):388–96.

    Article  CAS  Google Scholar 

  4. Bardin T, Richette P. Definition of hyperuricemia and gouty conditions. Curr Opin Rheumatol. 2014;26(2):186–91.

    Article  CAS  Google Scholar 

  5. Cleophas MC, Joosten LA, Stamp LK, et al. ABCG2 polymorphisms in gout: insights into disease susceptibility and treatment approaches. Pharmgenomics Pers Med. 2017;10:129–42.

    PubMed  PubMed Central  CAS  Google Scholar 

  6. Lachmann HJ, Quartier P, So A, Hawkins PN. The emerging role of interleukin-1β in autoinflammatory diseases. Arthritis Rheum. 2011;63:314–24. https://doi.org/10.1002/art.30105.

    Article  PubMed  CAS  Google Scholar 

  7. Hainer BL, Matheson E, Wilkes RT. Diagnosis, treatment, and prevention of Gout. Am Fam Physician. 2014;90(12):831–6.

    PubMed  Google Scholar 

  8. Raddatz DA, Mahowald ML, Bilka PJ. Acute polyarticular gout. Ann Rheum Dis. 1983;42(2):117.

    Article  CAS  Google Scholar 

  9. Neogi T, Jansen TLTA, Dalbeth N, et al. 2015 Gout classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis. 2015;74:1789–98.

    Article  CAS  Google Scholar 

  10. Ogdie A, Taylor WJ, Neogi T, et al. Performance of ultrasound in the diagnosis of gout in a multicenter study: comparison with monosodium urate monohydrate crystal analysis as the gold standard. Arthritis Rheumatol. 2017;69:429–38.

    Article  Google Scholar 

  11. Zhang Y, Chen C, Choi H, Chaisson C, Hunter D, Niu J, Neogi T. Purine-rich foods intake and recurrent gout attacks. Ann Rheum Dis. 2012;71(9):1448.

    Article  CAS  Google Scholar 

  12. Nielsen SM, et al. Weight loss for overweight and obese individuals with gout: a systematic review of longitudinal studies. Ann Rheum Dis. 2017;76(11):1870. Epub 2017 Sep 2

    Article  Google Scholar 

  13. Reyes AJ. Cardiovascular drugs and serum uric acid. Cardiovasc Drugs Ther. 2003;17(5–6):397.

    Article  CAS  Google Scholar 

  14. Vargas-Santos, et al. Management of gout and hyperuricemia in CKD. Am J Kidney Dis. 2017;70(3):422–39.

    Article  CAS  Google Scholar 

  15. Chattopadhyay I, Shetty HGM, Routledge PA, Jeffery J. Colchicine induced rhabdomyolysis. Postgrad Med J. 2001;77(905):191.

    Article  CAS  Google Scholar 

  16. Abhishek A. Epidemiology of calcium pyrophosphate crystal arthritis and basic calcium phosphate crystal arthropathy. Rheum Dis Clin N Am. 2014;40(2):177–91.

    Article  Google Scholar 

  17. Pang L, et al. Pseudogout-associated inflammatory calcium pyrophosphate Dihydrate microcrystals induce formation of neutrophil extracellular traps. J Immunol. 2013;190(12):6488–500.

    Article  CAS  Google Scholar 

  18. Nalbant S, et al. Synovial fluid features and their relations to osteoarthritis severity: new findings from sequential studies. Osteoarthr Cartil. 2003;11(1):50–4.

    Article  CAS  Google Scholar 

  19. Rosenthal AK, Ryan LM. Calcium pyrophosphate deposition disease. N Engl J Med. 2016;374(26):2575–84. http://dx.doi.org.libproxy.lib.unc.edu/10.1056/NEJMra1511117

    Article  CAS  Google Scholar 

  20. Rosales-Alexander JL, Balsalobre Aznar J, Magro-Checa C. Calcium pyrophosphate crystal deposition disease: diagnosis and treatment. Open Access Rheumatol. 2014;6:39–47. Published 2014 May 8. https://doi.org/10.2147/OARRR.S39039.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  21. Zhang W, Doherty M, Pascual E, et al. EULAR recommendations for calcium pyrophosphate deposition. Part II: management. Ann Rheum Dis. 2011;70:571–5.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rami ElTaraboulsi .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

ElTaraboulsi, R. (2021). Crystalline Arthropathy. In: Esther, R.J. (eds) Clinical Foundations of Musculoskeletal Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-42894-5_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-42894-5_12

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-42893-8

  • Online ISBN: 978-3-030-42894-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics