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Solid-State Pharmaceuticals: Solving Complex Problems in Preformulation and Formulation

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Pharmaco-complexity

Part of the book series: AAPS Introductions in the Pharmaceutical Sciences ((AAPSINSTR))

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Abstract

Pharmaceutical systems and products almost always include solid-state ingredients either during manufacture or as the dosage form itself. Thus preformulation and formulation of drug products is often critically dependent on the characterization and understanding of these physicochemical properties. Despite their seemingly simplicity, attributes like dissolution, particle shape, and powder flow can be exceedingly complex and often require nonlinear approaches for modeling, prediction, and analysis. This section provides examples both from static and dynamic processes encountered in pharmaceutical preformulation/formulation development.

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  1. RTI International, Research Triangle Park, NC, USA

    Anthony J. Hickey

  2. College of Pharmacy, The University of Texas at Austin, Austin, TX, USA

    Hugh D. C. Smyth

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Hickey, A.J., Smyth, H.D.C. (2020). Solid-State Pharmaceuticals: Solving Complex Problems in Preformulation and Formulation. In: Pharmaco-complexity. AAPS Introductions in the Pharmaceutical Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-42783-2_3

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